组织胞浆菌病

Histoplasmosis is a disease carried by bats and birds.

组织胞浆菌病是由蝙蝠和鸟类传播的疾病。

Slide 5-23 This is a case of disseminated histoplasmosis, one of the first cases ever recorded here in the Philippines.

幻灯5-23 这是在菲律宾报道的首例播散性组织胞浆菌病。

Fungi also cause lung diseases such as histoplasmosis.

真菌还引起肺部疾病，如像组织胞浆菌病。

PURPOSE: To define the role of intravitreal bevacizumab in individuals with choroidal neovascularization resulting from Ocular Histoplasmosis syndrome.

目的：明确玻璃体腔注射贝伐单抗在眼组织胞浆菌病综合症所致的脉络膜新生血管个体中的作用。

Methods: One case of histoplamosis with death, two cases with curing were reported and the clinical characteristics, diagnosis and therapy of histoplasmosis were discussed and the relevant literature was reviewed.

报告1例死亡、2例临床治愈组织胞浆菌病，并结合文献探讨该病的临床特征及诊治方法。

Key Words:Progressive disseminated histoplasmosis;Clinical feature;Diagnosis;Therapy

关键词］播散型组织胞浆菌病；临床特点；诊断；治疗

Interests: Emergency medicine, HIV/AIDS, Disseminating Histoplasmosis

兴趣：急诊医学，艾滋病毒/艾滋病传播组织胞浆菌病

Histoplasmosis: fever, weight loss, skin ulcers, difficulty in breathing, anemia, swollen glands.

组织胞浆菌病：发烧，体重下降，皮肤溃烂，呼吸困难，贫血，腺肿。

Research background: Choroidal neovascularization is a common cause of vision loss in patients, which often resulted from exudative Age-related macular degeneration、 pathologic myopia、 central serous chorioretinopathy、ocular histoplasmosis and angioid streaks, Rarely, CNV is seen in children, usually in association with inherited macular dystrophies. Despite extensive basic and clinical research, our knowledge of the complicated molecular mechanism of CNV is still limited, for these reasons currently used therapeutic approaches are insufficiently effective.

课题研究背景：脉络膜新生血管(choroidal neovascularization，CNV)是导致视力丧失的一种常见原因，多继发于渗出型年龄相关性黄斑变性、近视性黄斑变性、中心性浆液性脉络膜视网膜炎、眼组织胞浆菌病和眼底血管样条纹等眼病，在儿童罕见，主要与遗传性黄斑营养不良有关，尽管近年来进行了大量的基础和临床研究，但对CNV复杂分子机制的认识仍然非常有限，因此目前的治疗措施都不尽如人意。

One patient taking infliximab developed tuberculosis and one developed histoplasmosis. Five patients (four taking infliximab and one taking placebo) developed cancer. New autoimmune disorders developed in two patients taking infliximab and one patient taking placebo. Two patients developed optic neuritis and one developed a multifocal motor neuropathy; all three were taking the study drug.

英夫利昔单抗组1例患者发生结核病，1例发生组织胞浆菌病。5例患者(英夫利昔单抗组4例，安慰剂组1例)发生癌症。2例英夫利昔单抗组患者和1例安慰剂组患者新发自身免疫性疾病。2例患者发生视神经炎，1例发生多灶性运动神经病；这3例患者均服用了英夫利昔单抗。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失