纤维化的

The influence of the fibration of iron during the cold deep drawing on the mechnical properities of the composite was studied.

摘 要：采用液固两相铸造复合工艺制备了铁纤维增强铜基复合材料，研究了深度变形过程中铁组元纤维化对复合材料性能的影响。

Affect of kwoninone on fibroblastic proliferation, morphology and expression of TGF-β1 ［ABSTRACT］ AIM:To study

苦参素可通过抑制成纤维细胞增殖及TGF-β1的表达而起到抗肝纤维化作用。

Theurinary IL-6 level positively correlated with density of glomerular matrix membrane, global sclerosis, fiber or fibrocellular crescents and interstitial fibrosis (p. 05). According to the degree of density of glomerular matrix membrane and interstitial fibrosis, urinary Col-IV level had better correlation than urinary TGF-betal and IL-6 levels.In IgAN, Col-IV showed increased expression in diseased renal tissue whereas the site of expression of TGF-betal was mainly localized within the cytoplasm of tubular epithelial cells. Interstial expressionwas also present but glomerular TGF-betal expression was found only in patients with heavy mesangial proliferation. There was a significant correlation between glomerular positivity for Col-IV and severity of histological damage. There was also a significant correlation between positivity for TGF-betal and Col-IV in the tubular epithelial and interstitial lesions. In contrast, there was no ralationship between glomerular positivity for TGF-betal and severity of histological damage.The urinary TGF-betal level paralleled tubular TGF-betal expression.

结果 ①IgAN患者尿TGF-β1、IL-6、Col-Ⅳ水平较健康人明显增高(P＜0.01)，该变化与血中的浓度无关(P＞0.05)；②尿TGF-β1水平与小管间质TGF-β1阳性表达呈正相关(P=0.000)，而与小球TGF-β1阳性表达无关(P＞0.05)，尿Col-Ⅳ水平与小球和小管间质Col-Ⅳ阳性表达均呈良好的相关性(P＜0.01)，还与小管间质TGF-β1阳性表达呈正相关(P＜0.05)：③小球Col-Ⅳ阳性表达与肾组织慢性病变密切相关(P＜0.05)，小管间质Col-Ⅳ和TGF-β1阳性表达均与肾小管间质病变呈良好的相关性(P＜0.01)，而小球TGF-β1阳性表达与肾组织损伤无关(P＞0.05)；④尿TGF-β1、Col-Ⅳ水平与肾小球基质基底膜面密度、小管间质病变呈正相关(P＜0.01)，与小球内细胞数呈负相关(P＜0.05)，该结果与其在组织中的表达一致；尿IL-6水平浙江大学硕士学位论文尿TGF一B一、IL一6和Col一IV在IgA肾病中的应用价值与基质基底膜面密度、球性硬化、纤维或细胞纤维新月体所占肾小球百分数及小管间质病变均有显著的相关性(F.05)；在轻度肾病理损伤时，尿'l'G卜pl、I卜6、Col一IV水平即升高，而尿Col一W在反映细胞外基质积聚和间质纤维化程度上比尿TGF一pl和IL一6有更好的相关性。

We hypothesized that MCP-1 may mediate fibrotic remodeling through recruitment of mononuclear cells and direct effects on fibroblasts.

我们由此推测MCP-1可能通过单核细胞的趋化作用以及直接作用于纤维母细胞来介导纤维化心肌重塑。

Objective: To explore the effect and happening mechanism of hdrochloric acid kukoline for the treatment of renal interstitial fibrosis,to supply some according for clinic how to resist glomeruli and nephric tubule interstitial fibrosis.

目的：探讨盐酸青藤碱在治疗肾间质性纤维化中的作用及其发生机制，为临床如何阻止、防止肾小球和肾小管间质纤维硬化提供借鉴。

Consistent findings in lung biopsies of AP patients included endothelialitis of pulmonary vessels, active fibrosis, lymphangitic inflammatory infiltrates rich in plasma cells and histiocytes with or without nodule formation, and fibrinous pleuritis.

这6例肺穿的其他共同特征包括肺血管内皮炎、纤维化、淋巴管炎细胞浸润（其内富于浆细胞和组织细胞，伴或不伴淋巴滤泡形成）、纤维素性胸膜炎。

RESULTS: The extract of Aml could reduce the abnormally high levels of ALT and AST. Examined by light microscope , the degeneration and necrosis level of hepatocytes and the distribution of collagen fibrosis were markedly increased in the model group. The pathological changes and the c ollagen fibrosis associated with hepatic fibrosis decreased significantly in the prophylactically treated groups.

结果： 蓍草提取物预防给药能降低 CCl 4所致大鼠血清中异常增高的 ALT 、 AST 含量，光镜下观察肝纤维化模型组大鼠肝细胞严重变性、坏死，胶原纤维明显增加，蓍草预防各组大鼠肝细胞病理损伤得到明显改善。

Sixty six male Sprague-Dawley rats were randomly divided into control group,and 5 model hepatic fibrosis groups perfused alcoholic,maize oil and pyrazole for 2 weeks,4 weeks,8 weeks, 12 weeks and 16 weeks (11 rats in each group) respect...

结果 与对照组比较，酒精灌胃 4周、8周、12周、16周组大鼠OPN、α SMA表达显著增强并且肝内胶原纤维含量显著增加。正常肝组织中几乎不表达OPN ，在酒精性肝纤维化大鼠模型的建立过程中，从第四周开始中央静脉。。。

RESULTS: The kwoninone has an could significantly inhibit fibro

苦参素可通过抑制成纤维细胞增殖及TGF-β1的表达而起到抗肝纤维化作用。

Over time, the fibers cause chronic inflammation, the development of pleural fibroses (a thickening of the pleural surfaces) and pleural effusions (buildup of fluid in the pleural spaces) and in many people, cancerous cell development.

随着时间的推移，这些纤维导致慢性炎症，使得胸膜纤维化和胸膜腔积液，并在大部分人中，癌细胞开始生长。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。