纤维细胞的

To solve the problem and improve the safety of gene therapy, we used microencapsule, a insulation tool of cell transplantation immunity, to encapsule human fibroblastlike bone marrow stroma cells transfected by part of CEA gene and produced microencapsulated CEA transgeneic cell vaccines; we also studied the expression of vaccine in mouse body as well as its immunologic characteristics.

为解决上述问题、提高基因治疗的安全性，本研究采用细胞移植免疫用隔离工具-微胶囊包裹转染部分CEA基因的人成纤维样骨髓基质细胞HFCL，制备出CEA微囊化转基因细胞疫苗，并进行了疫苗在小鼠体内的表达及其免疫学性质的研究，探讨该疫苗应用于CEA阳性肿瘤治疗的可能性，并为进一步的临床应用研究奠定了基础。

BACKGROUND: One of the key neuropathological changes in Alzheimer disease is that neurofibrils over phosphorylated cytoskeletal protein composed of entwist together, and the phosphorylation of τ protein can be catalyzed by cyclin dependent kinase 5 (CDK5),however whether the phosphorylation of neurofilaments can be catalyzed by CDK5, as well as its role in the pathogenesis of Alzheimer diseases is less acknowledged.

背景：阿尔茨海默病的主要神经病理学特征之一是由过度磷酸化的细胞骨架蛋白如(o，神经细丝组成的神经原纤维缠结，细胞周期蛋白依赖性蛋白激酶5可催化蛋白的磷酸化，但神经细丝是否可被细胞周期蛋白依赖性蛋白激酶5磷酸化及其在阿尔茨海默病发病中的作用却知之甚少。

RESULTS: Cells in neurospheres expressed nestin and differentiated into neuro-specific enolase and glial fibrillary acidic protein.

结果：培养的神经球细胞表达巢蛋白，可分化为神经元特异性烯醇化酶、胶质纤维酸性蛋白阳性细胞。

At 5 days, immunocytochemical staining demonstrated positive reactions for glial fibrillary acidic protein and neuron specific enolase.

神经干细胞球诱导5 d，免疫细胞化学染色后可见胶质纤维酸性蛋白及神经元特异性烯醇酶呈阳性表达的细胞。

Objective To study the role of fibroblastic stromal cells in aseptic loosening.

目的 研究成纤维母细胞样基质细胞在人工关节置换术后无菌性松动中的作用。

4Histological examination of the capsular bags: It could be seen in group 4 that a small amount of LECs at the capsular equator proliferated and migrated to the posterior capsule, forming a thin soemmering ring in the periphery of the capsular bags, forming thin fibromembrane which embodied monolay metaplastic fibroblast-like cells in the center of the capsular bags, or with no cells or cortical material in the center of the capsular bags.

囊袋组织学检查：HSV-TK+GCV组可见少量赤道部晶状体上皮细胞(lens epithelial cells， LECs)增殖并向后囊膜迁移，在囊袋外周部形成稀薄的soemmering环，在中央部无细胞和皮质，或仅形成单细胞层纤维膜。

Methods: Inflammatory cells infiltration , synodal cells and fibroplastic proliferation were measured.

光镜下对佐剂性关节炎大鼠滑膜炎性细胞浸润、滑膜细胞、滑膜纤维组织增生评分，观察其组织形态学的改变。

Fibroplastic proliferation was observed at 14th days and later.

肝脏碘油栓塞HIFU损伤后即刻损伤组织表现为肝细胞结构破坏，肝细胞核固缩。3天后坏死区与正常组织分界清楚，坏死区细胞完全破坏。14天出现明显增生的纤维结缔组织，包绕坏死组织。

Results Microscopically, the tumor cells were epithelioid or short spindled and special nests of tumor cells separated by arboring fibrovascular septa. Such morphological variants of CCSK as myxoid degeneration, microcysts formation and sclerosing pattern of extracellular hyalined collagen simulating osteoid were present in some regions.

结果 镜下见瘤细胞为上皮样或短梭形，被分枝状纤维血管间质分隔成巢团状，部分区域见黏液样变性微囊肿和细胞外胶原玻璃样变类似骨样组织的硬化型等形态变异。

But in day 14th and day 28th groups, the ratio of macrophagus positive area in lung interstitium was bigger than that of control group（ P 〈0.05 ）, with collagen fibers depositing in the lung interstitium gradually.

结论博莱霉素鼠肺毛细血管内皮细胞间紧密连接持续开放，与巨噬细胞在组织间浸润密切相关，并可能是博莱霉素致肺纤维化发生的重要因素。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。