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纤维原细胞

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Rat in Group B was set an air bladder which was empty and not perfused water. Water of 0.6 ml, 0.8 ml, 1.0 ml, 1.2 ml, 1.4 ml and 1.5 ml was perfused respectively into the air bladders which were set in the colon of rats in group C, D, E, F, G and H. Then the changes of ethology of the rats were recorded in interval of an hour.

应用疼痛行为学的观察方法,观察1h各组动物的行为学改变,并采用免疫荧光化学的方法,观察大鼠DCN中神经元被激活的标志c-fos及胶质细胞的胶质原纤维酸性蛋白(glial fibrillary acidic protein, GFAP)和小胶质细胞特异性补体OX42的表达情况,空白对照组是在疼痛高峰点(1.2 ml)处死取材。

In the pathological proceeding of pulmonary fibrosis, myofibroblast plays an important role, such as: the abnormal extracellular matrix deposition causing by the remarkable capability of collagen synthesis, derogation of the lung compliance owning to the contractibility of myofibroblast,secreting many cytokines,which contribute to the damage of the alveolar epithelial cells.

肌成纤维细胞在PF的病理进程中扮演着重要的角色,其胶原合成能力强可造成细胞外基质的异常沉积、具收缩性使肺顺应性下降、分泌多种炎性介质加重肺泡上皮损伤。

Research of ultramicro- structure of anal sphincter in the cases of patients with fecal incontinence shows : shortness of smooth muscle cells of anal sphincter , destruction of normal structure of the rest cells , elongation of elastic tissue and increase of collagen fibers. Thus the most familiar cause of copracrasia is Degeneration of finespun smooth muscle of anal sphincter which mantain anal sphincter closed .One of the pathomechanism of fecal incontinence is decrease of anal resting pressure .

对大便失禁者肛门内括约肌的超微结构研究发现:肛门内括约肌的平滑肌细胞缺失、剩余细胞的正常关系破坏、弹性组织拉伸、胶原纤维成分增加,因而大便溢漏最常见的原因是维持括约肌关闭的肌肉-肛门内括约肌的纤细平滑肌的退行性病变,肛管静息压降低是大便失禁发病的一个病理学机制。

Astragali many candies can be promoted into hyperplasia and collagenic formation of fibrous cells within the range of certain density, the ones that strengthened the wound ground substance are synthetic in order to promote the wound to heal.

细胞实验结果显示:黄芪多糖在一定的浓度范围内可促进成纤维细胞的增殖和胶原的合成,增强创伤基质的合成以促进伤口愈合。

Results Compared to those before treatment the volume of the implanted keloid of Group D began to decrease since 14 days after treatment time-dependently (all P 《 0.05), and the volumes of the other 3 groups continued to increase and peaked on days 21, 14, or 7 respectively (all P 《 0.05).Microscopy showed infiltration of a larger quantity of histiocyte in the keloid tissue, and more obvious collagen disorganization and apoptosis of fibroblasts in Group D than in the other 3 groups.The protein expression of Bcl-2 was more remarkable and the protein expression of BAX was less remarkable in Group D than iu the other 3 groups.

结果 用药前和用药后7、14、21、28、35 d,D组瘢痕疙瘩组织块体积(mm3)分别为173±5、172±5、147±5、125±6、112±7和84±9,从用药后14 d开始明显缩小(均P<0.05);而其他3组瘢痕疙瘩组织块体积均明显增大,从用约后7 d开始各时点测得的体积均明显大于D组(均P<0.05)。D组瘢痕疙瘩组织中有大量小鼠组织细胞浸润,胶原结构破坏和成纤维细胞凋亡明显重于其他3组,Bcl-2蛋门质表达明显弱于而Bax蛋白质表达明显强于其他3组。

The gene regulating sequence of human collagen type Ⅰ is located at 5'end and first intron. The carriers of reporting gene was made, and the function of promoter, enhancer and inhibiter was examined in this study. On the basis of above work, MBP ectopic expression carriers were further built. The result laid a foundation for investigating the feasibility, and validity to specially express MBP gene of human nervous system, in tendon fibroblast.

人Ⅰ型胶原基因调节序列位于5'端和第一内含子,本研究构建了带报告基因的载体并检测了其启动子,增强子和减弱子的功能,以此为基础,进一步构建了MBP异位表达载体,为探索在神经系统少突胶质细胞特异表达的人脑髓鞘碱性蛋白MBP基因转至肌腱成纤维细胞表达的可行性和有效性奠定了基础。

Methods: The basic fibroblast growth factor-based need to establish normal mitogen epidermal melanocyte cell culture, MTT method aloesin on black ...

利用碱性成纤维细胞生长因子为主要有丝分裂原建立正常人表皮黑素细胞培养系,MTT法测定芦荟苦素对黑。。。

Results In the subendocardium of the left ventricle,apical part and interventricular septum,the pathologic changes of degeneration and necrosis were found out in some bigger size of point or rope type separately,in which the filtration of lymphocyte and mononuclear cells were seen in great quantities.The myocardial cells presented granular denaturation and myofibril lysis.

结果 实验组大鼠心肌在左室壁内膜下、心尖、室中隔部位出现明显坏死等改变,病变呈灶状或条索状分布,涉及范围较大,有淋巴细胞和单核细胞浸润,心肌细胞呈颗粒变性,肌原纤维凝聚、崩解,部分肌纤维溶解。

In carcinomatous mucosa, immunoreaction of the carinomatous cell nest was negative, or only remnants of positively were seen at the site of the former membrane by collagen type Ⅳ.

结果 正常组织的基底膜呈现很强的Ⅳ型胶原抗体阳性反应,在基底膜形成较粗的环形染色带;Ⅲ型胶原抗体阳性反应在细胞外间质呈连续的细丝纤维样。

The result demonstrates that the capillaries and fibrils in dermis of PSS have marked changes, but less marked in that of LS.

结果表明,真皮层毛细血管的内皮细胞、基底膜和胶原原纤维及其周围的基质均发生明显的变化。

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