糖尿病的

RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病，1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖；应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia；一色恤~﹁染澎糕行HE染色观察组织病理学孪叱；胶质细胞原纤维酸性蛋白protellZ，Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分，应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

Serum levels of TIMP-1 were gradually increasing with the progression of diabetic nephropathy,The results strongly suggested that TIMP-1 may contribute to vascular remodeling during the development and progression of high blood pressure and atherosclerosis. Meanwhile, TIMP-1 may mediate remodeling of glomerular basemment membrane and glomerulos-clerosi and plays an important role in the development and progression of diabetic nephropathy.

随着糖尿病肾病的病情进展，血清中TIMP-1水平逐渐增高，提示TIMP-1可能参与了糖尿病患者动脉硬化、动脉粥样斑块的形成及高血压的血管重塑过程；TIMP-1可能介导了肾小球ECM积聚，肾小球基底膜重塑、肾小球硬化，在糖尿病肾病发生、发展过程中起着重要作用。

Results: Expression of PAI1,TIMP1 and FN in kidney of diabetic rats began to increase in the second week of diabetes; PAI1 and TIMP1mainly expressed in intracytoplasm of renal tubular epithelial cells, while FN mainly expressed in renal tubule matrix and glomerului; Their expression showed a tendency of increasing along with the progression of diabetes.

本实验以糖尿病大鼠为动物模型，动态观察糖尿病2周、4周、8周、16周大鼠肾脏PAI1、TIMP1及FN表达的变化，从ECM代谢的角度探讨PAI1和TIMP1在糖尿病肾病肾纤维化发病机制中的作用。

Methods］By observing the cytoplasmic Ca2+ concentration change of single cardiocyte in I/R status and the effect of Na+/H+ permutoid retarder to Ca2+ concentration in different phases (diabetes pure oxygen-lack deficit group called DM group,the oxygen deficit/reaeration on entire journey for medicine group called DM-EIPA group, the first group giringmedicine before reaeration on called DM-EIPA 1 group, and the second group giringmedicine before reaeration on called DM-EIPA 2 group) to detect the protection mechanism of Na+/H+ permutoid retarder to diabetic mouse cardiac muscle cell oxygen deficit/reaeration injury.

方法］ 通过观察糖尿病鼠单个心肌细胞在缺氧/复氧时细胞胞浆Ca2+浓度的动态变化以及Na+/H+交换体阻滞剂在不同时相（糖尿病单纯缺氧组即DM组，缺氧/复氧全程给药组即DM-EIPA组，复氧前给药1组即DM-EIPA 1组，复氧前给药2组即DM-EIPA 2组）对Ca2+浓度的影响来研究Na+/H+交换体阻滞剂对糖尿病鼠心肌细胞缺氧/复氧损伤的保护机制。

Methods: The experimental type Ⅱ diabetic rats were induced by injection of strepiozotocin (STZ, 30mg/kg ) and fed with high fat and high glucose fond. The rats were divided into three groups: a normal conrmal control group, a diabetes group and a treated group. The treated group were hypodermically injected insulin 3U/d at interfemus for 4 months, white DC and NC group were vehicle groups that were treated with the same close saline, By using SABC method, thee express ion of collagen type Ⅰ and Ⅲ in SAN was detected.

高糖高脂饮食加小剂量链脲佐菌素腹腔注射(STZ，30mg/kg)制备Ⅱ型糖尿病大鼠模型，并随机分为正常对照组、糖尿病组和胰岛素治疗组（每只3U/d股内侧皮下注射），对照组和糖尿病组注射等剂量的生理盐水每天1次，持续4个月；窦房结组织行SABC法免疫组织化学显色，检测窦房结组织中的Ⅰ型和Ⅲ胶原的表达及变化。

Methods Systemic health education and life intervention were conducted among the DM patients in the form of the sodalities of the ward mates in community.

方法以社区糖尿病病友联谊会的活动形式，对社区糖尿病病人进行系统的糖尿病教育和生活干预。

Objective: The aim of this study was: to quantify the cariogenic bacteria of dental plaque in the diabetic elders, compared with the healthy; to analyze the association between dental plaque bacteria and diabetic factors; to evaluate the caries risk of diabetic elders according to pathogenesis.

目的：定量比较老年2型糖尿病患者与正常人牙菌斑龋相关细菌，探讨糖尿病相关因素与牙菌斑龋相关细菌组成的关系，从病因学角度评估老年糖尿病患者的患龋风险性。

The diagnosis criteria of diabetic nephropathy : diabetic family history; repeated three times observation UAE=30mg/d; urine was major of proteinuria, haematuria was rare; with Retinopathy;without of these criteria, with renal biopsy confirmed.

2糖尿病肾病的诊断标准：糖尿病家族史；连续三次尿微量白蛋白≥30mg／d；尿中以蛋白尿为主，血尿少见；伴视网膜眼底病变；不符合上述标准的，则肾组织活检证实为糖尿病肾病。

Both cyanocobalamin and methylcobalamin can effectively decrease the level of total homocysteine in type 2 diabetic mice with hyperhomocysteinemia, and delay the progression of renal disease of type 2 diabetic mice.

氰钴胺和甲钴胺注射治疗均能有效降低2型糖尿病小鼠tHcy水平。tHcy可能促进2型糖尿病小鼠肾脏病变的发生和发展；而氰钴胺和甲钴胺可能通过降低tHcy水平，减缓2型糖尿病小鼠肾脏病变的进展。

Karen Addington, Chief Executive of Juvenile Diabetes Research Foundation, added: Chronic wounds and diabetic foot ulcers are serious long-term complications of type 1 diabetes.

青少年糖尿病研究基金会的主管Karen Addington补充：慢性伤口和糖尿病组溃疡是1型糖尿病严重的长期并发症。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。