细胞发生的

CaLP's phosphorylation state analysis of different localization showed that when CaLP is overexpressed alone, it is in state of phosphorylation and stays in the cytoplasm; when CaLP is co-transfected with p21, p21 overexpression causes its unphosphorylation and translocated from cytoplasm to nucleus.

对定位于不同部位的CaLP的磷酸化状态的分析表明：当在细胞中单独表达CaLP时，它以磷酸化形式存在，且磷酸化的位点发生在Y139上，CaLP因此定位于细胞质中；当共表达CaLP与p21时，p21的过表达引起CaLP发生去磷酸化，CaLP由细胞质穿梭入细胞核并与p21发生直接相互作用。

Giant cell tumor of bone is a kind of common bone tumor,which has characteristics of high recurrence rate and invasion.recently,tumor vessel angiogenesis has been the warm spot of research.genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.the correlated research has very important significance for judging gct prognosis and guiding therapy.

骨巨细胞瘤（giant cell tumor of bone，gct）是一种常见骨肿瘤，由于其高复发率和强侵袭性，备受临床骨科工作者的关注。骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。骨巨细胞瘤生物大分子研究的不断深化对判断gct的预后及指导治疗有重要意义。

Each medicine used in the study totally has obivious effect on lens sodium-pump. Either on the molecular and cellular level or on the histological and organic level , they all have their distinctive demonstration. 1.Ouabain、Digoxine、DMSO decrease the expression of αsubunit of sodium pump on mRNA level , the cell morphology and ultramicroscopic structure demonstrated destructive effect,it indicates the cause of cataract of the medicines.2.D-thyroxine、Amphotericin B、Vitamin E increase the expression of αsubunit of sodium pump on mRNA level ,from the demonstration of the cell morphology and ultramicroscopic structure ,it indicates the medicines have protective or anti-distructive effect on lens.3.The medicines have isoform-specific action on lens sodium-pump,it indicates exploitting isoform-specific medicine has a promising clinical application.4. Lens sodium-pumps are inhibited probably lead to cataract, so in clinical medication, especially to the cardiovascular doctor, while he is using the sodium-pump inhibitors, he should pay more attention to adjust the dosage and duration of the drug therapy. 5. To creat the animal model of cataract through inhibiting lens sodium-pump, whether it can be a kind of classical method or not, it is worthy of further research.

本研究所选用的药物对晶状体钠泵均有明显的影响作用，在分子水平、细胞水平、组织器官水平均有特异的表现：1、哇巴因、地高辛、二甲基亚砜三种药物可降低晶状体钠泵α亚单位在 mRNA水平的表达，在细胞形态和超微结构上表现为损伤效应，提示了其潜在的导致白内障的可能。2、D甲状腺素、两性霉素B、维生素 E三种药物可升高晶状体钠泵α亚单位在 mRNA水平的表达，从细胞形态和超微结构上的表现，提示了其对晶状体有保护作用或抗损伤效应。3、药物作用于晶状体钠泵具有重整异构特异性，提示了开发出特异的具有重整异构作用的药物是极有临床应用前景的。4晶状体钠泵抑制后可能导致白内障的发生，故临床用药，尤其是心内科医生在使用这些钠泵抑制剂时应注意调整用药剂量及药物疗程。5 通过抑制晶状体钠泵来制作白内障动物模型能否成为一种经典的制作方法，还有待于进一步研究。

The difference as regards the latency and duration between EAP and EAU seems to show that the pineal gland is more susceptible to retinal autoimmune reac- tions than retina and uvea, indicating that one mechanism or factor for"ending inflammation"presents in ocular tissue rather than in pineal glands.

特异性抗体出现于EAU发生之前，EAU发生于特异性抗体上升阶段，提示体液免疫反应在其发生中起着一定的作用，而特异性Th细胞的激活及其所产生的IL-2，则可能对EAU的发病有更为重要的作用。

The inhibition of it achieved about 30% at presenting of CLAM.The proper- ty of climacteric in apple is that the pathway of respiration turns from cytochrome pathway to CN-resistent pathway when apple fruits come in riping;moreover,th...

当在CLAM存在下进行陈化时，苹果诱导呼吸的发生被抑制约30％，跃变期果实的特点是当果实进入成熟期时呼吸途径发生了由细胞色素途径向抗氰的交替途经转移的现象；同时其果实切片在陈化后可以发生诱导呼吸。

The fusing of bone marrow stromal cells and neuronal cells results in the change of cell phenotypes.

骨髓间质细胞与神经元的融合导致细胞表型发生变化。

Within the cell, further division of labor occurs between the organelles.

在细胞内，进一步的分化发生在细胞器之间。

Moreover, re-expression of FHIT in FHIT-deficient cancer cell lines induced apoptosis, cell cycle arrest, and suppression of tumorigenity in nude mice reviewed in ref.

FHIT蛋白在FHIT缺失肿瘤细胞系中的重新表达可诱发裸鼠发生细胞凋亡，细胞周期停滞，并抑制了肿瘤生成。

Moreoer, re-expression of FHIT in FHIT-deficient cancer cell lines induced apoptosis, cell cycle arrest, and suppression of tumorigenity in nude mice reiewed in ref.

FHIT蛋白在FHIT缺失肿瘤细胞系中的重新表达可诱发裸鼠发生细胞凋亡，细胞周期停滞，并抑制了肿瘤生成。

As a special kind of macrophages, Kupffer cells also play a two-way role in the development of liver cancer.

作为一类特殊的巨噬细胞， Kupffer细胞在肝癌发生发展中同样起着双向作用。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。