紧密封闭

China is North Korea's closest ally and the most important trading partner of its reclusive neighbor.

中国是朝鲜最紧密的盟友，并是这个封闭的邻国的最重要贸易伙伴。

The temporary closure must tightly seal the coronal trepanation opening between appointments, in order to prohibit any bacterial penetration into the root canal system.

为避免细菌渗漏入根管系统，在根管治疗两次预约之间的暂封必须紧密封闭牙冠上开放的桶状开髓洞形。

The temporary closure must tightly seal the coronal trepanation opening between appointments, in order to prohibit any bacterialpenetration into the root canal system.

为避免细菌渗漏入根管系统，在根管治疗两次预约之间的暂封必须紧密封闭牙冠上开放的桶状开髓洞形。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

Objective: To investigate the effects of high glucose peritoneal dialysis solution and "Astragalus Injection" combined with peritoneal dialysis solution on tight junction of peritoneal mesothelial cells and the expression of zonula occluden-1(ZO-1) in rats.

目的：观察高糖腹膜透析液和添加不同剂量黄芪注射液的腹膜透析液对腹膜间皮细胞紧密连接形态结构和紧密连接相关蛋白封闭蛋白－1(ZO-1)表达的影响。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。