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The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用,阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制,我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响;以Lewis肺癌自发性转移为模型,考察了托吡酯对肿瘤生长和转移的影响;同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响;检测了其对血管新生的作用;利用体外AQP1表达模型,研究了CA抑制剂对AQP1功能的影响;此外,用蛋白质组学的关键技术,通过对模型组与托吡酯治疗组血清蛋白质组的比较分析,来寻找与肿瘤转移相关的蛋白质,探索托吡酯的可能作用靶点。

Materials and Methods A total of 65 patients with gastric carcinoma were evaluated with triphasic spiral CT with water filling method and hypotonic agent.

资料与方法对65例胃癌行低张力水充盈螺旋CT三期增强扫描,所有病例均行手术切除,术后标本采用免疫组织化学SP法检测肿瘤组织中nm23-H1蛋白表达。

Among different organ explants from ginger lily, only sheaths and leaves cultured in VW medium containing 5mg/l 2, 4-D、0.5mg/l BA、3% sucrose and 200ml/l coconut water for 3 months could be induced to form embryogenic callus. It could produce lots of germinated or ungerminated somatic embryos per culture directly from the surface of calli after culture in MS medium containing 4mg/l BA and 0.05mg/l NAA. The shoots could develop into intact plants with vigorous appearance after 2 months in culture.

叶鞘及叶培植体在含5 mg/l 2,4-D,0.5 mg/1 BA、3%蔗糖及200 ml/1椰子水的VW固体培养基中,经3个月,可诱导产生具体胚分化能力之愈合组织;并於含4 ms/l BA及0.05 ms/l NAA之MS培养基中,直接由此愈合组织的表面产生数个至数十个数目不等之体胚,2个月后可形成一完整植株。

Various self-defense, joint-defense, livestock protection and other forms of joint-defense teams sprang up in various places to build roads, provide transport, dispatch mail, serve as guides, boil tea, send water, stand sentry and give first-aid to wounded PLA soldiers, effectively isolating the rebels.

他们主动配合人民解放军平息叛乱,各地群众纷纷组织自卫队、联防队、保畜队等自卫性组织,为平叛大军修路、运输、送信、引路、烧茶送水、站岗放哨、救治伤员,使叛乱分子陷于孤立。

The differences of the three chaperones between the two groups were all significant.

而且,它们在肺癌组织中的表达水平均明显高于癌旁正常肺组织。

The metallographic structure of melted mark was observed and metallographic structure with secondary short circuited melted mark and primary short circuited melted mark was found.

利用金相显微镜对火烧熔珠的金相组织进行观察,发现铜导线火烧熔痕在不同温度下经消防射水冷却后,会出现类似一次短路和二次短路熔痕的金相组织。

The second part of the thesis disserts the status of regulation mechanism of China 's city 4 water business, existing problems and the reasons, and the present different reform ways, and then suggests integrating water business.

第四章将联系实际工作,通过案例分析,对南京市城市水务一体化改革提出方案和建议。第五章是联系中国加入世界贸易组织,分析&洋水务&到来对一体化的冲击以及我们的对策。

First, the grain will be increase at double speed, second, a large scale "structure" builds by collision and coalescence of favorably oriented particles (namely primary phase coalescence), third, primary phase entraps the eutectic structure.

分别研究了浇注温度、拉坯速度、冷却速度等工艺参数对合金组织的影响,结果显示:在本实验条件下,浇注温度以650荀70'℃为宜;拉坯速度以8.4一9.6 cm/min为宜;二次水冷流量控制在1.0一2.0比为宜。综合考虑磁场强度B和冷却速度对非树枝晶组织初生相平均尺寸D和形状因子S影响的数学表达式为:D=A一ns二;。

Briefly, 100 mg of hypocotylar tissue was homogenized in 5 mL of water and the aqueous extract was used for the estimation of TP.

简单来说, 100毫克的hypocotylar组织匀浆在5毫升的水和水提取物被用作估计总磷。

The natural plant active factors enhance the immunity of involucra and horny cells, improve the blood circulation in capillary vessel, and strengthen the ability of water supply to skill cells.

浓缩的玫瑰精油,有效重建皮肤支撑组织,促进肌肤纤维蛋白的再生,天然植物活肤因子,可增强皮脂膜与角质细胞的防御力,改善毛细血管循环,增强肌肤细胞持久补水能力,达到肌肤水嫩柔光滑,永葆青春之目的。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。

A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。