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红细胞分裂

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The immatured and dividing erythrocyte were found. The small lymphocytes with pseudopod and large lymphocytes with the villus were observed also. In addition, the monocyte, neutrophil and thrombu cells were recognized by different shapes of nucleolus.

实验还观察到处于分裂状态的红细胞、细胞表面有伪足样胞突的小淋巴细胞和细胞表面有许多微绒毛突起的大淋巴细胞、核呈多种形态的单核细胞和中性粒细胞及不同形态的血栓细胞等。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof P...

在12例慢性粒细胞白血病中,11例Ph~1染色体为阳性(阳性率平均为72.3%),1例为Ph~1阴性;2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5,其中1例还发现微小体;1例继发性红细胞增生症患者,70%的骨髓中期分裂细胞为Ph~1染色体阳性,并发现染色体碎裂细胞。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof Ph~1 chromoso...

在12例慢性粒细胞白血病中,11例Ph~1染色体为阳性(阳性率平均为72.3%),1例为Ph~1阴性;2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5,其中1例还发现微小体;1例继发性红细胞增生症患者,70%的骨髓中期分裂细胞为Ph~1染色体阳性,并发现染色体碎裂细胞。

Results indicated that suppression of malignancy was observed in the hybrid cells, they became differentiated morphologically and functionally by:(1) changes in histochemical staining, nucleus-cytoplasm in ratio, and increase in cell size and nucleal heterochromation, but decrese in cell surface microvilli and number of nucleoli;(2) decrease of growth rate, mitotic index and DNA synthesis rate;(3) loss of the ability to growth in soft agar medium, and non-tumorigenic under heterotransplantation to nude mice;(4) reduction of chromosome number mainly of rat derivative and decrease in chromosomal aberration rate.

实验结果表明:(1)杂交细胞出现瘤细胞与网织红细胞杂交同样的表型逆转及去恶性化特征,主要表现在细胞体积增大、核质比例减小;DNA合同速率降低、分裂指数下降,细胞生长显著减慢;在软琼脂中不形成集落,在裸鼠体内失去了长瘤能力。

On low-magnification light microscopy, the specimen had a patternless tissue culture-like appearance with increased mitotic actiity, randomly oriented spindle cells, and extraasated red blood cells (Figure 2B ).

低倍光学显微镜下,标本显示无图案的&组织培养样&表现,伴有有丝分裂活性增高、未定性的梭形细胞和红细胞外渗(图2b),组织病理学所见符合结节性筋膜炎。

Figure 2.B, On high-power magnification microscopy, the specimen showed a patternless tissue culture-like appearance with multiple mitoses and extraasated red blood cells.

图2B,高倍显微镜检查,标本显示无图案的&组织培养样&表现,伴有大量有丝分裂和红细胞外渗。(缩略图,点击图片链接看原图

In addition, Immature erythrocyte, neutrophil and direct dividing of erythrocyte could also be observed on the smears.

并发现较多未成熟的红细胞以及少量正在分裂的红细胞和晚幼嗜中性粒细胞。

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