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纤维细胞

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GHK is a tripeptide found in normal human plasma. It was found to accelerate growth in cultured cells and tissues e.g. fibroblasts, macrophages.

GHK是存在于人类血浆中的一种三肽,研究表明它能促进纤维原细胞,巨噬细胞等多种细胞及组织的生长。

The findings of the newly identified goose paramyxovirus strain GPMV/HBexperimental infection were as follows: The challenge caused high morbidity and highmortality.The clinical signs included severe depression, decreased appetite or anorexia,white,yellow and green diarrhea, with neural symptoms;pathological changes showed thathaemorrhage and ulceration of intestine mucosa, necrosis of spleen and pancreas,andedema of liver and kidney, uratic deposition in kidney.Eosinophilic inclusion bodies werefound in the cytoplasm of pancreas and a large quantities of fiber protein were found inintestine. Lots of hemosidefin was found in some area of liver and kidney. A number ofT、B lymphocytes reduced sharply in spleen,lymph nodes in dead geese. Transmissionalelectron microscope showed that some cells had the morphological characteristics ofmitochondria swelling, morphological changes were condensation of nuclear chromatininto dense masses,followed by its marginating against the nuclear envelope, andespecially concentration of cytoplasm association with lots of lipid droplet.

人工感染雏鹅实验中,雏鹅临床表现为高发病率和高死亡率,食欲和饮水减少,拉白色、黄绿色稀粪,伴有神经症状;常规组织学观察,脾脏和胰腺肿大,有白色坏死斑点,肠道出血和坏死,肝脏肿大变性,肾脏肿大变性有尿酸盐沉着等;用特殊染色和组织化学方法首次对人工感染鹅副粘病毒的雏鹅的重要脏器进行研究,结果表明:胰腺中发现病毒包涵体,肠道中大量纤维素以及胶原纤维增生,肾脏、肺脏大量含铁血黄素沉着,免疫器官如脾脏和淋巴结中T、B淋巴细胞大量减少;电镜下多种细胞呈现线粒体水肿,多种实质细胞的染色质固缩,染色质边集,特别是细胞内容物如脂肪滴增多的病理变化特征。

(1) Oxidative/antioxidative reactions, inflammatory reactions, apoptosis in lung are involved in the pathogenesis of HILI;(2) ABX, rHuEPO have protective effects on HILI respectively;(3) Hyperoxia can increase VILI in rats, but has little effects with low tidal volume mechanical ventilation.

结论(1)氧化抗氧化失衡,炎症反应,肺内细胞凋亡参与了高氧所致成年大鼠肺损伤的过程;(2)ABX通过抗炎、抗氧化、抑制细胞凋亡作用对成年大鼠高氧肺损伤具有保护作用;rHuEPO通过抗炎、抗氧化、抑制细胞凋亡及一定程度的抗纤维化作用对成年大鼠高氧肺损伤具有保护作用;(3)高浓度氧能明显加重大鼠通气机所致肺损伤,而高浓度氧对小潮气量通气影响较小。

Results: Compared with control dogs, sections from AF dogs showed cellular hypertrophy, disarranged cell bundles and increasing connective tissue.

结果:与对照犬相比,AF犬肺静脉肌袖内心肌细胞增大、排列紊乱;细胞核大小不甚规则,核异型性明显,细胞内可见肌纤维断裂;心肌纤维之间连接组织积聚,使心肌细胞之间的间隔增宽。

The cells aggregated to form a cell mass and invaginated as a cell mass into the ECM. The cells also extended fine fibrillar processes into the ECM.

细胞聚集形成细胞团并内陷至ECM中,这些细胞产生的纤维状细长突起延伸至ECM中。

Fig 1 At the experimental side, two weeks after operation (HE ×100) Many pieces of cartilage cells and spindle-shaped mesenchymal cells were found, by light microscope Fig 2 At the experimental side, twelve weeks after operation (HE ×100) Medullary cavity had formed, which contained hemoblasts and adipocytes, but the trabculae was not typical, by light microscope Fig 3 At the experimental side, twenty-four weeks after operation (HE ×100) The typical cancellous bone had formed, by light microscope Fig 4 At the control side, twenty-four weeks after operation (HE ×100) A large part of CXB was degraded, resorbed and replaced by fibrous tissue, but there was'not any new formed bone, by light mocroscope

图1 实验侧术后2周(HE ×100)镜下可见很多软骨细胞条索和团块生成及大量梭形间充质细胞图2 实验侧术后12周(HE ×100)镜下可见有髓腔形成,内含有造血和脂肪细胞,骨小梁尚不典型图3 实验侧术后24周(HE ×100)镜下可见形成典型的松质骨结构图4 对照侧术后24周(HE ×100)镜下可见大部分CXB被降解吸收,为纤维组织替代,无新骨形成

Pathologic examination included: tubulointerstitial lesion which was the main pathologic presentation, tubular epithelial cell becoming flat, TEC necrosis and wither, departure between the cytoplasm and basis membrane, drops of protein in cytoplasm, broken basic membrane of TEC, inflammatory cells infiltrating in tubulointerstitium, tubulointerstitium fibrosis, plasm cell infiltration.

MM肾损害主要以小管-间质病变为主,病理表现为肾小管上皮细胞扁平,存在不同程度变性、坏死或萎缩,胞浆与基膜分离,胞浆内可见蛋白滴,甚至小管基膜断裂,间质炎性细胞浸润、纤维化,部分有淀粉样物质沉积,较少见浆细胞浸润。

Visible-light absorbance spectrum showed,there were Guaiacyl lignin and Syringyl lignin in cell wall of fiber,ground tissue parenchyma cell and vessel.

木质素在纤维、基本薄壁组织细胞、导管分子和石细胞的细胞壁上均有沉积,但沉积先后和周期不同。

Results: The animal experimental model indicates the facial nerve' s bone canal fracture can make the facial nerve hyperaemia, strut, and putrescence, denaturalization and with the Schwann cell and the cell become more and more, taking on the restore evidence.

结果 动物实验表明:面神经骨管骨折后,面神经发生充血肿胀,并出现脱髓鞘、变性及坏死的变化,伴随神经损伤的同时出现巨噬细胞和施万细胞增生肥大及纤维母细胞的增生,呈现修复迹象。

Micro-tube lysosome with ACPase positive was firstly found since 1973, this kind of structure was observed in many cells, and called line lysosome, these two kinds of lysosome were regarded as manifestation pattern in different period, and was round when it was in relative silence, and line when activating state.

微管是细胞骨架中最粗的一种纤维丝,在活细胞内微管是一种动态的结构,在一定条件下可聚合或解聚,因此细胞内呈现了各种形态的排列方式,以适应变动的细胞质和完成它们各自的功能。

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