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The former, intracranially complements patients some factors, most frequently with TH gene to compensate scanty of intrastriatal DA and improve the symptoms of the patients, while have little resistance to the progressive degeneration of dopaminergic neurons; The latter provide variety of neurotrophic factors, most specific being the glial cell-line derived neurotrophic factor , to protect the residual DA neurons in the nigrostriatal system from further pathogenic injuries, while have little benefit to those DA neurons with irreversible damage, and them cannot offset the already-existing symptoms.

前者是给宿主脑内补充某些因子,主要是DA合成过程中的限速酶TH基因,以补充纹状体内DA含量的不足,减轻患者的症状,但对DA能神经元的进行性退变没有治疗效果;后者则是提供各种神经营养因子其中最具特异性的为GDNF,以保护黑质一纹状体系统内剩余的DA能经元免受病因的继续损害但对已发生不可逆性损害的DA能神经元并无拯救作用,无法消除已出现的症状。

The CGRP-positive fibers in the MrD of the striatum connected dorsally with the bed nucleus of the stria terminals through the stria terminals, ventrally with the amygdaloid nucleus, and caudally with the CGRP-positive cell bodies in the lateral part of the substantia nigra and its dorsolateral area.(4) The CGRP-positive fibers connected mainly with the central amygdaloid nucleus, and less with the medial amygdaloid nucleus; the CGRP-positive fibers in the lateral border of the caudate putamen connected mainly with the central amygdaloid nucleus as well.

并与边缘区的CGRP阳性纤维带之间存在较多的横向联系纤维;(3)纹状体边缘区的CGRP阳性纤维向背侧通过终纹与吻侧的终纹床核联系,向腹侧与杏仁核的CGRP阳性纤维相连,向尾侧和中脑黑质外侧部及其背外侧区的CGRP阳性胞体相连;(4)边缘区的CGRP阳性纤维主要与杏仁中央核相联系,少量与杏仁内侧核相联系;尾壳核外侧缘的CGRP阳性纤维也主要与杏仁中央核相联系。

Researchers have found that college students with relatively large striatums learned how to play a challenging video game faster than their small-striatum peers.

研究者发现,拥有相对较大纹状体的大学生能比有小纹状体的学生更快的学会玩一款有难度的游戏。

Those with larger striatums picked up the game faster, for example, and they shifted playing strategies more effectively than did students with smaller striatums.

那些拥有大纹状体的学生能比别人更快上手,比如他们能比小纹状体的学生更有效的切换战略。

Those with larger striatums picked up the game faster, for example, and they shifted playing strategies more effectively than did students with smaller striatums.

例如,纹状体较大的学生对该游戏领会得较快,并且他们跟纹状体较小的学生相比能够更加有效地变换游戏策略。

That could help answer the question of whether some people are born with larger striatums than others, or whether this region becomes bigger as people develop certain skills, says Yaakov Stern, a cognitive neuroscientist at Columbia University.

哥伦比亚大学的认知神经科学家亚科夫·斯特恩说,该研究可能有助于解决这个问题:某些人的纹状体是否在出生时就比其他人的更大呢?或者,人们是否在逐渐掌握了特定的技巧之后纹状体才变大的?

That could help answer the question of whether some people are born with larger striatums than others, or whether this region becomes bigger as people develop certain skills, says Yaakov Stern, a cognitive neuroscientist at Columbia University.

哥伦比亚大学的认知神经学家亚科夫·斯特恩认为,这项研究将有助于解答一个疑问,即有些人是否生来就有更大的纹状体,还是纹状体会随着人们某项技能的发展而逐渐变大。

Then NSCs were grafted into the striatums of PD rats with GDNF. Tyrosine Hydroxylase-positive cells were gradually increased at 30d after transplantation in the striatum of PD rats.

采用原代培养胚胎14.5天的胎鼠腹侧中脑NSCs,单独或经GDNF预处理后移植入PD模型大鼠的纹状体,观察NSCs在纹状体的分化情况,以及PD模型大鼠旋转行为的变化。

They were able to survive better and differentiate into TH〓 cells more strongly in 6-hydroxydopamine (6-OHDA)-lesioned striatums than in intact ones. Apomorphine-induced rotations were attenuated in MP grafted animals, too.

移植后发现,6-羟基多巴胺(6-OHDA)损伤的PD大鼠纹状体能促进MP或CP细胞的存活并分化成TH〓细胞,而且,MP双移植比单移植改善效果明显,也有助于黑质-纹状体DA神经通路的重建。

They were implanted thecannulas into the right striatums of rats according to the followingcoordinates:A:+0.2mm,L:+3mm,V:3.5mm and the microdialysates were collected andmeasured by HPLC-ECD 24h later. At the second step, 10 rats were divided intocontrol and model groups randomly.

第2批10大鼠在BMD和HPLC-ECD实验方法建立的基础上,随机分为对照组和模型组各5只,按照前述坐标定位至大鼠右侧纹状体,然后向模型组大鼠右侧纹状体内注入6-OHDA 12μg/4μl(用含0.1%抗坏血酸的0.9%氯化钠溶液配制)制作急性PD模型,对照组大鼠同一部位注射等量生理盐水。

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