素因子

Been used to express insulin, human growth factor, human tissue plasminogen activator, bovine chymosin (an enzyme used in cheese-making), and amylase and cellulase enzymes .

用作带有真核生物基因的载体的宿主用来表达胰鸟素、人类生长因子，人类组织血浆酶原活化因子，牛凝乳酶，淀粉酶、纤维素酶等。

MATERIALS: Six adult New Zealand clean rabbits of either gender were included in the present study.METHODS: Tendon sheath fibroblasts, epitenon tenocytes, and endotenon tenocytes were isolated from rabbit flexor tendon and cultured.

目的：探讨兔屈趾肌腱腱鞘、腱外膜和腱内膜细胞增殖、胶原产生和乳酸对细胞的增殖、胶原产生和对转化生长因子β1，基础纤维母细胞生长因子，白细胞介素8分泌的影响。

Objective To evaluate the damage degree of hydronephrotic kidneys by detecting insulin-like growth factor (IGF-1), endothelin (ET-1), transforming growth factor (TGF-β1) and monocyte chemoattractant protein (MCP-1) expression in children with hydronephrosis.

目的 检测肾积水患儿病肾肾组织胰岛素样生长因子(IGF-1)、内皮素(ET-1)、转化生长因子(TGF-β1)及单核细胞趋化蛋白(MCP-1)的表达变化，探讨其与病肾损害程度的关系。

Objectives To study the expressions of STAT1 and PDGF in lung tissue of pulmonary fibrosis model induced by bleomycin in rats, and discuss the possible mechanism.Methods Thirty Wistar rats were randomly divided into two groups (15 in each group), they were bleomycin group and control group.①The BLM group was intratracheally instilled with belomycin (5mg/kg);② NS group was intratracheally instilled with saline (5mg/kg).

目的 观察肺纤维化鼠肺组织信号转导和转录活化因子1（STAT1）和血小板源性生长因子表达的变化，探讨其在肺纤维化的作用机制方法 30只Wistar大鼠随机分博莱霉素组和对照组，①BLM组：气管内灌注BLM（5mg/kg）诱导肺纤维化；②NS组：气管内灌注NS。

Methods: Based on the theory of "kidney produces sui", we set up MCAO rat model. Five indexes including Nestin, PSA-NCAM, MAP-2, GAP-43 and SYN38 were measured in situ hybridization and immunohistochemical methods to evaluate the effects of Fujian Tablet on the proliferation, migration, differentiation of neural stem cells, axonal growth and synapse formation. Other two indexes including trk-B, NOGO-A were used to assess the effects on the neurotropic factor and inhibitory factor.

以&肾生髓&的理论为依据，以MCAO大鼠为实验对象，利用原位杂交技术和免疫组织化学方法，分别以nestin、PSA-NCAM、MAP-2、GAP-43、突触素p38为指标，观察复健片对神经干细胞增殖、迁移、分化、轴突生长、突触形成的影响；分别以trk-B、NOGO-A为指标，观察复健片对神经生长营养因子、抑制因子的影响。

VEGF and the classification that its accept put oneself in another's position and action mechanism VEGF say blood-vessel is connected again appear factor (Vascular Permeabilityfactor, VPF) or blood-vessel are opsonic , it is right blood-vessel forms those who have main effect to grow factor.

VEGF及其受体的分类和功能机制VEGF又称血管通透因子(vascular permeabilityfactor，VPF)或血管调理素，是对血管形成具有重要功能的生长因子。

Monocytes generated from bone marrow of Balb/cj mouse were cultured for 6 days in complete RPMI 1640 medium containing 10％ FBS, rmGM-CSF and rmIL-4.50 mg·L-1 acteoside or isoacteoside was added to cells on day 6 of culture for 24 h.The surface molecules expression level of DCs and their phagocytose ability were analysis by flow cytometry.

