糖尿病的

Diabetic foot is also called acromegaly necrosis diabetes, diabetes is one of the most serious complications, diabetes is also an important cause of disability to death.

糖尿病足又称糖尿病肢端坏死，是糖尿病最严重的并发症之一，也是糖尿病致残致死的重要原因。

The frequency of heart circulation disease occuring is evidentially higher in diabetes patients and in people without diabetes.

糖尿病患者心血管疾病的发生率明显高于非糖尿病患者，因糖尿病心脏病而死亡的人数约占糖尿病患者死亡率的80％，其中70％是死于糖尿病性冠心病。

In three separate studies, the investigators evaluated 105 adults with type 1 diabetes (mean age, 37 years; mean duration of diabetes, 20 years), 36 adults with type 2 diabetes (mean age, 50 years; mean duration of diabetes, 10 years), and 91 adults with type 1 diabetes (mean age, 39 years; mean duration of diabetes, 20 years). During a four-week period, participants used a hand-held computer to complete 70 trials of cognitive-motor tasks and to enter their current blood glucose reading after each test. Hyperglycemia was defined as blood glucose level higher than 15 mmol/L.

在3个不同的试验中，研究人员评估105位第1型糖尿病患者（平均年龄为37岁；患糖尿病平均时间为20年），36位第2型糖尿病患者（平均年龄为50岁；患糖尿病平均时间为10年），以及91位第1型糖尿病患者（平均年龄为39岁；患糖尿病平均时间为20岁）；在4周期间，受试者使用一种掌上型电脑来完成70种认知运动任务的试验，以及在每次测试后，输入他们目前的血糖读数，血糖高於15 mmolL被定义为高血糖。

The results showed an increased mean jitter value, fiber density and abnormal percentage both in EDC and AT muscles in group 1 and II diabetic patients comparing to the normal controls. These findings suggest an impaired or immatured neuromuscular junctions and an evidence of reinnervation through axonal sprouting in the diabetic patients either with or without nerve conduction abnormalities. In conclusion, the changes of axonal degeneration and reinnervation are the main pathophysiological mechanism of diabetic neuropathy, and the SFEMG is more sensitive than routine nerve conduction study in the diagnosis of diabetic neuropathyKeyword Axonal degeneration , diabetes mellitus , neuropathy , single fiber electromyography

结果显示两组糖尿病病患的连续间值差异，肌纤维密度及不正常比率比对照组显著增加(t试验，依序p.01)，在第一组糖尿病患中，伸指总肌的连续波间值差异比第二组高(p.05)，而连续波间值差异与纤维密度之间也成线性相关的增加(伸指总肌，r=0.471，p.01；胫前肌，r=0.386，p.02)，在伸指总肌测得的连续波间值差异上，第一组糖尿病患有75%不正常，第二组有33.3%不正常，而在胫前肌的连续波间值差异上，第一组糖尿病患有83.3%的不正常，第二组有75%不正常，在肌纤维密度的测定中，第一组糖尿病患的伸指总肌有27.8%不正常，胫前肌有58.3%不正常，第二组病患的伸指总肌有25%不正常，胫前肌有41.7%不正常，此结果表示糖尿病神经变造成的神经肌像交接处不稳定及有神经轴再生的重分布现象，因此也证实糖尿病神经病变的主要病理机转为神经的退化所致，而在诊断上单纤维肌电图检查的敏感度也比运动神经传导速度检查为高。

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用，保护作用的机制是多方面的，除了改善糖脂代谢，降低血压外，还具有保护小血管内皮，改善凝血和纤溶系统活性，抗炎症等多方面的作用，且作用随着用药时间的延长而日趋明显，在疾病的早期应用效果更佳，故提倡早期用药；对伴有慢性肾功不全的患者，罗格列酮对肾脏靶器官的保护作用显现的并不明显，但副作用与对照组无明显差异，不用根据肾功情况调整用药，但由于样本量较小，上述结论尚需大样本进行进一步证实；本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异，糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性，Prol2Ala与糖尿病及糖尿病肾病不相关。

"The benefits in improved fitness and fatness are clear, and physicians should really have all people with type 2 diabetes actively engaged in an exercise program," says Stewart, who plans to further promote moderate exercise through direct talks with referring physicians and through his monthly health blog to the public while he amasses more evidence about the benefits of exercise in people with the disease.

