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糖血症

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By measuring changes of Plasma levels of GMP-140, GP lib/III a and D-dimer in patients with OSAS before and after the institution of nasal continuous positive airway pressure, we want to study whether plate activation and enhance coagulability, fibrinolytic activation occur and play a role in prevalence ofcerebrovascular and cardiovascular events in patients with OSAS and the association with hypoxemia, if so, whether therapy with nCPAP alters this effect.

我们通过检测OSAS患者血浆α-颗粒膜蛋白(GMP-140)、血小板膜糖蛋白Ⅱb/Ⅲa和D-二聚体的变化,了解OSAS患者体内是否也存在血小板活化、凝血激活和继发纤溶亢进及其与低氧血症的关系,进一步从分子生物学角度探讨血小板活化、凝血激活和继发纤溶亢进在OSAS发生发展中的作用及经鼻持续气道正压通气对其影响。

At present, antihypertensive druggery have not been proved to take effective actions in preventing hypertension and the metabolic syndromes, let alone concomitance dyslipidemia and glucose intolerance. So we got a kind of mixture called"Tangzhixiao"by mixing extracts from modern medicine and Chinese traditional medicine.

考虑到目前抗高血压药物改善IR的作用不明显,对伴发的高脂血症及糖耐量减退效果更不肯定,因此,我们近年来从祖国医学与现代医学结合的视角出发,组方成药物"糖脂消"。

According to the report, patient of our country coronary heart disease metabolization of 80% existence candy is unusual, but the research report that waits for chronic illness influence to hypertensive, fatty liver, coronary heart disease, tall lipemia about tall blood sugar is less.

据报道,我国冠心病患者80%存在糖代谢异常,但有关高血糖对高血压、脂肪肝、冠心病、高脂血症等慢性疾病影响的探究报道较少。

Methods: 1. Rats in the study were divided into six groups: normal control group, hyperlipidemia group (fed with high-cholesterol diet), atherosclerosis group (vitamin D〓 intramuscular injection, endothelium denudate and fed with high-cholesterol diet with vitamin D〓), L-arginine group (besides treatment as atherosclerosis group, 2.25% L-arginine was added in the drinking water), chitosan group (besides treatment as atherosclerosis group, 5% chitosan was added in the diet), simvastatin group (besides treatment as atherosclerosis group, 0.03% simvastatin was added in the diet). The study lasted 90 days.

1。实验大鼠分为6组:正常对照组、高脂血症组、动脉粥样硬化组(维生素D〓肌肉注射加动脉球囊损伤手术加含维生素D〓的高脂饲料饲养)、L-精氨酸组(动脉粥样硬化组基础上饮水中加入2.25%L-精氨酸)、几丁糖组(动脉粥样硬化组基础上饲料中加入5%几丁糖)、辛伐他汀组(动脉粥样硬化组基础上饲料中加入0.03%辛伐他汀),90天后取标本检测。2。

Our overall conclusions are that there is considerable evidence that relative hyperglucagonemia contributes to fasting and postprandial hyperglycemia in patients with T2DM, and there are several new and emerging pharmacotherapies that may improve glycemic control in part by ameliorating the hyperglycemic effects of this relative glucagon excess.

我们的总结论是大量的资料表明相对的高胰高糖素血症可导致T2DM病人的空腹和餐后高血糖,新出现的几种药物疗法可以通过改善相对胰高糖素过剩引起的高血糖从而部分的提高血糖控制能力。

Objective To make high glucose and hyperlipidemias models and study on relation between disturbance of lgucose and lipide metabolism and DM.

目的通过高糖、高脂血症动物模型,观察糖、脂代谢紊乱对机体的影响及与糖尿病的关系。

DH level, CD4+ T lymphocyte count below 100 × 106/L, and interstitial pneumonia or ground-glass shadow in chest images, the diagnosis of PCP could be made presumptively. It is difficult to make a nosogenic diagnosis of PCP, but TBB considerably increases the positive rate of pneumocystis. Compound sulfamethoxazole is recommended as the first selected drug. In severe cases, corticosteroid and assisted mechanical ventilation combined with compound sulfamethoxazole could remarkably improve the prognosis of PCP.

当AIDS患者出现发热、咳嗽、呼吸困难、低氧血症、LDH增高及CD4+T淋巴细胞<100×106/L时,结合胸部影像间质性肺炎或磨砂玻璃样改变,临床需考虑PCP;病原学诊断困难,但TBB肺孢子菌检出率高;治疗首选SMZ-TMP,重症病例辅以糖皮质激素和机械辅助通气可改善预后。

Methods 59type2diaˉbetes mellitus with blood hyperviscosity were invotved in a randmoized control clinical trial.30cases were treated with PGE 1 200μg solved in500ml inj dextran lowmolecular intravenously everyday for3weeks.29cases treated with the same basic hypolycemic therapy and blood-lipid lowering drugs as the PGE 1 group except500ml inj dextran lowmolecular inˉtravenously everyday for3weeks as controls.

59例糖尿病合并高粘血症患者随机分组对照观察,前列腺素E 1 治疗组30例给予前列腺素E 1 注射液200μg溶于低分子右旋糖酐注射液500ml中静滴,每日1次,共3周;对照组29例降血糖、降血脂等基本治疗与前列腺素E 1 组相同,另外只给予低分子右旋糖酐注射液500ml静滴,每日1次,共3周。

Methods 59type2diaˉbetes mellitus with blood hyperviscosity were invotved in arandmoized control clinical trial.30cases were treated with PGE 1200μg solved in500ml inj dextran lowmolecular intravenously everyday for3weeks.29cases treated with the same basic hypolycemic therapy and blood-lipid lowering drugs as the PGE 1group except500ml inj dextran lowmolecular inˉtravenously everyday for3weeks as controls.

方法59例糖尿病合并高粘血症患者随机分组对照观察,前列腺素E 1治疗组30例给予前列腺素E 1注射液200μg溶于低分子右旋糖酐注射液500ml中静滴,每日1次,共3周;对照组29例降血糖、降血脂等基本治疗与前列腺素E 1组相同,另外只给予低分子右旋糖酐注射液500ml静滴,每日1次,共3周。

Objective:To make animal models of "high glucose"and "hyperlipidemia" and observe the effects of high glucose and hyperlipidemia on rats.Method:Vascular function detection,tissue culture and radioactivity analysis methos were used.

复制高糖、高脂血症动物模型,采用血管功能检测、组织培养及放射免疫分析方法观察高糖、高脂对大鼠机体的综合影响并探讨其发病机制及治疗原则。

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