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The results showed an increased mean jitter value, fiber density and abnormal percentage both in EDC and AT muscles in group 1 and II diabetic patients comparing to the normal controls. These findings suggest an impaired or immatured neuromuscular junctions and an evidence of reinnervation through axonal sprouting in the diabetic patients either with or without nerve conduction abnormalities. In conclusion, the changes of axonal degeneration and reinnervation are the main pathophysiological mechanism of diabetic neuropathy, and the SFEMG is more sensitive than routine nerve conduction study in the diagnosis of diabetic neuropathyKeyword Axonal degeneration , diabetes mellitus , neuropathy , single fiber electromyography

结果显示两糖尿病病患的连续间值差异,肌纤维密度及不正常比率比对照显著增加(t试验,依序p.01),在第一糖尿病患中,伸指总肌的连续波间值差异比第二高(p.05),而连续波间值差异与纤维密度之间也成线性相关的增加(伸指总肌,r=0.471,p.01;胫前肌,r=0.386,p.02),在伸指总肌测得的连续波间值差异上,第一糖尿病患有75%不正常,第二有33.3%不正常,而在胫前肌的连续波间值差异上,第一糖尿病患有83.3%的不正常,第二有75%不正常,在肌纤维密度的测定中,第一糖尿病患的伸指总肌有27.8%不正常,胫前肌有58.3%不正常,第二病患的伸指总肌有25%不正常,胫前肌有41.7%不正常,此结果表示糖尿病神经变造成的神经肌像交接处不稳定及有神经轴再生的重分布现象,因此也证实糖尿病神经病变的主要病理机转为神经的退化所致,而在诊断上单纤维肌电图检查的敏感度也比运动神经传导速度检查为高。

Methods Twenty-four Sprague-Dawley rats were randomly divided into 4 groups (n=6):① control group (inhaled 0.9% normal saline for 3 hours, twice every day);② enalapril self-control group 〔intragastrically administrated enalapril 0.5 mg/only〕;③ model group (stimulated with 4 mg/L acrolein for 3 hours, twice every day);④ enalapril interventive group 〔inhaled acrolein and intragastrically administrated enalapril 0.5 mg/〕.

健康雄性SD大鼠24只,随机分为4,每6只。A:空白对照;B:依拉普利自身对照,依拉普利0.5mg/灌胃;C:模型,大鼠吸入4mg/L丙烯醛,每次3h,每天两次;D:依拉普利干预(吸入丙烯醛+依拉普利灌胃),处理同模型,并给予依拉普利0.5mg/灌胃。21d后处死大鼠,采集标本。

Methods: Fifteen guinea pigs were randomly divided into 3 groups, in which the guinea pigs were peritoneally injected with normal saline, gentamicin, and both gentamicin and Egb (Egb+GM group). Distort production of otoacoustic emission thresholds were measured before and after injection. The apoptosis of hair cells were detected by TUNEL method.

健康豚鼠15只,随机分为3,I 为生理盐水; II 为庆大霉素,造成损伤模型; III 为银杏叶提取物和庆大霉素,观测3 豚鼠不同时期畸变产物耳声发射的改变, TUNEL法检测3豚鼠毛细胞凋亡。

The vein grafts with perivenous support by fibrin glue demonstrated a statistically decrease in neointimal and medial hyperplasia compared with non-supported vein grafts(p.01). immunohistochemical analysis showed that the expression of proliferating cell nuclear antigen was inhibited significantly in fs group compared with ns group. almost intact endothelium was showed in fs grafts(p.01). but in ns grafts there were severe endothelium damages where lymphocytes infiltrated. in ns grafts, the smooth muscle cells were hyperplasia and migrated to intimal, whereas in fs group, the hyperplasia of smooth muscle cells were inhibited and migrated to adventitia.

免疫化结果显示与ns相比,fs移植静脉细胞增殖核抗原表达明显受到抑制;ns内皮层损伤严重,有淋巴细胞侵润,而fs内皮层则几乎完好无损(p.01);在ns平滑肌细胞增殖活跃且向内膜迁移,fs平滑肌细胞增殖受到抑制,且向外膜迁移;在fs移植静脉外膜有丰富的成熟微小血管网形成,但是在ns,微小血管数量则非常少。

Results On the basis of the percentage of GPI-anchored PLAP conversion,the sera GPI-PLD activities of total 172 patients,included 26 severe acute viral hepatitis as group A,29 liver cirrhosis as group B,32 chronic viral hepatitis as group C,55 mild acute viral hepatitis as group D,30 primary hepatocellular carcinoma as group E,were measured.As compared with 182 healthy presons as control group,the sera GPI-PLD activities of group A and B were significantly reduced;By contraries,the activities of group D and E were significantly raised.The sera GPI-PLD activities of group C compared with healthy control group were not significantly altered.However,when paired Q-test,the changes of serum GPI-PLD activity between all paired groups among this five groups were remarkable.

