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RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum.

结果发现,纹状体6-OHDA注射不仅严重损伤了大鼠的运动功能,并且降低了RT任务过程中对各类事件产生反应的神经元数量。

Glutamate is the major excitatory neurotransmitter in the mammalian brain and key mediator of intracellular communication, plasticity, growth and differentiation. NMDA receptors is one kind of Glutamate receptors. The N-methyl-D-aspartate receptor is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits.

N-甲基-D-天门冬氨酸受体是一种门控离子通道复合物,作为兴奋性氨基酸受体之一,主要分布于大脑皮层、海马、纹状体等部位,是兴奋性氨基酸递质传递的重要基础,同时是维持中枢神经系统功能正常的关键因素。

In the pretreatment group, Bak Foong Pill extracts were given for 14 days prior to MPTP. Immunostaining of tyrosine hydroxythase was used to observe the damage of dopamine neurons, and of Bax to detect the protein levels of Bax. High performance liquid chromatography-electrochemical detection was used to investigate the contents of DA and its metabolites dihydroxy-phenylacetic acid and homovanillic in the Str.

给予BFP预处理后,用酪氨酸羟化酶免疫组织化学法观察黑质神经元的变化;同时应用免疫组织化学法检测Bax蛋白表达;应用高效液相-电化学方法检测纹状体巴胺及其代谢产物二羟基苯乙酸和高香草酸的含量变化。

In the pretreatment group, Bak Foong Pill extracts were given for 14 daya prior to MPTP. Immunostaining of tyrosine hydroxythase was used to observe the damage of dopamine neurons, and of Bax to detect the protein levels of Bax. High performance liquid chromatography-electrochemical detection was used to investigate the contents of DA and its metabolites dihydroxy-phenylacetic acid and homovanillic in the Str.

给予BFP预处理后,用酪氨酸羟化酶免疫组织化学法观察黑质神经元的变化;同时应用免疫组织化学法检测Bax蛋白表达;应用高效液相-电化学方法检测纹状体多巴胺及其代谢产物二羟基苯乙酸和高香草酸的含量变化。

In present study, levels of dopamine 〓 and 〓 receptors and expression of the protein mRNAs in striatum were exarmined by the methods of immuno- histochemistry and in situ hybridization, respectively. It was found that mice treated by paraquat taken orally for four months displayed a marked hypoactive behavior.

本研究以口服给予小鼠百草枯的PD模型,采用免疫组织化学、原位杂交结合计算机图像处理分析技术,观察百草枯对纹状体区多巴胺〓受体、多巴胺〓受体蛋白含量和基因表达的影响。

Objective: To observe the dynamic effects of treadmill pre-training on excitatory amino acid changes in striatum of rats with cerebral infarction and to explore the mechanism of pretraining protection to ischemic brain injury.

目的:动态观察预运动训练对大鼠脑梗死后纹状体处兴奋性氨基酸水平变化的影响,探讨预运动对缺血脑损伤的保护作用机制。

Similar to drug-addicted subjects, we found reductions in striatal dopamine D2 receptors in obese subjects.

与药物成瘾者相似,我们也发现肥胖患者的纹状体D2受体的减少。

RESULTS: Inosine decreased the size of KAinduced striatal lesion area and increased the number of NADPHd positive neurons.

结果: 肌苷可以使KA引起的纹状体损伤面积减小并增加NADPHd阳性神经元的数目。

MATERIALS: Healthy adult Wistar rats were selected for MSCs isolation, and newborn Wistar rats were selected for preparation of striatal conditioned medium.

材料:健康成年Wistar大鼠用于骨髓间充质干细胞的分离,新生Wistar大鼠用于纹状体条件培养液的制备。

Whereas the inductive effect of striatal neurons was very low and differentiation ratio was only 3%. The differentiation ratio of two groups had significant difference.

纹状体神经元条件培养液对ESC的诱导作用很弱,TH免疫阳性神经元的分化率仅为3%,二者具有显著性差异。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。