细胞发生

These indicated that endothelial cells of the mural coronary artery are free from atherosclerosis due to higher shear stress caused by myocardial bridge. The intima of the section proximal to mural coronary artery was likely to be sclerosed due to the lower and oscillatory shear force.

提示 壁冠状动脉内皮细胞受到心肌桥压迫导致血流切变力增高产生适应性反应，对内皮细胞有保护作用，而其近段内皮细胞由于切变力较低容易被损伤，成为动脉粥样硬化发生的基础。

The major changes include sparse and short and loose microvilli of endodermal epithelium cells, a reduction in apical microvesicles and subapical storage vacuoles, swilling of the mitochondria and a reduction or disappear in its cristea, a decrease in rough endoplasmic reticulum, abnormation in pattern and structure of nucleus, an increased vacuolation in cells, an extend in the interval of adjacent cells.

电镜观察发现，剂量在50g/mL以上时，YS上皮细胞微绒毛稀疏变短，胞质中贮液泡减少，线粒体、内质网等内膜系统发生多种细胞病理学改变，细胞间隙增宽，连接复合体破坏。

There were no significant differences for the firing rates in the site of contralateral TNC neurons among during pre-CSD,CSD,and post-CSD (P＞0.05).For flunarizine group,the firing rates in the site of ipsilateral TNC neurons during pre-CSD were higher as compared with during CSD(P＜0.05).2.1 There were statistical differences on palasma levels of CGRP and SP among the three groups(P＜0.05).The levels of CGRP and SP in CSD group were higher than control group(P＜0.05).No significant differences on the levels of CGRP and SP in ipsilateral trigeminal ganglia were found among the three groups(P＞0.05).2 The number of neurons with positive CGRP and SP immunoreactivity was statistically different in right-sided trigeminal ganglia among the three groups (P＜0.05).The number in fight-sided trigeminal ganglia in CSD group was higher as compared with control group(P＜0.05).The number in right-sided trigeminal ganglia was statistically higher than that in left-sided trigeminal ganglion in CSD group(P＜0.05).3.1 Altered ReHo in ipsilateral pons and other brain regions response to pain such as basal nuclei,thalamus,cingulated gyms and prefrontal cortex was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation). 2 Positive functional connectivity was detected between ipsilateral pons and other brain regions related to pain within pain state and within non-pain state (P＜0.05,corrected by false discovery rate,FDR).Increased functional correlation between ipsilateral pons and other pain-related brain regions such as ipsilateral prefrontal cortex and contralateral subcallosal gyrus was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation).

结果1。对照组未发现CSD；同侧TNC放电频率，CSD中＞CSD后＞CSD前P＜0.05对侧TNC放电频率，CSD前、中、后无统计学差异(P＞0.05氟桂利嗪组同侧TNC放电频率，CSD前＞CSD中(P＜0.05)，CSD前与CSD后及CSD中与CSD后之间无统计学差异(P＞0.05)。2.1关于放免测定，各组血浆CGRP、SP水平有统计学差异(P＜0.05)，CSD组高于对照组(P＜0.05)，CSD组与氟桂利嗪组、对照组与氟桂利嗪组之间均无统计学差异P＞0.05各组之间同侧三叉神经节中CGRP、SP水平未见变化(P＞0.05.2关于免疫组化研究，右侧三叉神经节CGRP、SP免疫阳性细胞数三组之间有统计学差异(P＜0.05)，多重两两比较结果CSD组大于对照组(P＜0.05)，CSD组与氟桂利嗪组之间、对照组与氟桂利嗪组之间无统计学差异P＞0.05左侧三叉神经节CGRP、SP免疫阳性细胞数三组之间无统计学差异(P＞0.05CSD组中右侧三叉神经节CGRP、SP免疫反应阳性细胞数大于左侧(P＜0.05)。3.1局部一致性分析发现两组患者头痛疼痛状态较非疼痛状态脑活动发生变化的脑区有同侧脑桥以及其他疼痛相关脑区如基底节区、丘脑、扣带回、前额叶皮层等(P＜0.05，蒙特卡罗模拟校正)。2功能连接分析发现疼痛状态与非疼痛状态下主要疼痛相关脑区均与同侧脑桥有功能联系P＜0.05，false discovery rate，FDR校正疼痛状态与非疼痛状态比较，同侧前额叶皮层、对侧胼胝下回等疼痛相关脑区与同侧脑桥之间功能联系增强(P＜0.05，蒙特卡罗模拟校正。

There were significant differences between all the experimental groups and the control group (F=193.25, P＜0.01). Conclusions IL-1β and TNF-α induce a strong expression of MCP-1 mRNA and protein in HUVECs. Both cytokines may be involved in the atherogenesis by inducing the liberation of MCP-1 by endothelial cells and increasing the recruitment of monocytes into the subendothelial space.