&的好处改善健康和肥胖是明确的，医师应当真的所有的人与2型糖尿病的积极参与演习计划，&斯图尔特说，谁的计划，进一步促进中等行使通过直接谈判与相关医师，并通过其每月健康博客向公众虽然他amasses更多的证据的好处行使人民的疾病。

The 2006 World Diabetes Day campaign marks the end of the first phase of the J oint IDF-WHO Diabetes Action Now project and coincides with the 19th World Dia betes Congress in South Africa.

2006年糖尿病日活动标志着&现在加入国际糖尿病联盟－世界卫生组织糖尿病活动&计划的第一步完成，同时将在南非举行第19届世界糖尿病会议。

The therapy of protection of liver function is very necessary: diammonium glycyrrhizinate can recover the non-specific damage of liver cells, Fufangdanshen can improve the microcirculation of liver, and tiopronin and reduced glutathione has the unique function to recover liver damage caused by fat invasion. Of 168 cases, 60 cases (35.7%) show exacerbation of liver function after using fat-reducing drugs for 1-2 weeks. Of 41 cases (male 36 and female 5) with the complication DM2, 58.5%(24/41) of cases also show exacerbation of liver function after using sugar-reducing drugs.

保肝治疗非常必要，甘草酸二铵有修复非特异性的肝细胞损伤的作用，复方丹参可以改善肝脏微循环；硫普罗宁或还原性谷胱甘肽，对于脂肪肝之由于脂肪浸润引起的肝细胞损伤的修复有独到的作用。168例中有60例（35.7%）因用降脂药物1～2周出现肝功能异常的加重；合并2型糖尿病的41例（男36例，女5例）患者中有58.5%(24/41)的人用降糖药物后也出现肝功能异常的加重。

Diabetes mellitus is a kind of chronic and worldwide disease, and tight glycemic control is critical in manging DM and preventing complications such as nephropathy, neuropathy and retinopathy. In order to relieve DM patients pain and decrease the risk of crossinfection, noninvasive ways to monitor blood glucose concentrations are preferred, and one approach is to monitor glucose concentrations in tear fluid. This review covers recent understanding of features of tear fluid and relevant changes in DM, the influence of different collecting methods in tear glucose concentration, and attempts to monitor tear glucose concentration in situ by using contactlens based sensing devices.

糖尿病（diabetes mellitus，DM）是一种慢性疾病，也是一种全球性疾病，糖尿病患者长期理想控制血糖有助于防止或延缓糖尿病肾病、神经病变和糖尿病视网膜病变等慢性并发症的发生，为了减少患者的痛苦和降低交叉感染发生的危险，人们想到了通过泪糖浓度这一无创指标来监测血糖控制情况的可能性，我们综合近年的相关研究进展，从泪液的特性及糖尿病患者的相关改变、不同收集方法对泪糖浓度的影响及检测泪糖浓度的产品等方面进一步探讨泪糖浓度作为糖尿病病情评价指标的可行性。

Controlled clinical trials, such as the Diabetes Control and Complications Trial (4) and the Stockholm Diabetes Study in type 1 diabetes (5) and the UK Prospective Diabetes Study(6,7) and Kumamoto study in type 2 diabetes, have helped to establish the glycemic goals of therapy that result in improved long-term outcomes.

在2型糖尿病中临床对照试验，如糖尿病控制和并发症试验（ 4 ）和斯德哥尔摩糖尿病研究1型糖尿病（ 5 ）和英国前瞻性糖尿病研究（ 6，7 ）和熊本研究（ 8 ）说明了建立血糖目标疗法的结果能够改善长期的结果。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。