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Results: The staining of VG, HE show that the subepidermal thickness were reduced , the arrange of collagen tended to uni...

结果:兔耳腹侧面增生性瘢痕局部注射苦参碱后,按时间段取材;VG和HE染色显示真皮层明显变薄,成纤维细胞数量明显减少,胶原排列趋于一致;12周后,对照组苦参碱组的增生指数、成纤维细胞数密度、胶原密度分别为3.25±0.89/2.15±0.12,4517.5±879.6/3551.2±234.1,39.89±14.12/28.75±10.87。

Tumor cells grew actively in the tumor tissues of the control group. Prodrug therapy group: small amount of tumor cells were denatured vacuously,others were infiltrated by lympholeukocyte,and the growth of tumor cells were surspressed.Prodrug themochemotherapy group: what we can see that tumor cells were denatured vacuously, mesoplasts crinkled, cellular boundary disappered, only a small number of tumor cells remained, fibroblast were seen scatteredly, tumor cells were invaded by a lot of lympholeukocyte and eosinophilic granulocyte. Normal liver tissues, stomach tissues, lung tissues, pancreas tissues, small intestine tissues, large intestine tissues showed normal shape.

对照组肿瘤组织见肿瘤细胞生长活跃;前药治疗组肿瘤组织见有少量细胞空泡变性,少量淋巴细胞浸润,肿瘤细胞生长受到抑制;前药热疗组肿瘤组织可见肿瘤细胞空泡变性,细胞核皱缩,边集甚至消失,仅残留少量肿瘤细胞,并可见散在的成纤维细胞,大量淋巴细胞和嗜酸性粒细胞浸润;3组裸鼠正常肝组织、胃、肺、胰腺、小肠、大肠组织均呈正常形态学,无病理性损伤改变。

Objective To investigate the expression and significance of basophilic fibroblast growth factor during hepatocarcinigenesis in the rats.

目的 探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)在肝癌发生过程中的表达及意义方法采用免疫组织化学ABC法对二乙基亚硝胺诱发大鼠肝癌发生过程中碱性成纤维细胞生长因子表达情况进行观察。

We hypothesized that MCP-1 may mediate fibrotic remodeling through recruitment of mononuclear cells and direct effects on fibroblasts.

我们由此推测MCP-1可能通过单核细胞的趋化作用以及直接作用于纤维母细胞来介导纤维化心肌重塑。

3There were fusiform cells on the surface of the matrix by SEM, and the cells tightly attach into the membrane.

3扫描电镜下可见PEG/PBU膜表面有梭形的成纤维细胞出现,且成纤维细胞紧密贴附于PEG/PBT膜上。

Histopathologic specimen (hematoxylineosin, original magnification x20) shows cellular Antoni A fibers with nuclear palisading and less cellular Antoni B fibers.

组织病理学标本(HE染色,×20)显示Antoni A纤维细胞,细胞核呈栅栏状,并见少量的Antoni B纤维细胞。

To observe the influence of hirudin on the cultured sclera flbroblast and extracellular matrix, and research the mechanism of hirudin treating the diseases caused by the proliferous fibroblast.

实验目的通过观察水蛭素对体外培养的巩膜成纤维细胞及细胞外基质的影响,从而探讨水蛭素防治由成纤维细胞增生引起的疾病的机制。

Fig 4 Few of rough endoplasmic reticula, mitochondrid and co llagen can be seen in the cytoplasm of fibroblast, the ribosome of rER is degran ulated, the nucleous is abnormal, there are a lot of granule (maybe the antisens e oligodeoxynucleotide) in the cytoplasm TEM×5200

图4反义核酸组的瘢痕成纤维细胞粗面内质网较少、有脱颗粒现象,线粒体少,胞核畸形,胞内有吞噬颗粒,细胞周围胶原纤维较少TEM×5200

MATERIALS: Basic fibroblast growth factor freeze-dry powder (50 mg/ampoule) was thoroughly dissolved with ddH2O to prepare 5 g/L bFGF solution.

材料:取碱性成纤维细胞生长因子冻干粉(50 mg/支),ddH20彻底溶解,制成含碱性成纤维细胞生长因子 5 g/L的溶液。

BACKGROUND: Lung fibroblasts are believed to play an important role in lung tissue repair and regenerative process.

背景:肺成纤维母细胞在肺组织修复和再生过程中起重要作用,但肺成纤维母细胞的分化特性尚未完全阐明。

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