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红细胞破坏

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After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

The selfmade lysing solution can lyse red blood cells completely ,but not destroy leukocytes and influence the expression of surface antigens on lymphocytes, monocytes and granulocytes significantly.

自制流式细胞仪专用溶血素具有很好的红细胞溶解效果,但不破坏白细胞,且对淋巴细胞、单核细胞和粒细胞群表面抗原的表达无明显影响作用。

Damage or destruction of the transfused red cells is rare.

输注的红细胞受到伤害或破坏是很少见的。

As with red cells and platelets, these transfusions should be irradiated prior to transfusion, but should not be treated with leukoreduction filters, as this would defeat the purpose of transfusing white cells.

如同红细胞和血小板,粒细胞输注前也必须进行照射,但不能采用减白细胞过滤法,因为这样会破坏白细胞输注的目的。

As with red cells and platelets, these transfusions should be irradiated prior to transfusion, but should not be treated with leukoreduction filters, as this would defeat the purpose of transfusing white cells.

如同红细胞和血小板输注,粒细胞输注前也必须进行辐照处理,但不能采用减白细胞过滤法,因为这样会破坏白细胞输注的目的。

As with red cells and platelets, these transfusions should be irradiated prior to transfusion, but should not be treated with leukoreduction filters, as this would defeat the purpose of transfusing white cells.

与红细胞和血小板输注一样,粒细胞输注前也必须进行辐射处理,但不能经过减白细胞过滤,因为这样会破坏白细胞输注的目的。白细胞通过标准血液过滤器,除去其中的颗粒物和凝结的血液成分,但保留白细胞。

As with red cells and platelets, these transfusions should be irradiated prior to transfusion, but should not be treated with leukoreduction filters, as this would defeat the purpose of transfusing white cells.

这会为患者带来福音。与红细胞和血小板输注一样,粒细胞输注前也必须进行辐射处理,但不能经过去白细胞过滤,因为这样会破坏输注的目的。

Haemolysis test, prothrombin time and recalcification time experiment were used to evaluate influence on erythrocyte and blood coagulation function by CLG microspheres.

通过溶血实验、凝血酶原时间实验和复钙时间实验评价交联明胶微球对红细胞的破坏作用和对凝血功能的影响。

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