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纤维组织形成

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Results: Current of 1 mA, 210 s could cause necrosis and cavitation in the dorsal funiculus, resulting in bilateral corticospinal tract injury; rats with electrolytic lesions exhibited declined motor function with decreased Tarlov score, increased Ashworth score and reduced inclined plane angle, the HRP labeled neuron counts in motor cortex were also significantly lower in the lesioned group than sham-operation group.

结果:1 mA, 210 s的损伤电流,可在脊髓后索造成神经组织坏死,形成空腔,使双侧皮质脊髓束纤维受损;术后1周、2周、3周观察,电损毁组大鼠运动功能显著低于假手术组,表现为后肢运动评分下降,Ashworth 肌张力评分增大,斜板实验角度下降;电损毁组运动皮质标记神经元计数也显著低于假手术组。

Under transmission electron microscope, cellular swelling in brain tissue, nuclear membrane of neuron has incisures, some chromatic agglutination, group A mainly appears endoplasmic reticulum distention and glial cell endocytosis, while group B mainly appears histolysis; cardiac fibrous structure is chaotic, Z line concentrates, mitochondria swelling, nucleus deform; the ecphyma of podocyte becomes thinner and longer like villus, some mix together, plasma membrane infolding of renal cells decreases, mitochondria malformation, cells in lumens.

透射电镜观察显示,试验组动物脑组织细胞肿胀,神经元核膜出现切迹,部分染色质凝集,A组动物出现内质网扩张及胶质细胞吞噬现象,B组动物以组织溶解为主;心肌纤维结构紊乱,Z线聚集,收缩带形成,线粒体肿胀,核变形;肾小球足突细长,绒毛化,并可见足突融合,肾小管上皮细胞质膜内褶减少,线粒体畸形,管腔可见脱落细胞,上述改变均以B组为著。

In treatment group, there was no progressive necrosis in stasis zone, and at 24 h post injury, capillary dilation, cell edema and inflammatory infiltration were lessened significantly. In control group, 2 wounds had progressive necrosis (accounted for 10% of the total). Cell edema, inflammatory infiltration and capillary thrombosis were serious, Until 72 hr post injury, cell edema did not subside and necrosis of the dermis worsened. 2. Pathological assessment of the stasis zone tissue: As compared with that in control group, in treatment group the dermis structure in stasis zone was intact and the collagenous fiber bundle was normal.

结果:①创面细胞形态学改变:伤后8h毛细血管扩张、细胞水肿,炎性浸润最明显;治疗组中央淤滞区无进行性坏死,伤后24h后毛细血管扩张、细胞水肿、炎性浸润减轻;对照组2个创面呈进行性坏死(占10%),中央淤滞区细胞水肿、炎性浸润明显,毛细血管血栓形成,伤后72h水肿仍明显,真皮坏死加重;②淤滞区组织病理学评分:治疗组与对照组相比,治疗侧淤滞区的表皮结构相对完整、胶原纤维束相对正常,粒细胞浸润小于5个/400倍视野。

The cooperation of 8-MOP/UVA could induced dermis of the non- lesion back skin of vulgar psoriatic patients and the cultured dermic fibroblasts produced large aging-associated mutations of mtDNA rapidly, it is feasible to establish human models in vivo and in vitro which could produced large aging-assoiated mutations of mtDNA rapidly for studies of the mechanisms of mutations of mtDNA in skin photoaging.

2.8-MOP/UVA可诱导寻常型银屑病患者背部非皮损区真皮组织及培养的成纤维细胞迅速产生光老化相关的mtDNA突变,建立迅速产生光老化相关mtDNA突变的体内外模型,利用该模型进一步研究mtDNA突变在光老化皮肤中的产生机制及其在皮肤光老化形成中的作用是可行的。

Wounds such as road accidents, gunshot injuries, fire burns and some internal medicine diseases like diabetes, tumors and palsies always accompany with muscle injuries. Muscle regeneration is relatively difficult on the conditions of serious and large area of muscle injury or loss. Finally the raw surface will be replaced by fibrous connective tissue and form scar, which may disenable the movement of body and badly influence nerves and blood-vascular system, and eventually develop into obduracy wound.

各种创伤如车祸伤、枪弹伤、烧伤及部份内科疾病如糖尿病、肿瘤和瘫痪所致的肢体坏疽都常伴肌组织损伤,对于严重或面积较大的肌损伤或缺损,肌肉的再生相对困难,创面最终被纤维结缔组织替代而形成瘢痕,导致机体运动功能障碍并累及神经、血管系统,影响患者的预后和生活质量。

The fronds of tissue have thin fibrovascular cores. The fronds have an overal papillary pattern.

图示可见以较细的纤维血管成分为中心形成许多乳头状的叶状组织。

The nuclei were oval, round without alypia, and rate of mitotic activity was evident1 Psudopapillary structure with a fibrovascular core was remarkable Hemorrhage, foam cells and cholesterol crystals were often found.

肿瘤细胞围绕纤维血管覆层排列形成假乳头突起,常见肿瘤细胞的退变、出血、泡沫细胞和胆固醇裂隙。1例见肝脏内肿瘤组织转移。

Swyer-James syndrome is considered to be a post-infectious form of bronchiolitis obliterans, pathologically defined by the presence of submucosal and peribronchiolar fibrosis with destruction and obliterative scarring of the small airways.

Swyer-James综合征被认为是闭塞性细支气管炎感染后形成的,病理表现为出现黏膜下及支气管周围纤维化并有小气道破坏和疤痕组织,SJS是一类有不同临床表现的综合征,这些表现主要与囊状支气管扩张是否出现有关。

Methods Male Sprague Dawley rats were induced by ligating the anterior descending coronary artery and were divided into the 2nd, 4th, 8th, 12th and 21st week groups. Elastic fibers were evaluated in the infarct region using Masson trichrome staining, Uana orcein staining and image analysis. The expressions of TNFα and IL-1β were also detected by immunohistochemistry.

SD大鼠冠状动脉前降支结扎形成心肌梗死模型,于术后2、4、8、12、21周时,用Masson染色、Uana地衣红染色技术和免疫组织化学方法,分别观察梗死区弹性纤维和白细胞介素1β(IL-1β)、肿瘤坏死因子的变化,计算机图像分析系统作半定量分析。

Methods N-vinyl pyrrolidone, the hydrophilic monomer, was grafted onto the surface of silicone breast implants by 60Co radiation.The implants were buried in the bilateral subcutaneous layers of the back of rabbits.The unchanged implants were used as the control group.

利用钴60共辐射的方法把亲水性单体 N-乙烯基吡咯烷酮接枝到硅胶乳房假体表面,改变其表面特性后植入兔的背部,以未经改性的正常假体作为对照组,隔一定时间通过组织切片及CT扫描的方法观察假体周围纤维囊壁的形成情况。

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