糖尿病

Purpose To observe the expressions of calpainⅡ in sciatic nerves of diabetic rats, and its implication in the pathogenesis of diabetic polyneuropathy.

目的 观察早期糖尿病大鼠坐骨神经calpainⅡ的动态表达，探讨其在糖尿病多发性神经病发病中的作用。

Objective: To examine changes in gene expression profiling of peripheral blood mononuclear cells in type 2 diabetes patients with distal symmetric polyneuropathy as compared to type 2 diabetes patients without distal symmetric polyneuropathy and to healthy controls.

目的：利用基因芯片技术比较2型糖尿病伴有远端对称性多神经病变的患者、2型糖尿病不伴远端对称性多神经病变的患者以及正常个体外周血单个核细胞基因表达谱的差异。

There has been increasing support for the contribution of immunologic mechanisms in the pathogenesis of diabetic neuropathy, especially in diabetic patients with severe lumbosacral radiculoplexus neuropa-thy, mononeuropathy and distal symmetric polyneuropathy.

越来越多的研究证实，免疫因素参与了糖尿病神经病变，尤其是糖尿病腰骶神经根病、神经病和远端对称性多神经病的发病过程。

Methods: We used a 5075 gene cDNA microarray to examine gene expression in peripheral blood mononuclear cells from two type 2 diabetes patients with distal symmetric polyneuropathy, two type 2 diabetes patients without distal symmetric polyneuro...

采用包含5075个功能已知人类基因的cDNA芯片检测2名2型糖尿病并发远端对称性多神经病变患者，2名2型糖尿病不伴远端对称性多神经病变患者以及2名年龄和性别匹配的正常个体外周血单个核细胞基因表达谱。

"This study found that having periodontal diseases can alter the metabolic conditions which would probably lead to the progression to pre-diabetic characteristics and Type 2 diabetes," said Dr. Carla Pontes Andersen, Department of Periodontology at the University of Copenhagen.

&这项研究发现，有牙周疾病可以改变新陈代谢的条件，可能会导致以循序渐进方式预糖尿病的特征与2型糖尿病，医生说：&卡拉部位安徒生部，牙周病在哥本哈根大学。

Prodromal unstable angina in acute myocardial infarction:prognostic value of short and longterm outcome and predictor of infarct size〔J〕.Am Heart J,2000;140(1):12633.7 Murcia AM,Hennekens CH,Lamas GA,et al.Impact of diabetes on mortality in patients with myocardial infarction and left ventricular dysfunction〔J〕.

而Ghosh等〔9〕的研究认为，IP在糖尿病心脏的保护作用消失机制为，IP通过介导三磷酸腺苷依赖性钾离子通道的激活实现的，而糖尿病能够使体内正常钾离子通道发生改变，从而抑制了IP效应的发挥。

Methods There were to patients of diabetes and 35 patients of non-diabetes in this study. The diameter, inter median thickness, peak systolic velocity, end diastolic velocity, pulsatility index, and resistance index of bilateral common femoral artery, superficial femoral artery, profunda femoral artery, popliteal artery,and pedal artery,and whether there was arteriosclerotic plaque or occlusive diseases were examined with color Doppler ultrasonogh.

糖尿病组70例，非糖尿病组35例，分别应用彩色多普勒超声观察双侧股总动脉、股浅动脉、股深动脉、腘动脉、足背动脉的血管内径、内－中膜的厚度、收缩期最大峰值血流速度、舒张期末血流速度、搏动指数、阻力指数；观察血管内有无硬化斑块、有无完全性和不完全性动脉闭塞。

Objective:To observe and explore the effects of diabetes on thechanges in MDA, GSH-Px content and sexual gland weight in serum,testis,and epididymis using puberal rats with diabetes..

目的：本文以青春期大鼠为研究对象，观察了糖尿病对大鼠血清、睾丸、附睾MDA和GSH-Px的影响，进一步探讨了糖尿病时MDA变化特点和可能机理，及其对睾丸、附睾的影响。

Methods 50 patients with diabetes and contrast group were observed, with transcrianial color Doppler flow imaging, cerebral blood stream velocity; pulsative index,resistive index and S/D were calculated of middle cerebral artery, anterior cerebral artery and posterior cerebral artery Results (1)Changes of cerebral blood stream velocity were non-specifitical in blood waves of TCDFI, but VE was reduced.

目的 为探讨糖尿病对脑血管的，而对脑动脉血流动力学进行对比。经临床诊断糖尿病50例，行TCDFI检测大脑中动脉、大脑前动脉、大脑后动脉等血管的血流速度指标及搏动指数、阻力指数，收缩期血流速度/舒张末期血流速度及频谱形态分析与健康组对照比对分析。结果(1)TCDFI频谱中，血流速度的变化，Vmax是非特异性的，而VE是明显下降的。

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物，包括其药学上可接受的盐和前药，它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物，特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物，这些症状包括肥胖病和脂质疾病，比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。