细胞原癌基因

We carried out a primary study of shear stress activated K+ channel in osteoblast by using clamp patch technology .

研究原癌基因表达与剪应力的关系对于了解细胞通过何种途径将剪应力信号的刺激传入细胞内并引起一系列的细胞应答，对于进一步认识流动剪应力作用对成骨细胞功能、代谢等产生的影响都有重要的意义。

The transitional cell carcinoma of the bladder is liable to plant and recrudescence.

本研究选取COX-2、原癌基因HER-2、抑癌基因p53进行探讨，目的在于了解COX-2，HER-2，p53在膀胱移行细胞癌发生发展中其蛋白产物表达情况以及它们可能存在的相关性，以期对膀胱移行细胞癌的诊断、预后、监测、治疗提供一定理论指导作用。

Expression of epidermal growth factor receptor in breast can- cerin relation to steroid hormone receptors and prognosis. Epider- mal growth factor receptor is a transmemberane protein encoded by the oncogene c-erbB-1. It presents in all types of tumor cells and certain normal tissues, and it is thought to be related to cell carcinogenesis and uncontrolled cell growth.

表皮生长因子受体（Epidermal growth factor receptor，EGFR）是原癌基因c-erbB-1的表达产物，它是一种细胞膜受体，广泛存在于各种类型的肿瘤细胞和某些正常组织细胞中，与细胞癌变和失控性生长趋势有关。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

MEN1 is characterized by parathyroid adenoma, gastroenteropancreatic and anterior pituitary tumors. MEN2A and MEN2B are characterized by medullar thyroid carcinoma, pheochromocytoma, parathyroid hyperplasia and mucosa neurofibroma, respectively.

多内分泌腺瘤病2型(MEN2)主要由原癌基因RET突变所致，又分为MEN2A和MEN2B，临床表现为甲状腺髓样癌、嗜铬细胞瘤、甲状旁腺增生和黏膜神经纤维瘤。

The article focuses on the aberrant expression and significances of proto-oncogenes, tumor suppressor genes and genes associated with the proliferation process of gastric cells such as telomerase, transcription factor and cyclooxygenase, etc. These genes, alone or synergically, participate in gastric cancer cell proliferation, resulting in an uncontrolled growth characterized by over-proliferation of decreased apoptosis of gastric cancer cells.

本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子、环氧化酶等基因以及参与细胞周期调控的原癌基因、抑癌基因的异常表达及临床意义，这些基因或单独作用，或相互协同，参与胃癌细胞的增殖，使肿瘤细胞生长以增殖过多、凋亡过少的失控性生长为特征。

Unmutated proto-src coding region is tumorigenic if expressed from the promoter of Rous sarcoma virus: implications for the gene-mutation hypothesis of cancer.

他反对癌基因学说的关键是基因表达量的问题，也就是他认为细胞原癌基因要致癌必须获得类似病毒启动子的强力转录力量

Phagocytes play a key role in inflammation and are the main source of IL-1, TNF and oxygen free radicals.

HSPs可通过结合原癌基因与抑癌基因产物影响细胞的增生与转化。

The expression of C-myC oncogene was studied at the protein level incells obtained from 10 patients with leukemia.

C一myC癌基因是在肿瘤细胞中普遍表达的一种原癌基因，是对细胞增殖和分化起重要作用的基因。

The chip used contains 4097 genes covering oncogenes and tumor suppressor genes, the genes related to ion channels, cell cycle proteins, outer force reaction proteins, cell skeleton and movement, and apoptosis, the genes associated with DNA synthesis, repair and recombination, the genes related to DNA combining and transcription, the genes encoding cell receptors, the genes related to signaling, the genes associated with immune response, metabolism, protein synthesis, development and others.

实验所用的芯片含有4097个基因，包括原癌基因和抑癌基因、离子通道和运输蛋白基因、细胞周期蛋白基因、外压反应蛋白基因、细胞骨架蛋白和运动相关基因、细胞凋亡相关蛋白基因、DNA合成和修复和重组相关蛋白基因、DNA结合和转录和转录因子基因、细胞受体基因、免疫相关基因、细胞信号传导蛋白基因、代谢相关蛋白基因、蛋白质翻译和合成相关基因、发育相关基因、及其它基因。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。