IL-1β和TNFα均能显著增强内皮细胞MCP-1 mRNA和蛋白的表达，提示它们通过诱导内皮细胞产生MCP-1，吸引单核细胞迁入动脉内膜而参与动脉粥样硬化的发生和发展。

Supervital NBS staining Nile Blue Sulphate , a lysosomotropic vital dye which stains embryonic apoptotic, but not necrotic cell death, is employed to identify the occurence and location of apoptosis.

活体胚胎的NBS染色 NBS是一种亲溶酶体染料，可使凋亡细胞着色，而坏死细胞不着色，因而可初步判定细胞凋亡发生的区域和程度。

To study the activation mode of LFA-1 on the NK cell surfuse, a platform based on optical tweezers was constructed to observe the molecular behavior of LFA-1. According to the results, the adhesion force between an NK cell and a polystyrene microsphere coated with anti-LFA-1 antibody was confirmed to be time-dependent.

我们利用光镊研究了NK细胞表面LAF-1的单分子行为，发现NK细胞与包被了LFA-1抗体的小球之间的结合力随二者接触时间的延长而增强，表明NK细胞表面LFA-1分子可能会受LFA-1抗体影响而发生局部聚集。

The arise of Ang II was found in thecal cells specially, the reason could be due to an abundance of blood vessels in the thecal cell layer, but not in the granulosa layer. E2, P, T may play very important roles in the follicle development and atresia.

RAS的变化主要发生在卵泡膜细胞，可能与卵泡膜细胞层具有丰富的血管而颗粒细胞层中无血管有关。E2、P、T具有不同程度的促进卵泡发育和抑制闭锁的作用。

The results of the determinating the activity of the CA in vitro showed that the CA of the water—fed individuals were in activing statics after eclosion. Because of the apperence of the Vg in haemolymph and the deposition of the vitellin in oocytes in the unfed females, it was shown that the CA in such individuals were in activiting statics, too. Again because in the water—fed females which did not lack the feeding action the activity of the CA showed dropping tendency gradually still, it could be said that the activiting of the CA was possibly effected by the nutrition but it was never related to the adult feeding action. In another respect, the brain of the female adult had not significant effect on the activiting CA. The oocytes could depositing vitellin in individuals removed brain tissue on the day of eclosion, which showed that the activting of CA was not concerned with brain.

CA活性的体外测定说明饲水个体的CA同样具有活性，不取食个体血淋巴中Vg的存在以及卵母细胞中卵黄的沉积表明，在不取食的个体中CA同样具有活性，所以CA的活化与成虫期的取食动作无关，与成虫是否取食花蜜也无太多的联系，但是CA活性的维持可能受成虫期营养的影响，如果以卵母细胞发育和CA体积大小作为CA活性的指标，则饲水个体CA的活性在后期受到了影响，说明饲水不能替代取食蜂蜜来维持成虫期CA的活性；成虫期脑对CA的活化无明显作用，羽化当日摘除脑的个体，其卵母细胞仍然可以沉积卵黄，说明CA的活化与脑无关，而是受某种不确定的因子的影响；用抗JH物质—早熟素—Ⅱ以10ug／虫的剂量在颈部点滴处理雌虫，对Vg的发生和卵巢的发育具有一定的迟缓作用，其原因有待于进一步的研究。

The reacting tite with NDPK-A was 1:800 and theantisera was specific.Conclusions: The purified rhNDPK-A protein exists mainly in the form of hexamer;rhNDPK-A protein can promote the survival of spleen cell and may take part in theadjustment of cell growth by the way of changing cell cycle.

ELISA法检测所制备的抗体的反应效价为：1：800，western blotting试验结果证实，该抗血清具备较好的特异性，能与rhNDPK-A蛋白发生反应，结论：rhNDPK-A蛋白可能主要以六聚体形式存在，直接观察的蛋白结构与文献报道的X衍射结果相似；rhNDPK-A蛋白对正常小鼠的脾细胞的存活有促进作用，推测很可能以信号转导的方式调控细胞周期从而达到对细胞生长的调节作用。

To explain relationship between the effect of CLD on senile Demention and neuron in hippocampal area. The change of natural aging mice's neuron in hippocampal area were studied by applying microscope and transilluminating electric microscope. Results: Comparing with the young control, the old control mice's hippocampus had less small pyramid cells, the nerve cells denaturalizing and their branches reducing in the microscope. Hippocampal nerve cells were degenemiceing, with nucleus membrance crinkling like wave shape were not clear, and chromatin condensing with high electron density, heterochromatin accruing, part cell organs inclosing nucleus, nucleus condensing in the EM.

为了阐明菖龙丹抗老年性痴呆作用与海马区神经元结构的关系，运用光镜和透射电镜观察了菖龙丹对自然衰老小鼠海马区形态的影响，结果显示老年对照组小鼠光镜下海马锥体细胞较青年对照组数量减少，细胞体积变小，神经元变性，分枝减少；电镜下海马神经细胞发生退化改变，核膜皱缩，呈波浪状，膜结构不清晰，核染色质浓缩，电子密度高，异染色质较多，部分胞浆细胞器向细胞核聚集，有的可见细胞核固缩。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。