细胞坏死

Results 2 ClAdo and 2 CldAdo had different cytotoxicities on the cells, while 2' dAdo had no cytotoxicity on the cells. 2 CldAdo blocked the cell growth at the phase of S and G2/M, while 2 ClAdo at the phase of G0/G1. 2 CldAdo mainly induced cell necrosis, while 2 ClAdo induced both cell necrosis and apoptosis. Down regulated Bcl 2 expression and up regulated p53 and Bax expression were associated with 2 ClAdo, while 2 CldAdo down regulated Bcl 2 expression and up regulated mildly p53 expression without any effect on Bax expression.

结果 2 ClAdo、2 CldAdo对所研究的细胞均有程度不等的毒性；2' dAdo对各细胞生长、增殖均无明显抑制（c=100 μmol/L即30 μg/mL内）；2 CldAdo明显阻断细胞于S、G2/M期，2 ClAdo阻断细胞于G0/G1期；2 CldAdo 致细胞坏死为主，2 ClAdo 既致细胞坏死又诱导凋亡；2 ClAdo 下调Bcl 2，上调P53、Bax蛋白表达；2 CldAdo小幅上调P53、小幅下调Bcl 2，不影响Bax蛋白表达。

Necrosis and apoptosis that gradually increase and eventually result in enervation and death of chicken with selenium-penia. The effect of selenium on the lipid peroxidation of the cellular membrane system of tissues is the main mechanism that selenium induces apoptosis of tissues.

雏鸡硒缺乏时，甲状腺、肝脏、胸部肌肉、胰腺、胸腺等组织细胞凋亡增加，证明硒缺乏雏鸡体内发生两种细胞死亡，即坏死和细胞凋亡，由于细胞坏死和凋亡的加重与增多，致使硒缺乏雏鸡走向衰竭，最后死亡。

The pathologic changes were observed by light and electron microscope.Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性，并可见肝细胞坏死灶，姜黄素治疗组的肝细胞未见坏死改变，水样变性和脂肪变性程度减轻，以高剂量姜黄素组的治疗效果最为明显。

Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.Hepatocytes in curcumine treatment group showed no necrotic changes,and the degree of hydropic and fatty degeneration was markedly reduced,especially in the high-dose curcumine treatment group.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性，并可见肝细胞坏死灶，姜黄素治疗组的肝细胞未见坏死改变，水样变性和脂肪变性程度减轻，以高剂量姜黄素组的治疗效果最为明显。

The principal microscopic lesions were the inflammation,and necrosis of the mucoase membranes of proventriculus,degeneration of the parenchymatous cells o...

主要的组织学变化为腺胃粘膜上皮坏死脱落、固有层水肿、有炎性细胞浸润、肌层有淋巴细胞浸润、肌细胞坏死、腺小叶腺细胞坏死、核浓缩。

In the second group of which pancreas allogenic graft was made combining with duodenum: schistic necrosis of pancreatic gland alveolus at 3 d post operation, necrosis of pancreatic folia and pancreatic islet at 5 d post operation, widespread necrosis and disappear of structure at 7 d post operation were observed.

胰、十二指肠移植组：术后3 d胰腺腺泡细胞片状坏死；术后5 d胰腺小叶和部分胰岛细胞坏死；术后7 d腺泡细胞大片坏死，胰岛结构消失。

The first, many tuberculosises in glandular stomach were found besides liver cell degeneration, pneumoncongestion, epithelium cell degeneration of tubuli tenales, necrosis and kidney hemorrhage, cardiac muscle celldegeneration, heart hemorrhage, cerebrum hemorrhage, satellitosis and neuronophagia, cerebellum purkinje cell necrosis.

发现病例1，肝细胞变性，肺淤血，肾小管上皮细胞变性、坏死，间质出血，心肌纤维变性，间质出血，大脑出血，&卫星化&与&噬神经&现象，小脑浦肯野氏细胞坏死，还可见腺胃有大量的结核结节。

Results: There were normal appearances of the morphology, volume and microscopic demonstration of both right and left hepatic lobes in sham-operating control group. In HA+PV group, hepatic right lobes were coagulatively necrosed. There was necrosis of liver cells in each sub-groups, accompanying with a few apoptic cells in the 3h sub-group. Along with the time extending, necrotic cells were increasing, and apoptic cells were decreasing. Necrosis in right lobes was at the most at 72h group.

