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Objective To investigate the effects of EGB on hepatic fibrosis and expression of Activin A in rats with fibrosis.

目的研究银杏叶提取物对肝纤维化大鼠Activin A表达的影响及抗纤维化作用。

The basic pathological change of silicosis is the lung interstitial fibrosis and the formation of silicotic nodule.

与矽肺的发病相似,特发性肺纤维化也是以肺成纤维细胞大量增殖为主要特征的肺纤维化疾病。

E and Sirus red in supersaturated picric acid solution;the amount of HA in serum was measured with the method of radiative immunity;the quantitative expression of fibrosis factor—TGF、PDGF was measured with the method of immunity histochemistry.Results:Myocardial collagen in model group increased obviously compared with normal group from the results of electron microscope、H.E、Sirus red in supersaturated picric acid solution.

腹腔注射柯萨奇B3病毒建立病毒性心肌炎慢性期心肌纤维化小鼠模型,随机分为模型对照组、通心络低剂量组、中剂量组、高剂量组,并设正常对照组,用药四周后处死动物通过透射电镜观察心肌细胞超微结构;HE染色、苦味酸天狼星红染色观察心肌胶原数量;放免法测定血清透明质酸的含量;免疫组化染色观察致纤维化细胞因子—转化生长因子和血小板衍生生长因子的定量表达。

Methods:Establish the model of myocardial fibrosis in chronic stage of viral myocarditis by injecting CVB3 into Balb/c rats,divide these rats into model group、Tong xin luo low dose group、Tong xin luo medium dose group、Tong xin luo high dose group and set up normal group,after four weeks of giving medicine execute the animals and observe the ultrastructure of myocardial cell with tramission electron microscope,the quantity of myocardial collagen was observed by staining with H.E and Sirus red in supersaturated picric acid solution;the amount of HA in serum was measured with the method of radiative immunity;the quantitative expression of fibrosis factor—TGF、PDGF was measured with the method of immunity histochemistry.

腹腔注射柯萨奇B3病毒建立病毒性心肌炎慢性期心肌纤维化小鼠模型,随机分为模型对照组、通心络低剂量组、中剂量组、高剂量组,并设正常对照组,用药四周后处死动物通过透射电镜观察心肌细胞超微结构;HE染色、苦味酸天狼星红染色观察心肌胶原数量;放免法测定血清透明质酸的含量;免疫组化染色观察致纤维化细胞因子—转化生长因子和血小板衍生生长因子的定量表达。

Based on the spinneret holes,spinning liquid, spinning technology ,it analyzed the influence of these factors to the fiber profiles,fiber performances and the use of profiled fiber.

文章从喷丝孔形状、纺丝液性质、纺丝工艺条件等方面分析了这些影响因素对纤维截面、纤维性能及纤维用途的影响,并以几种典型异形纤维为例阐述了不同截面纤维的用途,指出异形纤维是具有广阔前景的一种差别化纤维。

In this article, we used automotive immunohistochemical stainer to check the expressions of HBsAg and HCV antigens in 100 cases of HCC and their adjacent tissues, mean while, we checked their histological activity index and hepatic fibrosis degree. We also used radioimmunoassay to detect serum levels of 4 serum fibrosis markers and serum AFP levels in these cases. Immunofluorescence labeling and flow cytometry were used to check the T-cell subpopulations and the activity of NK cells of these 100 cases. Then the correlations among these factors were studied.

