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Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性,TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase,expression of TIMP-1,and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的:研究尿道瘢痕的细胞外基质的组成,尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响;比较胶原酶活性,金属蛋白酶组织抑制因子-1(TIMP-1)以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异;研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

HE staining revealed that collagen fiber, fibroblasts and granulation tissue and synechia belt around tendons and stomas were apparently less in contrast to control group.

术后4周苏木精-伊红染色结果表明,实验组腱吻合口被胶原纤维连接,腱周及吻合口周围胶原纤维、成纤维细胞及肉芽组织明显较对照组少,腱周纤维组织较对照组粘连轻,粘连带稀少。

Just for additional informations, Melange yarns can also be produced with other fibres too like Viscose, Rayon, Bamboo, Modal, Coolmax, Tancel, Soyabean, Cashmere, etc.

另外,用其他纺织纤维也可生产混色纱线,比如:粘胶纤维,人造棉,莫代尔,竹纤维,大豆纤维,羊绒,等。

4The Masson trichrome stain can be used for an important method for the observation of the fibrostic cells, The changes of the mast cell could be considered as an assist marker for the observation of the liver fibrogenesis.In addition the concentration of the hepatic hydroxyproline could be used for diagnosis of the hepatic fibrosis. clinical and experimental study.

Masson三色染色可以作为肝纤维化肝硬化组织细胞观察的一种重要方法:肝纤维化过程中,肥大细胞数量的动态变化,可以作为观察肝纤维化变化的一项辅助指标;肝脏羟脯氨酸的浓度变化可以作为肝纤维化的辅助诊断及应用于相关实验的研究。

Tests on road performance of SMA mixture with terylene long fiber and xylon fiber were conducted at both high temperature and low temperature. It was found that the resistances of lignin fiber to asphalt run-off, deflection at high temperature, and water damage were higher than those of terylene long fiber, while the effects of lignin fiber and terylene long fiber on anti-dispersion loss performance and anti-cracking performance at low temperature were basically similar.

通过沥青混合料路用性能试验,研究了涤纶长纤维与木质素纤维对SMA混合料高、低温等路用性质影响,发现同等掺量情况下,木质素纤维对SMA混合料抗析漏性能、抗高温变形性能和抗水损害的贡献好于涤纶长纤维;而二者对混合料的抗飞散损失性能和低温抗裂性能的影响基本相同。

The results show that Fe0.13[Co20Ni80]0.87 alloy fibers are characterized with thin diameters between 0.3 and 2.0 μm, with high aspect ratio, dense and smooth surfaces. The crystalline size of the alloy fibers are mainly influenced by the thermal reduction temperature and are in the range of 20 to 50 nm with a corresponding reduction temperature range of 300 to 700 ℃. The magnetic properties of the alloy fibers are largely affected by the carbon content and crystalline sizes of the alloy fibers. With increasing thermal reduction temperature, the coercivity decreases while the saturation magnetisation value of the alloy fibers dramatically increases at lower reduction temperatures. The alloy fibers prepared at reduction temperature of 700 ℃ have a saturation magnetisation value of 120 Am2/kg and a coercivity value of 10.4 kA/m, respectively.

结果表明:Fe0.13[Co20Ni80]0.87合金纤维的直径为0.3~2.0 μm,表面光滑、长径比大;组成合金纤维的晶粒大小与还原温度密切相关,当温度为300~700 ℃时,晶粒尺寸由约20 nm增加到约50 nm;该合金纤维显铁磁性,其矫顽力主要受合金中C含量及晶粒大小的影响,随制备温度的升高而降低;饱和磁化强度则主要与合金的组分相关,随还原温度的升高和合金纯度的提高而增大;经700 ℃热还原后,合金纤维的饱和磁化强度 m s为120 Am2/kg,矫顽力 H c为10.4 kA/m。

By micro-analysis on the aging fibers, it indicates that attack of alkali hydrates to vegetable fibers is serious and the flexibility becomes lower and the brittleness becomes increase for the calcium hydroxide crystal conglomerated in the fibers bosom.

通过对老化后纤维的微观分析发现,水泥水化后的碱性物质对天然植物纤维的侵蚀较大,Ca_2晶体在纤维内腔中的沉积使纤维的柔性降低,脆性增加,在长期干湿循环作用下,纤维水泥基材料的抗折强度下降。

A The slimmest single filament is most similar to F-actin in size with ~7 nm width at half height and ~35 nmpitch ; the filaments have much wider diameter than the slimmest F-actin ; The branch filament could be con-stituted of two enlaced slimmer filaments , forming the branch in the joining point of another filament ; Two fila-ments are aligned side by side , and thought that there might exist certain interaction between them , which could be theearly step for further assembly of giant filaments.

肌动蛋白可通过自组织过程聚合形成不同直径(7nm~35nm)的长纤维,实验中观察到的最细纤维的结构参数与单根无鬼笔环肽结合时的F-actin[19 ]一致(Fig。 2 a);此外,还有大量具有较大直径和分支结构的纤维出现,表明有不同于单根微丝和微丝束的高级纤维结构产生Fig。

The results show that the deposited boron from boric acid has catalytic-graphitization effect on carbon fibers through high temperature treatment, which enhances the graphitization property of carbon fibers and meliorates the surface state of carbon fibers.

结果表明:硼酸通过高温热处理过程所分解的硼对炭纤维起到了有效的催化石墨化作用,显著提高炭纤维的石墨化性能,改善炭纤维的表面状态,从而有效地促进CVI过程中炭纤维表面沉积较高织构热解炭。

Biology enzyme is adopted to deal with the rabbit wool fibre,which changes the modality and configuration of the rabbit wool fibre,improves fibre′s surface friction coefficient,fortifies the holding force among the fibres,enhances the spinnability,and meliorates the depilation of the rabbit wool textiles.

对兔毛纤维采用生物酶处理,使其形态结构发生改变,从而提高了兔毛纤维的表面摩擦系数,增加了纤维之间的抱合力,提高了纤维的可纺性,改善了兔毛纺织品的脱毛现象

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