细胞原质的

In the pathological proceeding of pulmonary fibrosis, myofibroblast plays an important role, such as: the abnormal extracellular matrix deposition causing by the remarkable capability of collagen synthesis, derogation of the lung compliance owning to the contractibility of myofibroblast,secreting many cytokines,which contribute to the damage of the alveolar epithelial cells.

肌成纤维细胞在PF的病理进程中扮演着重要的角色，其胶原合成能力强可造成细胞外基质的异常沉积、具收缩性使肺顺应性下降、分泌多种炎性介质加重肺泡上皮损伤。

OBJECTIVE: To find the difference of gene sequence between human and porcine ECM and to identify the ECM immunogenicity based on bioinformatics.

目的：通过生物信息学的方法找到人与猪细胞外基质蛋白的基因序列差异，并制备抗体验证基质的免疫原性。

RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病，1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖；应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia；一色恤~﹁染澎糕行HE染色观察组织病理学孪叱；胶质细胞原纤维酸性蛋白protellZ，Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分，应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

Astragali many candies can be promoted into hyperplasia and collagenic formation of fibrous cells within the range of certain density, the ones that strengthened the wound ground substance are synthetic in order to promote the wound to heal.

细胞实验结果显示：黄芪多糖在一定的浓度范围内可促进成纤维细胞的增殖和胶原的合成，增强创伤基质的合成以促进伤口愈合。

The gene regulating sequence of human collagen type Ⅰ is located at 5'end and first intron. The carriers of reporting gene was made, and the function of promoter, enhancer and inhibiter was examined in this study. On the basis of above work, MBP ectopic expression carriers were further built. The result laid a foundation for investigating the feasibility, and validity to specially express MBP gene of human nervous system, in tendon fibroblast.

人Ⅰ型胶原基因调节序列位于5'端和第一内含子，本研究构建了带报告基因的载体并检测了其启动子，增强子和减弱子的功能，以此为基础，进一步构建了MBP异位表达载体，为探索在神经系统少突胶质细胞特异表达的人脑髓鞘碱性蛋白MBP基因转至肌腱成纤维细胞表达的可行性和有效性奠定了基础。

M. penetrans can stimulate the production of NO and inhibit mouse macrophages prolification, thus it may be an important etiological factor.

穿透支原体的脂质相关膜蛋白能诱导巨噬细胞产生一氧化氮，且能抑制巨噬细胞的增殖，因而可能与其致病性相关。

Therefore, collagen metabolism is the center of the extracellular matrix remodeling in intracranial saccular aneurysms, while the essence of the remodeling process is a kind of autoimmunological and inflammatory reaction.

因此，胶原代谢是囊性动脉瘤细胞外基质重塑的核心内容，而重塑过程的实质是一种以细胞免疫为主的免疫炎性反应。

Results The feeder layers of bone marrow stromal cells allowed spermatogonial stem cells to proliferate well and remain undifferentiated.

结果 原代的小鼠培养骨髓基质细胞能很好的维持精原干细胞的非分化性扩增。

To master fluid mosaic model of cell membrane;peripheral proteins and integral proteins;the type of extracellular matrix;Collagen;glycosaminoglycan and proteoglycan;elastin; Occliding junctions;anchoring junctions;desmosome hemidesmosome、the structure and function of adhesion belt and focal adhesion;cell coat;cadherins;selectin;Ig-superfamily; integrins

掌握生物膜的流动镶嵌模型；膜周边蛋白和膜内在蛋白；细胞外基质的类型；胶原纤维；糖胺聚糖和蛋白聚糖；弹性蛋白；封闭连接；锚定连接；桥粒与半桥粒、粘着带与粘着斑的结构与功能；细胞外被；钙粘素；选择素；免疫球蛋白超家族；整联蛋白

Transmission electron microscopy demonstrated that fibroblast was full of endoplasmic reticulums that cisternal-like expanded in the rhEGF nanoparticle group, and collagen proteins were synthesized in cavity.

透射电镜下可见rhEGF纳米微球组成纤维细胞胞质内有大量的内质网，扩张成池状，腔内充满了合成的胶原蛋白。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。