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Results showed that there were the morphological changes of mitochondria, such as vacuolization, degeneration and cristae swelling or disappearance, in HT-29 cells treated by C2-ceramide for 24 hours. Under the fluorescence microscope, mitochondria of apoptotic cells aggregated and emitted red fluorescence, however, mitochondria of normal cells emitted green fluorescence. The mitochondrial membrane potential began to decrease after 6 hours in HT-29 cells treated with C2-ceramide in time and dose dependent manner.

结果显示C2-神经酰胺作用HT-29细胞24小时,线粒体发生空泡化、变性、嵴肿胀或消失等形态学改变;此时荧光显微镜下可观察到线粒体聚集,发出红色荧光,而正常细胞线粒体发出绿色荧光。C2-神经酰胺作用细胞6小时,线粒体膜电位即开始降低,呈时间-剂量-效应关系。

The results showed that: at metaphase I, the homoeologous chromosome pairing among different F1 hybrids ranged from 2.0 to 11.4 bi-valents formed by homoeologous chromosomes per pollen mother cell, and very few multivalents, and even very few bivalents were formed by two chromosomes within one genome rather than homoeologous chromosomes in some PMCs; at anaphase I, all biva-lents were disjoined and most univalents were divided.

结果表明在中期I阶段,这些杂种一代的近缘染色体联会变化很大,每个花粉母细胞中二价体形成的数目从平均2个到11.4个不等,甚至在某些花粉母细胞中,还发现极少的多价体和非部分同源染色体所形成的单基因组内二价体;在后期I时,所有的二价体分离,同时多数单价体也分离,分离的二价体和分离的单价体都移向两极,从而形成两组染色体;因为这时完整花粉母细胞中分离的二价体在两组染色体中总是对应出现,从而根据半二价体上染色体重组的位置可以分析在二价体的四分体时期发生在非姊妹染色体之间的多种染色体交换类型,如单交换、三线双交换、四线双交换、四线三交换和四线多交换。

Further study demonstrated that peroxynitrite also induced tau nitration in neuroblastoma N2a cell line, and the nitrated tau was accumulated in the cells.

进一步研究发现:用PN处理稳定表达tau蛋白的N2a细胞,可以诱导细胞内tau蛋白的硝基化,而且硝基化的tau蛋白在细胞内发生聚积。

When cells are stimulated by apoptosis factors, TR3 is induced rapidly and then translocates from the nucleus to the cytoplasm, in which it targets to the mitochondria,inducing apoptosis.

当细胞受到凋亡因子刺激时,TR3表达提高并从细胞核转运至线粒体诱导细胞凋亡。本文研究发现,RXRα可以在胃癌MGC80-3细胞中发生核浆穿梭转运,并且具有能量依赖性的特性。

VE-cadherin moved away from the transmigration site to different ends of it, whereas PECAM-1 opened to surround the periphery of a transmigrating PMN.

我们发现在PMN穿过内皮细胞层时,这两种连接体蛋白都不会突然消失,而是发生了渐进的相对移动--相邻内皮细胞间原本彼此接合的VE-cadherin会沿著细胞间的界线移向PMN两端;而PECAM-1的变化则是打开原本彼此间的键结,改而围绕在PMN周边。

Results: Gastric cancer cells stabilized to culture plate by the process of forming...

结果:胃癌细胞首先发生形态学变化,细胞伸出伪足与培养盘和其他细胞接触形成稳定状态,在此过程中整合素β1在细胞膜的伪足部分的表达增强,并形成集落团块。

METHODS: The presence and number of recently developed extra-articular manifestations and a weighted EAM score, as well as the levels of serological markers, were compared between 31 patients with RA with histologically proven vasculitis and 50 patients with RA in whom vasculitis could not be documented histologically. The following markers were evaluated: circulating immune complexes, complement components C3 and C4, class-specific rheumatoid factors, antineutrophil cytoplasmic antibodies, antinuclear antibodies, antiendothelial antibodies, circulating intercellular adhesion molecule-1 and -3, circulating vascular cell adhesion molecule and E-selectin, cellular fibronectin, von Willebrand factor antigen, and C reactive protein.

对比组织学上已证实有血管炎的31例 RA 例和组织学上无血管炎的50例 RA 患者间的临床及血清学标记物,这些资料包括最近发生的关节外表现数量、关节外表现加权得分、循环免疫复合物、补体 C3和 C4、类风湿因子( IgM-RF,IgG-RF,IgA-RF )、抗中性粒细胞胞浆抗体、抗内皮细胞抗体、循环细胞间粘附分子-1和-3、循环血管内皮粘附分子和 E-选择素、细胞纤连蛋白、假性血友病因子抗原( von Willebrand factor antigen )及 C-反应蛋白。

Results: The animal experimental model indicates the facial nerve' s bone canal fracture can make the facial nerve hyperaemia, strut, and putrescence, denaturalization and with the Schwann cell and the cell become more and more, taking on the restore evidence.

结果 动物实验表明:面神经骨管骨折后,面神经发生充血肿胀,并出现脱髓鞘、变性及坏死的变化,伴随神经损伤的同时出现巨噬细胞和施万细胞增生肥大及纤维母细胞的增生,呈现修复迹象。

Resembled to control oocytes, MAPK was inactivated after cytoplasts activation. However, after activation the cytoplasts showed fragmentation while pronuclei were formed in the control oocytes. This indicated that nuclei play important role in maintainence of oocytes normal morphology.

成熟胞质的活化与卵母细胞相似,在活化后MAPK被迅速灭活,只是胞质在活化处理后均发生碎裂,而卵母细胞活化后形成原核,这表明核在细胞形态维持中起重要作用。

DNA ploidy can more really reflect the content of DNA,which has long history in the relation study with tumor.

肿瘤细胞的重要生物特性是无限制增值,这个过程需要合成大量的核酸来完成,也使得细胞内的DNA含量发生变化,肿瘤细胞的DNA含量异常,是恶性肿瘤的重要标志。

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