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Diabetic retinopathy may affect 98% of diabetic patients, but its aetiology is poorly understood.

98%的糖尿病患者都受到糖尿病视网膜病变的影响,但是具体病因仍不清楚。

In the early stage of STZ diabetic, administering BDNF protein into the vitreous cavities can increase TH protein levels and the density of dopaminergic amacrine cells in the STZ rats' retina.

在STZ糖尿病大鼠糖尿病早期,玻璃体腔内注射BDNF可提高视网膜中TH的水平,提高多巴胺能无长突细胞的数目。

METHODS: Adult male Wistar rats, 9 weeks of age, were injected intraperitoneally with STZ to create diabetes. At 2 week after the models were created, BDNF protein was administered into the vitreous cavities of rats. At 4 week after the models were created, the rats were killed and the retina was removed for Western blotting and Whole-mount immunohistochemistry for TH to observe the changes of TH and dopaminergic amacrine cells in retina.

9周龄Wistar大鼠,链脲佐菌素(streptozotocin,STZ)腹腔注射,制成糖尿病模型,于模型建立2wk后,大鼠眼玻璃体内注射BDNF溶液,于模型建立4wk后,处死大鼠,取出眼球,取视网膜组织进行Western blotting及视网膜铺片免疫组织化学染色检测,观察视网膜中TH水平的变化,从而反映糖尿病大鼠视网膜中多巴胺能无长突细胞水平的变化。

Objective: To explore the expression of anaphase promoting complax in renal tissues of diabetic rats, and to investigate its contribution to the change of Ski-related protein N in diabetic nephropathy.

目的:观察APC10在糖尿病大鼠肾组织中的表达变化,并初步探讨其与糖尿病肾病发生发展中SnoN蛋白表达变化的关系。

Objective: To investigate the associativity between identify signs and pattern types for diabetic foot and expression of α-actin in muscle of amputation.

目的:研究糖尿病足截肢标本肌肉内α-肌动蛋白的表达与糖尿病足中医辨证分型的相关性。

Objective To study the relationship between the severity of carotid atherosclerosis and serum lipid level in type 2 diabetes.

目的 观察糖尿病患者颈动脉粥样硬化的程度,探讨2型糖尿病患者血脂与颈动脉硬化的关系。

The elderly type2diabetes were easy to combine with the infection of urinary system;Choosing drugs according to drug sensitivity results and treat the asymptomatic bacteriuria, are necessary to control the urinary infection.

老年2型糖尿病患者易合并泌尿系感染,根据药敏结果合理选药及针对无症状菌尿的治疗,是控制老年糖尿病合并泌尿系感染的必要手段。

Because corticosteroid can modify the immunological process which is considered the major mechanism involved in AHS, it is used to treat AHS clinically. However, corticosteroid therapy may have deleterious effect (e.g., delayed healing of cutaneous lesions, infections, prolonged hospital stay). Therefore, the use of corticosteroids for AHS remains controversial. We reported a 54-year-old man who had underlying diabetes mellitus with chronic renal insufficiency, hypertension and hyperlipidemia. Allopurinol 100mg twice a day was initiated one month prior to admission. After taking the drug for 24 days, he developed a generalized mild itchy eruption on the trunk and upper extremities followed by chillness, fever, ocular discomfort and painful oral ulcer over one-week period and was admitted to the hospital. A skin biopsy revealed changes consistent with Stevens-Johnson syndrome.

本文报告一位54岁的男性患者,有高血压、高血脂、糖尿病及慢性肾脏功能不全的病史,最近发现有高尿酸血症(11.1mg/dL)而开始服用Allopurinol,在服用24日后,因为逐渐发生皮肤红疹搔痒、口腔溃疡、发烧、畏寒以及眼睛不适,一周之后到医院就医,经诊断为服用Allopurinol所造成之史帝文森-强生症候群(Stevens-Johnson syndrome),因而在皮肤科住院接受治疗,由於病人有高血压、高血脂及糖尿病,所以入院后仅以支持疗法,并未给予全身性类固醇,然而病人之病况恶化,并有肾功能恶化,因而於住院两日后,转进肾脏科病房,在使用全身性类固醇治疗之后,病况持续改善,并在2周后出院。

ConclusionThe examination and therapy of diabetic retinopathy should be a part of the diabetes system consociation treatment.

结论糖尿病性视网膜病变的检查、治疗应成为糖尿病系统联合治疗的一部分。

Objective: To explore the feasibility of decimeter wave therapy in diabetic macroangiopathy through observing the effect of decimeter wave on matrix metalloproteinase-9(MMP-9) expression.

目的:观察分米波对2型糖尿病大鼠主动脉MMP-9表达的影响,探讨分米波治疗糖尿病大血管病变的可行性。

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