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糖尿病

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Results The incidence of DM complicated by pulmonary infection was25.4%,which related closely to patient's age,course of disease,the levels of blood glucose and complications(P.05or P.01),however,which didn't relate to sex.The pulmonary infections were ma-inly acute trachitis and bronchitis(42.2%),then pneumonia,chronic bronchitis and pulmonary tuberculosis,etc.

结果 糖尿病伴肺部感染的发生率为25.4%,其发生与年龄、病程、血糖高低及同时存在的糖尿病其他并发症有密切关系(P.05或0.01),而与性别无关;肺部感染类型以急性气管―支气管炎为主(占42.2%),其次为肺炎、慢性支气管炎、肺结核等。

VEGF level is increased continuously in the diabetic kidney of rat. The increased expression of VEGF is mainly located in the glomeruli at the early and middle stages, and is in the tubuli at the middle and late stages. VEGF expression in the diabetic kidney of rat is related to the development of renal changes.

VEGF在糖尿病大鼠肾脏中持续高表达,早中期以肾小球表达上调为主,中后期突出表达在肾小管,其表达变化与糖尿病大鼠肾脏病变发生发展相关。

Male chronic disease is related to hyperlipidemia. Aging is related to higher number of related diseases. Those lived alone with divorce status have a higher percentage of unawared hyperlipidemia. BMI value correlates positively with related diseases and number of diseases. Job holders reported less related diseases. Those who report having hyperlipidemia also register a higher percentage of diabetes. Population in Tauyuan, Shinchu, Miali, Taichung, Chunghua and Nantou counties have higher awareness of self-reporting hyperlipidemia, while population in Kaohsiung, Pingtung and Penhu counties have much lower self-awareness. Furthermore, those having self-reporting hyperlipidemia are statistically significant with their conditions in heart-disease, high-blood pressure, diabetes and kidney disease.

而男性慢性病与高血脂罹患率较高;年龄越大,相关疾病罹患率越高且疾病数越多;离婚分居丧偶自述不知道高血脂疾病状况者较多;BMI值与相关疾病及疾病数成正比;有工作者相关疾病较少;自述有高血脂者,其自述有糖尿病比例最高;桃、竹、苗及中、彰、投地区较清楚自身高血脂疾病状况,而高雄、屏东、澎湖为自述不知道有高血脂机率最高地区;另外自述高血脂疾病状况对心脏病、高血压、糖尿病及肾脏病均达统计显著水准。

In order to further investigate the relationship of SP and ESCs, we design two level experiments —in vitro and in vivo. In vivo, firstly, We establish the nomal rat full-thickness wounds model, and employ integrin β1 keratin 19(K19)、 keratin 15(K15)、 Brdu as ESCs markers to conform the existence of ESCs in the granulation tissue of Group Capsaicin (rats were subcutaneously injected capsaicin pre-injury to damage sensory neuron and block the secretion of neuropeptides), Group Control, and Group SP (rats were injected SP in the wound postinjury). Secondly, as diabetic skin lacking of SP due to extensive pathological changes of sensory ending, we make a hypothesis:one of the main reason of unhealing wounds on diabetic patients could be insufficient SP which lead to fewer ESCs recruitment around wounds.

在此基础上,为进一步验证P物质促进表皮干细胞向肉芽组织中募集这一重要发现,本研究首先利用β1整合素、K19、K15等干细胞标记物以及干细胞慢周期性的特点,分别在体观察了正常皮肤伤口愈合过程中SP组、辣椒素组采用特异性感觉神经毒性药物辣椒素(capsaicin皮下预注射化学性除去感觉神经从而阻止神经肽分泌、对照组肉芽组织中表皮干细胞分布特点;其次,糖尿病患者皮肤存在周围末梢神经的损伤和神经肽含量的下降,这是否会导致糖尿病皮肤伤口创缘表皮干细胞募集不足,继发伤口难愈?

Recipients were ICR and DBA/2J mice without diabetic genetic predisposition and NOD mice not exhibiting oert diabetes during the experiment; offspring were designated as NOD/ICR, NOD/DBA, and NOD/NOD, respectiely; unmanipulated NOD offspring were also examined.

受鼠是没有糖尿病遗传倾向的ICR 和DBA/2J 鼠,以及在实验中没有表现显性糖尿病的NOD鼠。子鼠分别标记为 NOD/ICR, NOD/DBA,和 NOD/NOD。未处理的NOD鼠的子鼠也进入实验。

After three weeks, animals were randomly divided into four groups:(1)diabetic rats received intensive insulin therapy for 20 days;(2)diabetic rats received unregular insulin therapy, which caused the abrupt fluctuation of glycemic level;(3)diabetic control rats; and (4)normal control rats.

中文摘要:目的观察胰岛素治疗对糖尿病大鼠视网膜血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)和血管生成素-2(angiopoietin-2, Ang-2)表达的影响,探讨胰岛素在糖尿病视网膜病变发生发展中的作用。

She is especially good at the management of the eyeground diseases, such as ocular fundus bleeding from various reasons, retinal vascular diseases (such as diabetic retinopathy, retinal vein occlusion, retinal artery occlusion, retinal vasculitis etc.) from diabetes mellitus, hypertension, or various inflammation, retinal capillary hemangioma, vitreous hemorrhage caused by various retinal diseases, optic neuritis, ischemic optic neuropathy, retinal detachment, macular diseases (such as age related macular degeneration, central serous chorioretinopathy, central exudative chorioretinopathy etc.), and other complex diseases such as uveitic diseases and glaucoma etc.

特别是对眼底病如各种原因所致眼底出血;糖尿病、高血压、各种炎症所引起的视网膜血管病如糖尿病视网膜病变、视网膜静脉阻塞、视网膜动脉阻塞、视网膜血管炎症等;视网膜血管瘤病以及其他各种视网膜病所致玻璃体出血;视神经炎、视神经缺血、视网膜脱离、黄斑部疾病如老年性黄斑变性、中浆、中渗等及其他疑难病如葡萄膜炎,青光眼等的诊治积累了大量的临床经验。

Over a six-week period, a small group of people with type 2 diabetes were given 75 to 300 mg of vanadyl sulfate per day.

硫酸氧钒,钒一种形式,可以改善血糖2型糖尿病患者控制。196 197在6型星期内,一小部分人2型糖尿病198人给予75至每天300毫克硫酸钒。

It is a original work in the world that using these ligands to coordinate with vanadyl cation to form complexes and the study of the structures along with the anti-diabetic properties, thus provide us opportunity to obtain vanadium drug with the properties of lowering blood sugar significantly and low toxicity, the research will benefit the large number of diabeticpatients, the economic and social benefit will be obvious.

上述配体与氧钒离子形成配合物及结构和抗糖尿病功能的研究在世界上属首创工作,使我们有望制备出具有显著降血糖功能且低毒性的钒类药物,为广大糖尿病患者带来福音,产生明显的经济效益和社会效益。

Prof. Yangtao: About the prediction of type I diabetes, you said previously in your DAISY study that you can predict the risk for some individual for developing type I diabetes, in some cases exceeding 80%.

杨涛教授:您刚才提到了DAISY预测1型糖尿病研究,有时可以预测80%的糖尿病发生。

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