细胞坏死

Results HE staining showed that sulindac could inhibit the growth of tumor cells, with the morphological presentations as apoptosis and necrosis including pyknosis, karyorrhexis and chromatin crescent formation, etc. By electron microscopy, cells also had apoptotic characteristics including chromatin crescent formation and apoptotic body. Immunohistochemistry and Western-blot assay results showed that 48 hours after sulindac administration, the expression of NF-κB, bcl-2 and bax gradually decreased, while the level of bax protein gradually increased, in a dose dependence manner.

结果 苏木精－伊红染色检测结果显示舒林酸抑制肿瘤细胞生长，肿瘤细胞出现核固缩、核碎裂、染色质边集等凋亡及坏死的形态学表现；电镜下可看到染色质边集、凋亡小体；免疫组化、Western-blot结果显示舒林酸作用48 h后人胃癌SGC-7901细胞NF-κB、bcl-2表达逐渐下降，bax表达逐渐上升，具有剂量依赖性。

Rhizoma sparganii and radices zedoariae can protect hepatic cells, alleviate degeneration and necrosis, recover structure and function, and reduce the proliferation of fibrous tissue.

三棱、莪术有保护肝细胞、减轻肝细胞变性坏死，恢复肝细胞结构和功能；减少纤维组织增生、阻止纤维化发展，促进纤维组织降解的作用。

Results The supratentorial lesions involved the occipital lobe in 4, frontal lobe in 3, fronto-occipital lobe in 2, temporo-occipital lobe in 3, lateral ventricle in 1 case and the saddle region in 1. All the lesions were large in volume and most of them presented heterogeneous signals in MRI. Of the 14 cases, 12 showed cystic degeneration and necrosis, 2 had hemorrhage and 6 showed signs of emptied small blood vessels. Twelve cases had heterogeneous enhancement and 2 had moderate enhancement. Pathologically, 10 cases of neuroblastomas were identified, along with 3 ganglioneuroblastomas and 1 atypical rhabdoid tumor.

结果 病灶位于顶叶4例，额叶3例，枕顶叶2例，颞枕叶3例，侧脑室1例，鞍区1例，病灶普遍较大，病灶绝大多数信号不均匀，病灶内可见囊变／坏死（12例）、出血（2例）、流空小血管影（6例），增强后病灶呈明显不均匀强化（12例），中等强化2例；神经母细胞瘤10例，节细胞神经母细胞瘤3例，非典型横纹肌样瘤1例。

Supervital NBS staining Nile Blue Sulphate , a lysosomotropic vital dye which stains embryonic apoptotic, but not necrotic cell death, is employed to identify the occurence and location of apoptosis.

活体胚胎的NBS染色 NBS是一种亲溶酶体染料，可使凋亡细胞着色，而坏死细胞不着色，因而可初步判定细胞凋亡发生的区域和程度。

The activation of endothelial cell caused by TNF-α has detrimental effects on the vasculature. TNF-α can induce the increased apoptosis of gravid trophocyte. TNF-α has been showing up-regulate the vasoconstriction factors such as endothelin and down-regulate the vascular relaxing factors such as NO on the contrary.

肿瘤坏死因子α作为炎性分子，激活血管内皮细胞、间接影响血管舒缩功能，通过各种机制诱导胎盘滋养细胞凋亡增加，增加血管收缩因子并减少血管舒张因子的生成和释放，影响与脂类代谢相关的细胞因子。

Cytokines found to have up-regulated in cells were measured in serum and lung tissue of rats exposed to large tidal volume ventilation. For investigating the intracellular pathway of cytokine up-regulation in VILI, exogenous TNF-α or H2O2 was added to culture media of alveolar epithelial cells. Cytokines were then measured. To explore the role of oxidant stress in VILI, N-acetylcysteine, as an anti-oxidant, was used in vitro and in vivo.

我们在体外培养的肺上皮细胞中加入外源性肿瘤坏死因子、过氧化氢或N-乙酰半胱氨酸，观察细胞因子的变化。N-乙酰半胱氨酸亦被投入大鼠呼吸机诱导肺损伤模型，观察用药后细胞因子的变化。

In the in vivo experiment, it was observed that, in the peritoneum from the XYNR treated mice inoculated with S180, the mesothelial cells arranged more and more regularly with the increasing of the dosage of XYNR, while the mesothelial cells in the peritoneum of the mice in the control group necrosed and arranged loosely.

用悬饮宁治疗S180腹水瘤小鼠后，取出腹膜，在电镜下可观察到，从低剂量开始即可见小鼠腹膜间皮细胞排列整齐，随着剂量的递增这种现象更明显，间皮细胞排列更加整齐，增厚；而生理盐水组小鼠腹膜间皮细胞排列疏松，坏死。

In the in vivo experiment, it was observed that, in the peritoneum from the XYNRtreated mice inoculated with S180, the mesothelial cells arranged more and more regularly with the increasing of the dosage of XYNR, while the mesothelial cells in the peritoneum of the mice in the control group necrosed and arranged loosely.

用悬饮宁治疗S180腹水瘤小鼠后，取出腹膜，在电镜下可观察到，从低剂量开始即可见小鼠腹膜间皮细胞排列整齐，随着剂量的递增这种现象更明显，间皮细胞排列更加整齐，增厚；而生理盐水组小鼠腹膜间皮细胞排列疏松，坏死。

Pathologic examination included: tubulointerstitial lesion which was the main pathologic presentation, tubular epithelial cell becoming flat, TEC necrosis and wither, departure between the cytoplasm and basis membrane, drops of protein in cytoplasm, broken basic membrane of TEC, inflammatory cells infiltrating in tubulointerstitium, tubulointerstitium fibrosis, plasm cell infiltration.

MM肾损害主要以小管-间质病变为主，病理表现为肾小管上皮细胞扁平，存在不同程度变性、坏死或萎缩，胞浆与基膜分离，胞浆内可见蛋白滴，甚至小管基膜断裂，间质炎性细胞浸润、纤维化，部分有淀粉样物质沉积，较少见浆细胞浸润。

Results: The animal experimental model indicates the facial nerve' s bone canal fracture can make the facial nerve hyperaemia, strut, and putrescence, denaturalization and with the Schwann cell and the cell become more and more, taking on the restore evidence.

结果 动物实验表明：面神经骨管骨折后，面神经发生充血肿胀，并出现脱髓鞘、变性及坏死的变化，伴随神经损伤的同时出现巨噬细胞和施万细胞增生肥大及纤维母细胞的增生，呈现修复迹象。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。