本文采用全自动免疫组化仪对100例肝癌组织及癌旁组织中的HBsAg、HCV抗原表达进行了标记,同时对其进行肝组织活动指数、纤维化分期;同时采用放射免疫测定方法检测同期血清透明质酸、Ⅲ型前胶原蛋白、层粘连蛋白和Ⅳ型胶原蛋白等四项血清肝纤维化标志物和血清甲胎蛋白水平;采用免疫荧光标记技术和流式细胞仪对T细胞亚群及NK细胞活性测定,对各项指标的相关性进行系列对比研究。

Bamboo first crystallizes then lignifies during bamboo shoot growth and basically forms crystal structure in one month. 1-year-old bamboo culm ends growth and its height,thickness, volume almost change little, but culm tissue is small and tender and there is more water and less substance in it. Bamboo crystal proportion keeps invariable during this period.2-year-old bamboo culm begin to lignify,its cellulose proportion debases and its crystal proportion decreases. Bamboo lignin debases, crystal proportion changes a little in the end of this period.Many-old-year bamboo culm crystal proportion is almost invariable. Freaky bamboo cell wall crystal region's thickness is less than normal bamboo's. Bamboo cross section crystal area and the ratio of long axis to short axis are less than normal bamboo's,and roundness,irregular index, the fiber cap density per unit area increase more than normal bamboo's.

竹笋生长阶段是先结晶后木素化的过程,一个月内细胞壁结晶组织基本形成;2)一年生竹材的植株秆茎生长结束,秆茎的高度、粗度和体积变化不大,但秆茎的组织幼嫩,含水量高,干物质少,竹材结晶度基本不变;3)二年生竹材的植株开始木质化,纤维素比例降低,结晶度减少,到后期竹子木质化降低,竹材结晶度变化不大;4)多年生竹材的结晶度没有太大的变化,结晶度大小处于波动状态;5)畸形竹材纤维帽细胞壁结晶区的厚度比正常竹小,其横截面结晶区的面积、纤维帽长轴与短轴比有所减少,而圆形度、异型指数有所加大,单位面积纤维帽的密度增大。

Fibrous hydrous zirconia, spinnable hydrous zirconia chelated by acetylacctone and modifiedhydrous zirconia were synthesized from zirconium oxychlorid(ZrOCl_2·8H_2O) and then applied toprepare ZrO_2/PVA electrospinning hybrid fibers, ZrO_2/PVA continuous hybrid fiber and ZrO_2/PVPhybrid microsphere respectively. The chemical structure, properties, microstructure and formationmechanism of the corresponding materials were investigated.

论文以无机盐ZrOCl_2·8H_2O为原料,合成出纤维状的ZrO_2水合物、乙酰丙酮配位的可纺性ZrO_2水合物和正丁醇改性的ZrO_2水合物,分别与PVA和PVP杂化复合,制备出ZrO_2/PVA杂化电纺纤维、ZrO_2/PVP杂化连续纤维和ZrO_2/PVP杂化微球,并对相关材料的组成、结构、性能及形成机理等进行了深入分析和研究。

Curcumine could improve experimental hepatic fibrosis and down-regulated the expression of leptin and leptin receptor in liver, which probably contributed to one of the mechanisms about anti-fibrosis.

姜黄素能明显改善实验性大鼠肝纤维化,同时下调肝纤维化大鼠肝脏中瘦素以及瘦素受体的水平,这可能是姜黄素抗肝纤维化作用的机制之一。

Make a copyof rat pulmonary fibrosis by infusing bleomycin through trachea , isolate and the pulmonary fibroblast, then interfered by atorvastatin ,divided into 3 groups of vacant ,TGF-β1 induced and atorvastatin interceped of different dosage , observe the structure of the cell by fiberscope ,the multiplication of the cell by MTT counting method, the expression of theα-SMA by immunity tissue chemistry staining method .

气管内注入博莱霉素(bleomycin,BLM)复制大鼠肺纤维化模型,并分离培养肺成纤维细胞,用阿托伐他汀对其进行干预,分为空白组、TGF-β1诱导组和不同剂量阿托伐他汀阻断组,用倒置纤维镜观察细胞的形态结构,MTT计数法观察各组细胞的增殖情况,免疫组化染色法定性观察α-平滑肌肌动蛋白(α-smooth muscleactin ,α-SMA)的表达情况。

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