结果检测172例肝脏疾病患者(包括A:26例急性重症病毒性肝炎;B:29例肝硬化;C:32例慢性病毒性肝炎;D:55例急性非重症病毒性肝炎;E:30例原发性肝癌)血清中GPI-PLD的活性,发现A、B两患者的该酶活性较正常人(182名)显著性降低,而D、E两则较正常人显著性增高,C患者的酶活性与正常人无显著性差异,但A、B、C、D、E两之间的酶活性水平改变却均有显著性。

Methods] 36 twomonthold rabbits with white feather and black eyes,half male and half female,were randomly divided into 6 groups:normal group,model group,xiangsha liujun pill group, lizhu changle group, lowdose leweiyintreated group,highdose leweiyintreated group.except the normal group, others were made into ibs model of spleen deficiency which was induced by damp heat stress and gavage with fanxieye as well as method of either hunger or gorge.the drug groups were administered preventively from the mediumterm of the model reproduction to the end of modeling.the rabbits of each group were observed.no,nos,mda,sod in serum and sp in colonic membrane were detected.

方法]两月龄白毛黑眼兔36只,雌雄各半,随机分为6:正常、模型、香砂6君丸、丽珠肠乐、乐胃饮低剂量、乐胃饮高剂量。除正常外,其余whbe兔采用湿热环境应激联合番泻叶灌胃加饥饱失常复合方法致脾虚泄泻型ibs模型。从模型复制的中期开始各用药预防给药,至造模结束。观察各1般情况,测定血清no、nos、mda、sod含量及结肠黏膜织中sp含量。

After SAH for 30 min, 1 h, 2 h, 6 h, 24 h, 72 h, 7 days and seven blank groups.

选用Wistar大鼠70只,建立大鼠蛛网膜下腔出血模型,随机分为蛛网膜下腔出血30 min、1 h、2 h、6 h、24 h、72 h、7 d,共7,每6只。

Results Patients who had at least one abnormal result of liver function test accounted for 70.99% in untreated group and 61.07% in treated group. The most common abnormal hepatic function parameter in patients with thyrotoxic hepatic lesion was increased alkaline phosphate enzyme, which was 57.3% in untreated group and 51.0% in treated group. Abnormalities of alanine transaminase, aspartate transaminase, gamma-glutamyl tyanspeptidase and total bilirubin were 28.2%(37/131), 18.3%(24/131), 10.7%(14/131) and 21.4%(28/131) in untreated group and 21.5%(32/149), 15.4%(23/148), 4.7%(7/149) and 20.1%(30/149) in treated group, respectively. The possibility of thyrotoxic hepatic dysfunction was correlated with the patients' age and FT3 and FT4 levels, but not with the genesis and course of disease, sex, family history of hyperthyroidism, or levels of TGAb and TMAb. Conclusion Abnormal results of liver function test are commom in patients with hyperthyroidism.

结果 在未治甲亢性肝功能损害的发生率为70.99%,经治为61.07%;甲亢性肝功能损害最常见的异常指标是碱性磷酸酶增高,未治、经治分别为57.3%、51.0%;血清谷丙转氨酶异常在两的发生率分别为28.2%、21.5%;血清谷草转氨酶异常在两的发生率分别为18.3%、15.4%;总胆红素异常在两的发生率分别为21.4%、20.1%;谷酰胺转肽酶异常的发生率未治和经治分别为10.7%、4.7%;甲亢性肝功能损害的发生与病程、甲状腺疾病家族史、性别、TGAb水平、TMAb水平无关,与年龄、甲状腺激素水平有关。

Five pieces of paleogeographic maps were made out with modern stratigraphic principles and sedimantary system method. It is shown by the maps that in the beginning of the Changzhougou time the Yanshan Region was occupied by alluvial environment with paleoriver flowing northeast, in the middle of the Changzhougou time a transgression changed whole Yanshan Region into shoreline-shallow sea environment gradually, and sedimentary boundary extended so continuously that by the Gaoyuzhuang time it had overpassed far beyond the Yanshan Region.

在缺乏良好等时面的情况下,本文依据现代地层学原理和沉积体系分析法编制了常州沟初期与中期,串岭沟初期,大红峪初期,及高于庄初期燕山地区的岩相古地理图,示意了燕山地区在长城纪时由冲积扇-河流为主的陆地环境向滨海-浅海环境的演变过程,并揭示了沉积区域不断扩大的趋势,表明常州沟初期,以蓟县-宽城为轴线发育了冲积相,海岸线可能在燕山以北,常州沟中期发生海侵,沉积区扩大至整个燕山地区,大红峪时海盆范围继续扩大,高于庄时,沉积边界已远远超出燕山地区。

Thomas II, M group (Mexibetine 70μmol/L+ st. Thomas II), HM group (HOE642 20μmol/L+ Mexibetine 70μmol/L+ st. Thomas II). The percent recovery of heart function and water content ofmyocardial were determined after I/R both in group A and B. C was composed of 4 groups (n=24, 6 in each group) as B but the dugs were added at the earlier period of reperfusion.

中,心肌进行缺血/再灌注后检测其心功能恢复率和心肌水含量。B(n=24,每6只)分为对照,H20(HOE642 20μmol/L),M(慢心律70μmol/L),HM(HOE642 20μmol/L+慢心律70μmol/L),加入心脏停搏液

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