纤维化

The basic pathological change of silicosis is the lung interstitial fibrosis and the formation of silicotic nodule.

与矽肺的发病相似，特发性肺纤维化也是以肺成纤维细胞大量增殖为主要特征的肺纤维化疾病。

E and Sirus red in supersaturated picric acid solution;the amount of HA in serum was measured with the method of radiative immunity;the quantitative expression of fibrosis factor—TGF、PDGF was measured with the method of immunity histochemistry.Results:Myocardial collagen in model group increased obviously compared with normal group from the results of electron microscope、H.E、Sirus red in supersaturated picric acid solution.

腹腔注射柯萨奇B3病毒建立病毒性心肌炎慢性期心肌纤维化小鼠模型，随机分为模型对照组、通心络低剂量组、中剂量组、高剂量组，并设正常对照组，用药四周后处死动物通过透射电镜观察心肌细胞超微结构；HE染色、苦味酸天狼星红染色观察心肌胶原数量；放免法测定血清透明质酸的含量；免疫组化染色观察致纤维化细胞因子—转化生长因子和血小板衍生生长因子的定量表达。

Demonstrative green tea can reduce gland purine to be damaged to the qualitative pathology between bandicoot kidney, green tea has fight the action that qualitative fiber changes between kidney, and can restrain hyperplasia of fibrous of I,Ⅲ collagen, this may be green tea qualitative fiber is changed between kidney of prevention and cure, one of mechanisms that defer chronic kidney failure to develop a process.

说明绿茶能够减轻腺嘌呤对大鼠肾间质的病理损害，绿茶有抗肾间质纤维化的功能，并且能抑制I、Ⅲ型胶原纤维的增生，这可能是绿茶防治肾间质纤维化、延缓慢性肾衰竭发展进程的机制之一。

The HE and the VG stain were pathologically examined and the expression of TGF-β1 and TNF-α mRNA in the lung tissues were analyzed by nucleic acid hybridization in situ. Results: YQHX1,2,3 obviously alleviated rats alveolitis and fibrosis.

结果：模型组肺泡炎和肺纤维化程度较重，且其胶原纤维沉积较多，TGF-β1、TNF-α的表达增多；而中药治疗组肺泡炎和纤维化程度较轻，胶原沉积明显减少，TGF-β1、TNF-α表达减少。

The pathological changes of liver were also improved in the treatment group.conclusionit implies that the extract of retinervus luffae fructus and carapax trionyei is beneficial for the prevention and treatment of hepatic fibrosis in balb/c rats.

肝组织病理观察结果显示复方针剂能缓解肝纤维化的发生和发展，并可加快降解增生的纤维组织。结论鳖甲复方针剂对con a在balb/c雄性小鼠中诱导肝纤维化有一定预防和治疗作用。

The influence mechanism of highly fibrillated BKP on HYP performances was discussed. The bonding between the fibers is well improved by a special bridge-link network structure formed by BKP fiber whiskers and HYP fibers, which greatly raises the strength properties of HYP.

探讨了高度细纤维化的BKP影响HYP性能的机理，发现高度细纤维化的BKP与HYP纤维形成的特殊桥联网状结构能很好地改善纤维间的结合，提高了HYP的机械强度。

The mechanism of action maybe include the depression in content of collagen, inhibition to proliferation of lung fibroblast, action of anti free redical and anti lipid peroxidation, and elevation of content of GSH-PX.So we think phenol total base of plumula nelumbinis is a sort of promising drug to healing PF.

综上所述，我们认为莲子心酚性总碱可能对肺纤维化的病理过程有多靶点作用：前期通过抗自由基作用，从而减轻肺泡炎损伤：后期直接抑制肺成纤维细胞的增殖及蛋白沉积，减轻纤维化病变程度。

Curcumine could improve experimental hepatic fibrosis and down-regulated the expression of leptin and leptin receptor in liver, which probably contributed to one of the mechanisms about anti-fibrosis.

姜黄素能明显改善实验性大鼠肝纤维化，同时下调肝纤维化大鼠肝脏中瘦素以及瘦素受体的水平，这可能是姜黄素抗肝纤维化作用的机制之一。

Compared with the control, the lungs of 3-day-hyperxia-exposure group developed into edema, hemorrhage and inflammatory infiltration and this condition aggravated at the 7th day. The pulmonary septum was significantly widened at the 14th day, the interstitial fibrocytes as well as alveolar epithelial cells proliferated obviously, and the tendency of lung fibrosis was also presented. The results mentioned above showed that the modle of hyperoxia lung injury was successfully established, and the acute inflamationm was its early symptom while the fibrosis was its late manifistation. There was no positive cytes of IFN-γ in the lung of nomal rats, The positive cytes of the groups under hyperxia-exposure for 3, 7, 14 day, which climbed to the climax at the 7th day and began to decline from the 14th day, were found in alveolus epithlia,pulmonary interstitial, bronchoepithlia and macrophage.

高氧14天（5.46±0.30）虽有所下降，但同空气组比，差异仍然具有显著性（P.05）；BALF中蛋白含量高氧3天（0.45±0.10）、7天（0.66±0.08）、14天（0.79±0.14）显著高于空气组（0.18±0.08，P值均。05）；肺通透系数高氧3天（6.61±2.05）、7天（10.88±1.54）、14天（12.75±2.20）均明显高于空气组（2.99±1.27，P值均。05）；同时病理组织学改变也表明与空气组比较，高氧3天时肺组织水肿、出血、炎性细胞浸润，7天时进一步加重，14天时肺间隔明显增宽，间质纤维细胞和肺泡上皮细胞明显增生，出现肺纤维化倾向；以上结果均表明我们成功地建立了高氧肺损伤动物模型，且急性炎症反应是其早期表现，纤维化改变是其晚期表现。

Make a copyof rat pulmonary fibrosis by infusing bleomycin through trachea , isolate and the pulmonary fibroblast, then interfered by atorvastatin ,divided into 3 groups of vacant ,TGF-β1 induced and atorvastatin interceped of different dosage , observe the structure of the cell by fiberscope ,the multiplication of the cell by MTT counting method, the expression of theα-SMA by immunity tissue chemistry staining method .

气管内注入博莱霉素（bleomycin，BLM）复制大鼠肺纤维化模型，并分离培养肺成纤维细胞，用阿托伐他汀对其进行干预，分为空白组、TGF-β1诱导组和不同剂量阿托伐他汀阻断组，用倒置纤维镜观察细胞的形态结构，MTT计数法观察各组细胞的增殖情况，免疫组化染色法定性观察α-平滑肌肌动蛋白(α-smooth muscleactin ，α-SMA)的表达情况。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。