纤维软骨的

Objective To analyze the effects of insulin-like growth factor-1(IGF-1) on reconstruction of femoral head and chondrification of articular cartilage from the periost and aponeurosis of the greater trochanter bone flap surface.

目的 观察分析大转子骨瓣表面骨膜及腱膜等纤维结缔组织向关节软骨转化的规律及胰岛素样生长因子-1（IGF-1）在软骨化生过程中的作用。

Chondromyxoid fibroma is a rare benign bone tumor. The etiology of chondromyxoid fibroma is still unknown.

软骨粘液纤维瘤是一种罕见的良性骨瘤，它发生的原因至今仍不明。

Mallory trichrism staining exhibited light blue samples. Eight weeks following repair, CT showed round blunt defect edges in the coronal position, which had bony pustute connection with gel materials. Density at the defect region significantly increased. 3D reconstruction suggested that defects became small. After hematoxylin-eosin staining, abundant fibrous connective tissue appeared in defect regions, with bony tissues. Mallory trichrism staining revealed that maroon mature bone tissues were found, surrounded by light blue chondroid tissues.

修复后8周，冠状位CT显示缺损边缘圆钝，与凝胶材料有骨性突起连接，缺损处密度增高明显，三维重建显示缺损范围较之前有所减小；标本苏木精-伊红染色后缺损部可见大量含血管成分的纤维结缔组织，有骨样组织结构形成，Mallory三色染色显示有褐红色成熟骨组织形成，其旁边有淡蓝色软骨样组织。

Mallory trichrism staining exhibited light blue samples. Eight weeks following repair, CT showed round blunt defect edges in the coronal position, which had bony pustute connection with gel materials. Density at the defect region significantly increased. 3D reconstruction suggested that defects became small. After hematoxylin-eosin staining, abundant fibrous connective tissue appeared in defect regions, with bony tissues. Mallory trichrism staining revealed that maroon mature bone tissues were found, surrounded by light blue chondroid tissues. Twelve weeks following repair, coronal defect regions were filled with callus. 3D reconstruction showed that defects were repaired. Defect region and surrounding bony tissues had bony connection, with thick bone trabecula and mature Haversian system.

修复后8周，冠状位CT显示缺损边缘圆钝，与凝胶材料有骨性突起连接，缺损处密度增高明显，三维重建显示缺损范围较之前有所减小；标本苏木精－伊红染色后缺损部可见大量含血管成分的纤维结缔组织，有骨样组织结构形成，Mallory三色染色显示有褐红色成熟骨组织形成，其旁边有淡蓝色软骨样组织修复后12周，冠状位CT显示缺损区基本被骨痂填满，三维重建示缺损基本修复；缺损区域和周围骨组织形成骨性结合，骨小梁粗大，哈弗氏系统成熟。

BACKGROUND: Chondrocytes in vitro cultured with traditional culture methods tend to dedifferentiate into fibroblasts through long-term serial subcultivation, which results in a terrible decrease in the number and activity of cells.

背景：传统培养方法体外培养的软骨细胞经长时间传代培养后往往去分化为成纤维细胞，导致细胞数量及活性下降。

OBJECTIVE: To construct discitis animal model by destroying the fibrous ring and the cartilage lamina through the surgery, in addition, to explore the changes of autoimmune reaction.

目的：通过手术破坏纤维环和软骨终板建立椎间盘炎的动物模型，探讨自免疫状态表达变化过程。

The pulmonary hamartoma is seen microscopically to be composed mostly of benign cartilage on the right that is jumbled with a fibrovascular stroma and scattered bronchial glands on the left.

图示的是显微镜下肺错构瘤的形态学变化，在图右侧可见大部分良性软骨组织，左侧可见纤维血管基质和支气管腺体混杂在一起。

Results: The degenerative changes were demonstrated in the knee joints injected with papain and L-cysteine, such as the lower activity scope of knee joint, thinner and worse articular cartilage, fissuration, fibrous degeneration, fibrillation and destroyed cartilage matrix.

结果：实验侧关节注射木瓜蛋白酶后，活动范围明显低于对照侧，关节软骨变薄且有裂隙形成、纤维变性、基质分解破坏等退行性改变，并随观察时间的延长而进一步发展。

The stem cells may be induced to express at least one characteristic of human intervertebral disc cells, such as fibroblast cells, chondrocyte cells, or notochordal cells, by exposing them to agents and/or environments calculated to induce the desired differentiation.

可通过干细胞暴露于诱导所需分化的试剂和/或环境来诱导它们表达至少一种人椎间盘细胞，如成纤维细胞、软骨细胞或背索细胞的特征。

Fig 1 At the experimental side, two weeks after operation (HE ×100) Many pieces of cartilage cells and spindle-shaped mesenchymal cells were found, by light microscope Fig 2 At the experimental side, twelve weeks after operation (HE ×100) Medullary cavity had formed, which contained hemoblasts and adipocytes, but the trabculae was not typical, by light microscope Fig 3 At the experimental side, twenty-four weeks after operation (HE ×100) The typical cancellous bone had formed, by light microscope Fig 4 At the control side, twenty-four weeks after operation (HE ×100) A large part of CXB was degraded, resorbed and replaced by fibrous tissue, but there was'not any new formed bone, by light mocroscope

图1 实验侧术后2周(HE ×100)镜下可见很多软骨细胞条索和团块生成及大量梭形间充质细胞图2 实验侧术后12周(HE ×100)镜下可见有髓腔形成，内含有造血和脂肪细胞，骨小梁尚不典型图3 实验侧术后24周(HE ×100)镜下可见形成典型的松质骨结构图4 对照侧术后24周(HE ×100)镜下可见大部分CXB被降解吸收，为纤维组织替代，无新骨形成

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失