素因子

November 9, 2007 — Researchers say that the integrin-transforming growth-factor beta axis is involved in the development of fibrosis and that by blocking integrin beta 6, pulmonary toxicity can be prevented and possibly even reversed. The promising preliminary results testing the new monoclonal antibody being developed by Biogen Idec were presented at plenary here at the 49th annual meeting of the American Society for Therapeutic Radiology and Oncology.

November 9， 2007—研究者表示，整合素转化生长因子β轴（integrin-transforming growth-factor beta axis）包含於发生纤维变性之中，且藉由阻断整合素β6，可以预防肺毒性甚至逆转；此一大有可为的初步结果检验了由Biogen Idec所发展的新的单株抗体，发表於美国治疗放射暨肿瘤学会第49届年会全体会议中。

Tumstatin is the fortest antiangiogenesis factor in present, its effect is more than 10 times as endodermis chalone.

肿瘤抑素是目前发现的最强的血管生成抑制因子，作用强于内皮抑素10倍以上。

MAIN OUTCOME MEASURES: At 3, 7, 14, 28 days after the application of traction and 3, 7, 14, 28 days after the removal of traction, the expression of receptor activator of nuclear factor κB ligand/osteoprotegerin in the subchondral bone of the bilateral condyles was analyzed by semi-quantitative immunohistochemistry.

主要观察指标：加力3，7，14，28 d及撤除外力后3，7，14，28 d，以免疫组织化学半定量检测双侧髁状突软骨下骨中核因子κB受体活化因子配基/骨保护素表达。

METHODS: The presence and number of recently developed extra-articular manifestations and a weighted EAM score, as well as the levels of serological markers, were compared between 31 patients with RA with histologically proven vasculitis and 50 patients with RA in whom vasculitis could not be documented histologically. The following markers were evaluated: circulating immune complexes, complement components C3 and C4, class-specific rheumatoid factors, antineutrophil cytoplasmic antibodies, antinuclear antibodies, antiendothelial antibodies, circulating intercellular adhesion molecule-1 and -3, circulating vascular cell adhesion molecule and E-selectin, cellular fibronectin, von Willebrand factor antigen, and C reactive protein.

对比组织学上已证实有血管炎的31例 RA 例和组织学上无血管炎的50例 RA 患者间的临床及血清学标记物，这些资料包括最近发生的关节外表现数量、关节外表现加权得分、循环免疫复合物、补体 C3和 C4、类风湿因子（ IgM-RF，IgG-RF，IgA-RF ）、抗中性粒细胞胞浆抗体、抗内皮细胞抗体、循环细胞间粘附分子-1和-3、循环血管内皮粘附分子和 E-选择素、细胞纤连蛋白、假性血友病因子抗原（ von Willebrand factor antigen ）及 C-反应蛋白。

Materials and Methods Thirty SD rats, feeding in clearing grade standard, were classified into five groups at random. Application of transmission electron microscopy, scanning electron microscopy, light microscopy and immunohistological staining meth- ods, normal morphology of outflow pathways was observed and component of extra cel- lular matrix was defined. The effects of 50 IU of TNF-α given intracamerally on the morphology of outflow pathways and other tissues of anterior segments, expression of trabecular stromelysin and the change of components of trabecular extra cellular matrix were observed in 24h, 3days, 7days and 14days after injection.

中文题名TNFα对鼠眼房水外流影响的形态学观察副题名外文题名 The effect of TNFα on morphology of outflow pathways in rat eyes 论文作者王大博导师王竫华教授学科专业眼科学研究领域\研究方向学位级别博士学位授予单位青岛大学学位授予日期2002 论文页码总数90页关键词青光眼房水外流通道肿瘤坏死因子-α馆藏号BSLW /2003 /R775 /1 目的在观察SD大鼠眼房水外流通道形态及确定其房水外流通道细胞外基质成份的基础上，探讨房水中肿瘤坏死因子α浓度的增加是否能诱导小梁细胞基质溶解素的表达和分泌，进而启动小梁细胞外基质的重塑过程。

These include such medications as colchicine, bisphosphonates and hormones; dietary therapeutics, such as ginger extract and green tea; and such truly experimental treatments as matrix metalloproteinase inhibitors, cytokines, nitric oxide, growth factors and gene therapy.

这些疗法包括药物治疗如秋水仙素，二磷酸盐和激素；饮食治疗，如姜汁和绿茶；还有试验性治疗象基质金属酶蛋白抑制剂，细胞因子，氧化亚氮，生长因子和基因治疗。

Basic fibroblast growth factor ; lymphokine activated killer cells ; cell division ; interleukin 2; bladder neoplasms ; immunologic cytotoxicity

碱性成纤维细胞生长因子；淋巴因子激活的杀伤细胞；细胞分裂；白细胞介素-2；膀胱癌；免疫细胞毒性

Conditions placing persons at prolonged increased risk for meningococcal disease include persistent complement component deficiencies (such as C3, properdin, Factor D, and late complement component deficiencies), anatomic or functional asplenia, and prolonged exposure (eg, microbiologists routinely working with Neisseria meningitidis, or travelers to or residents of countries where meningococcal disease is hyperendemic or epidemic).

使人们持续处於感染脑膜炎球菌疾病高风险的因子，包括持续的补体缺乏（例如C3、备解素、D因子、以及后期补体缺乏），解剖或是功能性脾脏功能丧失、以及延长暴露（例如经常处理奈氏脑膜炎球菌的微生物学家、或是到脑膜炎球菌大流行或流行国家旅行或居住的人们）。

Objective To observe the effects of physical agents therapy on serum hsCRP, TNFα and adiponectin in patients with cerebral infarction and the possible underlying mechanisms.

目的观察物理因子治疗对脑梗死患者血清高敏C反应蛋白，肿瘤坏死因子α和脂联素水平的影响，并探讨其可能机制。

The secret to Ellgy h 2 o is two unique ingredients: Anti-TEWL acts like a "water lock" to seal in essential moisture, while DPHP helps prevent enzymatic breakdown of elastin, which also helps prevent premature ageing of the skin.

其独特的 Anti - TEWL 锁水因子，能有效发挥「锁水」功能，防止水份经角质层失，将水份因子锁紧於肌肤之内。此外，优姿 h 2 o 亦含有 DPHP，能有效地防止弹性蛋白纤维被酵素分解，保持肌肤弹性，回青春。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。