细胞坏死

In situ hybridization was used to localize IL-4, IL-6, IL-1β, IL-2, IFN-γ and TNF-α mRNAs in abomasum of the negative control group, challenged control group, vaccinated-challenged group and vaccinated-unchallenged group goats immunized with rHco-GAL-f/m, and the numbers of cytokine mRNA(superscript +) cells in each group were also analyzed.

用rHco-GAL-f/m免疫山羊，通过原位杂交法对阴性对照组、攻虫对照组、免疫攻虫组和免疫不攻虫组山羊皱胃中白介素－1β(IL-1β)、白介素－2(IL-2)、白介素－4(IL-4)、白介素－6(IL-6)、干扰素－γ和肿瘤坏死因子－αmRNA转录进行定位，并对上述细胞因子阳性反应细胞数量进行分析。

Results: There were 18 cases of astrocytomas, 2 cases of cavernous angioma, 1 cases of hemangioblastoma, 1 cases of dermoid cyst, 1 cases of syringopontia, 1 cases of inflammatory granuloma accompanied with hecrosis and 1 cases of AVM of brain stem in 25 cases.

结果 25例病人中，星形细胞瘤18例，海绵状血管瘤2例，血管母细胞瘤1例，表皮囊肿1例，桥脑空洞症1例，炎性肉芽肿组织伴坏死1例，脑干AVM 1例。

By immunohistochemistry, porcine parvovirus signals were mainly distributed in interstitial and necrotic lesions, and the positive signals could be found in macrophages-like cells and epithelial cells of terminal bronchiole and alveoli.

另外，以免疫组织化学染色检测猪小病毒，其阳性讯号主要分布於间质及坏死病灶区，此阳性讯号存於巨噬细胞与肺泡及终末细支气管上皮细胞。

Results By using optical microscope,the neurocytes of hippocampus in experimental group were observed to denaturalize,tumefy,destroy and disappear.And under electron microscope,the karyon was irregular,nucleoles deviated,chondriosome tumefied,crista collapsed,membrane was damaged,substance cavitated.Such changes were more evident with the increased paroxysm of epilepsy,the parameters between control group and operation group had no difference（P＞0.01）.But make a monofactorial variance analysis among cells' number,area,circumference and integral optical density in different groups,it showed that there were significant differences between optional two groups（P.01;at the same time,the more serious injury in hippocampus,the more powerful GFAP immunoreaction was.

结果： 实验组海马区光镜下可见神经细胞变性、肿胀、坏死及神经细胞脱失改变，电镜可见细胞核形态不规则、有切迹、核仁偏位、线粒体肿大、嵴断裂、膜破损和基质空化等改变，随癫痫发作次数增加上述改变越明显，对照组与手术对照组比较，各参数差异无显著性（P＞0.05），将不同组别大鼠细胞数、面积、周长、积分光密度分别作单因素方差分析，不同组别间均差异有显著性（P.01），同时观察到海马区GFAP免疫反应阳性的胶质细胞随海马损伤的加重而GFAP免疫反应增强。

Positive comedo necrosis was related with c-erbB-2,cathepsin D in tumor epithelial cell and proliferation indexP value was 0.042,0.006 and 0.013 respectively）.

粉刺状坏死的出现，与c-erbB-2癌基因、肿瘤上皮细胞中的组织蛋白酶D和细胞增殖指数相关（P分别为0.042，0.006及0.013）。

No DNA fragments were observed in electrophoresis in scrotal testis and cryptorchid testis on 3d.

而混合培养的生精细胞，在30min、1h可见明显的DNA ladder小片断，2h及12h则主要以坏死细胞造成的弥散小片断DNA为主。

The border of hyperplastic nodal which had no pathological nuclear mitoses, invasion and necrosis was clear. The staining of 8 antidodies had not significant value to the differential diagnosis between basal cell adenocarcinoma and adenoma of prostate.

而基底细胞腺瘤内增生的基底细胞异型性不明显，无病理性核分裂象，增生结节周界清，无浸润性边缘和坏死。8种抗体的免疫酶标记在前列腺基底细胞腺癌和腺瘤的鉴别诊断上无显著性意义。

It is also believed that tumor cells present in blood and/or lymph were necrotized by the activated cellular immune-competent cells.

这是因为细胞内的免疫细胞的激活导致了血液或淋巴液中的肿瘤细胞的坏死。

Observations underelectron microscopy showed that YSV destroyed the structure of chromatin,damaged cell organelles of tumor cells, and induced apoptosis and necrosis intumor cells.

超微结构研究显示，YSV(320μg／kg／d)诱导人肝癌BEL-7402细胞的染色质溶解、固缩，细胞器的普遍崩解，细胞出现凋亡和坏死。

TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem,2003, 278(32):30317-30327.3 Hamada H,Suzuki M,Yuasa S,et al.

使用2μg/mL和5μg/mL的TM诱导M诱导48h后，乳鼠心肌细胞均出现明显的弥散状改变，说明此时细胞发生了坏死，而细胞凋亡应该是发生在48h 以内。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。