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The journal publishes original articles and clinical reports on scientific investigations and new developments in laboratory medicine in animals, including hematology, coagulation, immunology, clinical chemistry, endocrinology, cytopathology, surgical pathology, laboratory methods, quality assurance and instrumentation.

杂志刊载实验室动物医学的科学研究和新发展原始论文和临床报告,包括血液学,凝固作用,免疫学,临床化学,内分泌学,细胞病理学,外科病理学,实验方法,质量保证和仪器。

Essential amino acid residues in diphtheria toxin catalytic domain were determined by quantum chemistry calculation and the enzymatic activities of mutant in the active-site were tested in order to provide high effective cytotoxin for target anticancer drugs.

通过量子化学计算确定白喉毒素分子催化区活性中心的关键氨基酸残基,评价其取代后的酶活性的改变,为导向性抗癌药物研究提供高效杀伤细胞工具。

This institute setted up four scientific research organization: institute of biodiversity and ecological engineering, center for research and development of new drugs, institute of environmental and biological technology, center for research and development of dasheen, three departments: biology science, biological technology, biological resource and environment, four disciplines for undergraduate: biochemistry and molecular biology, ecology, cell biology and environment science, four disciplines for graduate: biology science, biological techonology, biological engineering and environment science.

学院现有生物科学、生物技术、生物资源与环境三个教学系和生物多样性与生态工程研究所、新药研究与开发中心、环境与生物技术研究所、魔芋研究开发中心四个科研机构;有生物资源与环境"211工程"建设国家重点学科和生物化学与分子生物学、生态学、细胞生物学、环境科学4个硕士学位点及生物科学、生物技术、生物工程、环境科学4个本科专业。

This paper was also studied primarily on the decolor of PHA. Physical and chemical methods were all used to decolor the organic phase after the recovery by CHC13 from the cells.

另外,本论文对PHA的脱色作了初步探索,实验就物理方法和化学方法针对氯仿提取细胞后得到的PHA有机相进行了脱色处理。

CeO2 is a cheap and of use wide material, it is used in optical materials. polishing agents. ultraviolet absorption materials. the cleaning catalyst of car waste gases. chemical decolorant of glass. radiation-resisting glass. permanent magnet. electronic ceramics etc. After it becomes nanoparticle, it will show some new properties and applications. For example, CeO2 nanocrystal is a better promoter of Cytochrome C and the stabilizer of Zr02 ceramics.

CeO_2是一种廉价而用途极广的材料,如用于发光材料、抛光剂、紫外吸收材料、汽车尾气净化催化剂、玻璃的化学脱色剂、耐辐射玻璃、永磁体、电子陶瓷等,纳米化后将出现一些新的性质及应用,如CeO_2纳米晶是细胞色素C的良好的促进剂,还用于ZrO_2陶瓷的稳定剂。

CeO22 is used as optical materials, polishing agents, ultraviolet absorption materials, the cleaning catalyst of cars waste gases, chemical decolorant of glass, radiation-resisting glass permanent magnet, electronic ceramics etc. If it is processed into nanoparticles, it will exhibit some novel properties led to varied applications.

CeO_2是一种廉价而用途极广的材料,如用于发光材料、抛光剂、紫外吸收材料、汽车尾气净化催化剂、玻璃的化学退色剂、耐辐射玻璃、永磁体、电子陶瓷等,其纳米化后将出现一些新的性质及应用,如ceOZ纳米晶是细胞色素C的良好的催进剂,还用作zro:陶瓷的稳定剂,由于ceo:折射率高,稳定性好,常用于制备减反射膜等。

Results Immunohistochemical staining SP methods can help to definitude the histological type and differentiation of astrocytic tumor.

结果:免疫组织化学标记能帮助鉴定组织类型和颅内星形细胞肿瘤的分化程度。

However, the in vitro directional differentiation of BMSCs into neuronal cells is easy affected by various factors.

但是在体外条件下通过化学和生物诱导物使骨髓间充质干细胞转化为神经元,影响骨髓间充质干细胞向神经细胞、胶质细胞系统定向分化的因素比较复杂。

RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病,1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖;应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia;一色恤~﹁染澎糕行HE染色观察组织病理学孪叱;胶质细胞原纤维酸性蛋白protellZ,Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分,应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

On creating model of cultured hippocampal neurons injured by amyloid, we studied the mechanisms of close interrelation between amyloid and Alzheimer"s disease at cell and molecular level with advanced test methods. For example, the technique of optical lens and electron microscope , immunohistochemical method,biochemistry.molecular biology and HPLC, so as to deeply probe into the mechanisms that Decotion of Rehamanniae prelects and treats Alzheimer"s disease.

本课题通过建立β淀粉蛋白损伤离体培养的海马神经元模型,运用光、电镜技术及免疫组化、生物化学、高效液相及分子生物学等先进的检测手段和方法,从细胞及分子水平进一步探索了Aβ与老年性痴呆发生、发展密切相关的综合机制,从而全面深入地探讨了地黄饮子防治AD的作用机理。

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