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Results After the stimulation ,the rotating behaviour induced by apomorphine and improved distinctly, and DA content in the striatum increased (P<0.01), and Glu content reduced significantly ( P<0. 05).Content of the ASP had no change significantly.

结果 电刺激丘脑底核后,改善了PD大鼠的旋转行为,纹状体中多巴胺含量明显增加(P<0.01),谷氨酸含量明显减少(P<0.01),天门冬氨酸则无明显改变(P>0.05)。

Objective To explore the possibility of basic fibroblast growth factor and epidermal growth factor combined with st-riatal conditioned medium promoting the directional differentiation of rat bone marrow mesenchymal stem cells into dopaminergic neurons.

目的 探讨联合应用碱性成纤维细胞生长因子、表皮生长因子和纹状体条件培养液定向诱导大鼠骨髓间充质干细胞分化为多巴胺能神经元的可能性。

Interestingly, at E13.5, strong Foxp2-expressing differentiated striatal neurons were detected in region adjacent to SVZ, rather than in lateral part of MZ as in the control littermate.

有趣地,在胚胎期第13.5天,高量表现Foxp2的已分化纹状体神经元在近SVZ区被侦测到,而不是像同胎对照小鼠在MZ区外侧被侦测到。

Fetal neural tissues, such as ventral mesencephalon, striatum, and Schwann cells, were investigated for neurodegenerative diseases or spinal cord injury.

胚胎神经组织如中脑、纹状体和雪旺细胞在神经退行性疾病和脊髓损伤中的作用也有研究。

Objective To observe the role of genetically engineered myoblast in the treatment of rat Parkinson disease models.

目的 观察脑源性神经营养因子基因工程成肌细胞脑内纹状体移植对帕金森病大鼠的治疗作用。

ATUM-RE: This is Re as he emerged out of the Nun, appointed the Ogdoad to their proper places in the Heavens, and single-handedly created all in existance.

纹状体-重:这是因为他再度涌现出了尼姑任命ogdoad以适当名额老天爷,一手创造的一切存在。

Brain-derived neurotrophic factor is the most abundant neurotrophin in many parts of brain, such as pallium, hippocampus and so on.

脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)作为脑组织中含量最丰富的神经营养因子,在中枢神经系统内合成并广泛存在于脑组织,包括大脑皮层、海马、基底前脑、纹状体、下丘脑和小脑,其中以海马和皮层中含量最高。

Objective To evaluate the density change of dopamine transporterin striatum of C57BL mouse model of Parkinsonism.

目的 评价不同损毁程度C57BL小鼠帕金森病模型纹状体多巴胺转运蛋白的变化。

In experimental animals, exposure to a common herbicide, rotenone, induces features of Parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex Ⅰ.

例如,Greenamyre和他的同事在2000年报道了经大鼠颈静脉慢性灌流鱼藤酮复制了帕金森病的主要特征,包括选择性黑质纹状体多巴胺系统变性,Lewy小体样细胞浆包涵体形成和一些行为变化,例如运动减少和僵直等。从发病机制上考虑,鱼藤酮诱导的多巴胺神经通路损伤被认为是由鱼藤酮抑制线粒体复合体Ⅰ活性引起的。

ABSTRACT Aim and Methods: Using fast cyclic voltammetry and carbon fibre mi croelectrode, we monitored dopamine release from caudate putamen ,nucleus accumbens and central amygdaloid nucleus of normal rats in v ivo, in order to find out the suitable parameters to evoke DA release of certa in area. DA release was evoked by electrical stimulation of medial forebrain bundl e or ventral tegmental area.

目的和方法:采用快速周期伏安法在体研究电刺激内侧前脑束或腹侧背盖区诱发的纹状体、伏核或中央杏仁核多巴胺释放的特点,探索电刺激诱发不同核团DA释放的适宜刺激参数。

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