细胞发生

Apolipoprotein D is a member of the lipocalin family. ApoD can bind small hydrophobic molecules such as cholesterol and arachidonic acid, etc. It also plays a role in many physiological and pathological processes such as development and differertiation of embryo, apoptosis of cancer cells, immune defense, and so on.

载脂蛋白D属于脂蛋白家族，和该家族的其它成员一样，其基本功能是转运一些脂类的小分子物质，还参与胚胎的发育、分化；肿瘤细胞的发生、发展和凋亡；免疫性反应；抵抗外界环境胁迫以及神经系统的发生和损伤修复。

To continue the previous work from our laboratory, the purpose of this study is to investigate IGFBP-5 gene expression by BP and ripen areca nut extract in NHOKs . The results in this study suggest that BP and rANE exhibited inhibition effects on IGFBP-5 gene expression both on transcription and translation levels in NHOKs .

本研究发现， BP 及老槟榔萃取物对於正常口腔角质细胞中 IGFBP-5基因之表现均有抑制之效果，且此抑制效果不但发生於基因转录阶段，甚至还持续到转译阶段；类似的结果也在 SCC25细胞中观察到。

The differential expression profiles of 588 known genes were determined using Atlas human cDNA expression array. Fifteen genes were differentially expressed following the overexpression of BNIPL-1. Most of them were involved in cell proliferation or cell apoptosis. Furthermore, the differential expression result was confirmed by semiquantitative RT-PCR.

然后采用人Atlas cDNA expression array对新基因BNIPL-1在细胞内的下游调控事件进行了初步研究。588个已知基因中有15个的表达发生了改变，其中大部分是细胞生长和凋亡相关基因，半定量RT-PCR验证了杂交结果的可靠性。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

In the present study, the mechanisms of how EGCG enhanced ATO cytotoxicity in leukemia cells were investigated.

结果显示EGCG和三氧化二砷并用可以显著地诱导白血病细胞中过氧化氢和细胞凋亡的发生。

However, these effects occur mainly in cells cultured on basement membrane due to the permissiveness of insulin signaling in these cells.

这些影响大部分发生在培养在基底膜的细胞，主要是因为这些细胞能够传递胰岛素的讯息。

There were 8 embryos single blastomere amplified, and the amplification success rate was 72. 7%(8/11); 3 embryos' not amplified; 2 embryos'showed preferential amplification , and the PA rate was 25%(2/8); and the 7 tubes of blank with washing cell solution were not contaminated. We transferred 3 unaffected embryos to the uterus. But unfortunately, blood hCG was negative after 2 weeks of transferring indicating no pregnancy.

共8枚胚胎的单卵裂球得到扩增，扩增成功率为72.7%（8/11），3枚未得到扩增，2枚发生了偏性扩增(preferentialamplification，PA)，PA的发生率为25%（2/8），细胞洗脱液空白对照7管均无污染发生。3枚诊断为正常的胚胎被移植入宫内，不幸的是，移植后2周，血hCG阴性，证明未妊娠。

It is concluded that the initial ancotomic site of blood island genesis may be is mesoblast of extraembryonic blastoderm rather than the yolk sac; the blood vessel endothelium cells and the blood cells are generated parallel; the PGCs are the common ancestry of angioblast and HSC.

血岛最早发生的解剖位置可能不是卵黄囊而是胚外胚盘中胚层，血管内皮细胞与血细胞平行发生，PGC是成血管－造血干细胞的共同祖先。

Lymphocyte blastogenesis and T lymphocyte population were analysized 1 d after the LPS administration,gene expression of IL-2 and IFN-γ was quantified by RT-PCR technology.

注射LPS使肉仔鸡发生了以细胞免疫为主的应激反应，皮质酮和T3水平、T4／T3比值及细胞因子mRNA表达量均能作为衡量免疫应激的敏感指标；免疫应激是相对于正常状态而言的，就其本身来说，尚无法衡量程度的高与低。

Once these reactive these reactive oxygen species cannot be eliminated, cells will be damaged and leads to membrane morphological changes, such as the bleb formation.

在细胞受到氧化伤害的过程中，常可观察到细胞表面发生特殊的形态变化，即所谓发泡现象。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。