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红血球

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The expression of N1IC doesn't affect the telomerase activity of K562 cells during erythroid maturation.

因此,Notch signaling对於红血球生成的调控扮演了举足轻重的角色。

Overexpression of N1IC, the cell proliferation was modulated, and erythroid maturation of K562 cells was suppressed.

结果显示N1IC的表现并不影响未分化与进行红血球系分化的K562细胞中端粒酵素活性。

For example, the transcription of mammalian α-globin gene is determined by the unique spatial arrangement of chromatin structure during erythroid differentiation.

举例来说,在红血球分化过程中α-globin的转录会受到染色体空间结构的调控。

In the biological functionaddition, both biochanin A and hesperitin might inhibited the colony -formation forming ability of K562 cells through up-regulated Notch signaling. Besides,The treatment with biochanin A and hesperitin enhanced the erythroid-differentiation of K562 cells. It is important to investigate Tthe molecular mechanisms of biochanin A and hesperitin to regulate the endogenous CBF1-dependent Notch signaling will be further investigated.

在生物功能方面,biochanin A与hesperitin可能经由Notch讯息传导的活化,抑制了K562细胞群落的形成,除此之外,这两种药物均明显促进K562细胞往红血球分化。biochanin A与hesperitin对於CBF1所媒介之内生性Notch讯息传导的分子调控机制仍有许多问题尚未厘清,需要更多的实验与研究来讨论。

It is not clear whether injecting the red blood cell residue into the hypodermal layer causes any untoward effect.

至於把这些红血球的沉积打入皮下,对於人体是否有影响并不清楚。

Deficiency of vitamin B12 may lead to megaloblastic anaemias and severe neurological damage.

缺乏维他命B12会导致巨胚红血球贫血,而对神经系统亦会造成严重的损害。

Megaloblastic anaemia (the red cells are megablastic ie large and abnormal) develops if vitamin B12 or folic acid are lacking.

巨贫血(红血球是megablastic即大和不正常的)发展,如果维生素B12或叶酸缺乏。

In a population of 11,770 NHANES participants from 1999 through 2004 who were 4 to 19 years old, the investigators looked at the relationship of headache with BMI; CRP; homocysteine levels; serum and red blood cell folate levels; vitamin B12; methylmalonic acid levels; total cholesterol, high-density lipoprotein cholesterol, and non-HDL cholesterol levels; triglyceride levels; uric acid levels; and platelet count.

在1999年到2004年之间,共有11,770位NHANES参与者,参与者的年龄介于4~19岁,研究者研究头痛与BMI、CRP、同半胱胺酸浓度;血清与红血球叶酸浓度;维生素B12;甲基丙二酸;总胆固醇、高密度脂蛋白、以及非HDL胆固醇浓度;三酸甘油脂浓度;尿酸浓度与血小板数目。

In a population of 11,770 NHANES participants from 1999 through 2004 who were 4 to 19 years old, the investigators looked at the relationship of headache with BMI; CRP; homocysteine levels; serum and red blood cell folate levels; vitamin B12; methylmalonic acid levels; total cholesterol, high-density lipoprotein cholesterol, and non-HDL cholesterol levels; triglyceride levels; uric acid levels; and platelet count.

在1999年到2004年之间,共有11,770位NHANES参与者,参与者的年龄介於4~19岁,研究者研究头痛与BMI、CRP、同半胱胺酸浓度;血清与红血球叶酸浓度;维生素B12;甲基丙二酸;总胆固醇、高密度脂蛋白、以及非HDL胆固醇浓度;三酸甘油脂浓度;尿酸浓度与血小板数目。

The sample particles studied in this project include human red blood cells, osmotically swollen into a micro-sphere, with and without treating with N-ethylmaleimide, and at different temperatures, as well as liposomes with different DOPC/cholesterol ratio (1:1 vs.1:3) For spherical RBCs, smaller deformation were observed in samples at room temperature with NEM treatment and samples at 42 ℃without NEM treatment, compared with the deformation of the control set, namely, RBCs at room temperature without NEM treatment.

这可能是由於42 ℃为红血球细胞骨架Spectrin的型态转换温度,Spectrin由tetramer转换成dimer。推测此温度及药物作用下对Spectrin的型态转换可能造成类似的效果。同时以自行合成DOPC/胆固醇比例(1:1)及(3:1)之微脂粒重覆上述之形变实验,发现两种组合比例微脂粒形变率的差异在误差范围内。

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