采用细胞因子诱导法，从Balb/cj小鼠骨髓细胞贴壁分离获得单核细胞，加入含10%胎牛血清、10 μg·L-1重组小鼠粒细胞巨噬细胞集落刺激因子及重组小鼠白细胞介素-4(rmIL-4)的RPMI 1640完全培养基培养，在培养第6天，实验组加入车前子苯乙醇苷类化合物(10，50，100 mg·L-1)，对照组加入RPMI 1640或LPS(1 mg·L-1)，流式细胞仪检测DCs表面分子CD11c，CD86，MHC II和CD80的表达以及各组DCs吞噬功能的变化。

Basic on the special mechanism of action of Apo2L/TRAIL, the broad-spectrum antitumor activity and superordinary safety of recombinant human soluble Apo2L/TRAIL in preclinical researches, and the progression of the antitumor study on endogenous antiangiogenic factors, two studies were involved in this paper, including phase I clinical trial of rh-Apo2L and the study on expression of the fusion proteins of human Apo2L and endogenous antiangiogenic factors.

基于Apo2L／TRAIL独特的作用机制、重组人可溶性Apo2L／TRAIL临床前体现出的广谱的抗肿瘤作用和良好的安全性、以及内源性血管生成抑制因子抗肿瘤研究进展，本课题开展了下述两方面的研究：①国产重组人凋亡素2配体(rh-Apo2L)的Ⅰ期临床研究；②人Apo2L／TRAIL与人血管生成抑制因子融合表达的基础研究。

Wagener FA, Eggert A, Boerman OC, Oyen WJ, Verhofstad A, Abraham NG, Adema G, van Kooyk Y, de Witte T, Figdor CG. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 2001;98(6):1802-1811.11 McCoubrey WK Jr, Huang TJ, Maines MD.

推测其作用机制可能有以下几个方面：(1)研究证实，在EAE的发生和发展中，有多种炎性细胞因子，如白细胞介素-1、2，肿瘤坏死因子a和干扰素g发挥着重要作用，他们的存在进一步激发了HO-1的表达[17]。

In this study, 105 TDFs were in silico mapped in the rice high-density linkage map. Nineteen TDFs were mapped to the quantitative trait loci regions for root growth under water-limited conditions in, at least, two of three rice populations derived from three crosses with the same parent of Azucena (Bala×Azucena, IR64×Azucena and IR1552×Azucena). Four of 19 genes (T37, L16, T17 and T7) were mapped based a RIL population of IR1552×Azucena by southern blot analysis. Five genes encode putative or hypothetical protein. Other 14 genes were similar with known genes in databases including expansin (OsEXP2), late embryogenesis-abundant gene , an SR-related protein essential for spliceosome assembly (SART1), autophagocytosis protein , bHLH protein, fruit-ripening protein similar to ASR, nickel-binding protein 2A, DNA-binding protein, pyruvate dehydrogenase kinase , stomatin-like protein, SR1 induced by sucrose starvation, vacuolar protein sorting protein (VSP33a), gibberellin action negative regulator and retroelement.

根据核苷酸序列将105个基因电子定位到水稻的高密度连锁图谱上，其中19个差异表达基因定位在Bala×Azucena、IR64×Azucena和IR1552×Azucena中至少两个群体共同的与根生长相关的QTLs区间，并用Southern杂交将其中的4个定位到IR1552×Azucena群体遗传连锁图谱相应的位点上。19个基因中的5个编码推断的未知功能蛋白质，其余14个编码已知功能蛋白，分别为膨胀素（Os-EXP2）、胚胎后期丰富蛋白、剪接体安装必需的SR相关蛋白（SART1）、自吞噬蛋白、碱性螺旋-环-螺旋转录因子、与ASR相似的果实成熟蛋白、镍结合蛋白、DNA结合蛋白、丙酮酸脱氢酶激酶、stomatins类蛋白、蔗糖调节蛋白SR1、液泡蛋白分类蛋白（VSP33a）、GA负调节因子、逆转座元件。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。