结果：假手术对照组肝左右叶形态、体积以及各种病理学检查均未见异常；HA+PV组术后肝右叶发生凝固性坏死，3h即可见点片状肝细胞坏死，内见少量凋亡细胞，随时间延长，凋亡细胞减少，坏死细胞增多，至72h坏死更加彻底：PV组术后24h肝右叶萎缩，电镜及TUNEL均显示3h组织内可见凋亡细胞，至24h凋亡细胞数达高峰，72h凋亡细胞减少，出现局灶性坏死。

PartⅡExperimental Study on Acute Hypatocyte Necrosis and Apoptosis with MRI, DWI and MRS Objective: To demonstrate the ability and value of MR imaging, diffusion-weighted imaging, and MR spectroscopy in detecting and characterizing necrosis and apoptosis in vivo with a comparison to the pathology after establishment of hepatic necrosis and apoptosis animal model by different surgical ligations of hepatic blood supply vessels.

目的：通过手术结扎的方法建立大鼠肝细胞坏死和凋亡的动物模型，将不同时间点的MRI、DWI和MRS检测结果与病理学所见进行对照研究，以评价MRI、DWI及MRS在检测及鉴别肝细胞凋亡和坏死两种病理改变的能力与价值。

Histologically, the seminiferous tubules contained numerous Sertoli cells and more Sertoli-spermatozoa complexes, accompanied by the depletion of Leydig cells with deeply stained nuclei. Mature spermatozoa were stored up in the epididymis, but only a few in the efferent ducts. In the second place was testicular atrophy（32/120; 26.7%）. The seminiferous tubules showed moderate to severe inactivity of spermiogenesis with evidence of only spermatogonia, spermatocytes and Sertoli cells. The Leydig cells were obviously decreased in numbers associated with decrease of lipid droplets in their cytoplasms. Testicular hypoplasia was the third disorders（22/120; 18.3%）. Only a few spermatogonia and Sertoli cells appeared without any spermiogenesis. The associated changes was decreased in Leydig cells and fibrous hyperplasia in the interstitium.Epididymal stones were sometimes found（12/120; 10%）. Grossly, yellowish-white nodules with various sizes and firm in consistency were observed in the epididymis and the front efferent ducts. Microscopically, the epididymal ducts were dilated with voluminous spermatozoa storage, even showed calcification in severe cases. The deposited calcium salts were stained positively by Von Kossa and Alizarin red methods.Amyloidosis was also detected in 10 roosters（8.3%）. Eosinophilic, homogeneous, amyloid-like substances were deposited mainly in the testicular interstitium and the periphery of blood vessels. These substances showed positive reaction by Congo red staining. Five roosters（4.2%）had Marek's lesions in the testis, epididymis and peripheral nerves with infiltration of pleomorphic lymphocytes. Only one case showed epithelial necrosis of seminiferous tubules accompanied by fibrous proliferation in the interstitium.

结果发现，在总共搜集的120个病例中，其中因年老所导致的产精力不佳为最多，占38例（31.7%），於镜下可见大量精虫黏附於Sertoli cell的表面，并可见Sertoli cell数量明显增多而Leydig cell明显减少，且其细胞核呈现浓染的现象，而在其副睪中仍可见到成熟精虫蓄留於管腔中，但在其输精管内却只有少量精虫存在；其次为睪丸萎缩，占32例（26.7%），镜下可见中度至重度无造精作用，其生精小管中只见到精母细胞、精原细胞及Sertoli cell存在，但Leydig cell数量明显减少且其细胞质内的脂质也明显减少；睪丸发育不全，占22例（18.3%），於生精小管内只见到精母细胞及少量Sertoli cell存在，不见造精细胞分化，於生精小管间质可见Leydig cell减少并伴随结缔组织增生；副睪结石，占12例（10%），肉眼下可在副睪及输精管前段见到黄白色大小不一的结节，触感坚硬，於镜下可见副睪管扩张并有大量成熟精虫蓄积，严重时可见钙化现象，以Von Kossa及茜素红染色均呈阳性反应；类淀粉沉著症，占10例（8.3%），镜下在睪丸间质及血管周围可见粉红均质样的物质沉积，以刚果红染色成阳性反应；马立克病，占5例（4.2%），镜下可在睪丸、副睪实质及周边神经内均可见到嗜碱性大小不一的淋巴样细胞浸润；睪丸坏死，占1例（0.8%），镜下可见生精小管上皮细胞坏死脱落及间质结缔组织增生。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。