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糖原

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Glycogen is simply blood glucose stored as a supply of energy , and "glycolytic" refers to the breaking down of glycogen.

糖原只是血糖储存,作为能源供应,以及"糖酵解"指的是打破糖原

Glycogen storage disease type I is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

疾病特征:1型糖原储存疾病(GSD1)的疾病特征是肝脏肾脏糖原和脂肪的积聚,导致肝肿大和肾肿大。

Glucosidase deficiency disease is a rare genetic disorder in which the lysosomal enzyme α-glucosidase is markedly reduced and leads to accumulation of glycogen in various tissues. Its clinical features include massive enlargement of the internal organs, skeletal muscle weakness and hypotonia, and respiratory insufficiency.

阿法-糖苷酶缺乏之全身性糖原质病是一种少见的遗传性疾病,此病主要是因为缺乏阿法-糖苷酶而造成过多的糖原质堆积在各种组识中,导效患者在临床上会有内脏扩大、肌肉无力和呼吸不足等症状。

Carbohydrates were first named according to their natural sources; e.g., beet sugar, cane sugar, grape sugar, malt sugar, milk sugar, cornstarch, liver glycogen, and sweet corn glycogen.

碳水化合物最初是按照它们的天然来源来命名的,例如甜菜糖、甘蔗糖、葡萄糖、麦芽糖、乳糖、玉米淀粉、肝糖原、甜玉米糖原

AIM: This experiment was designed to study the protective effects of maslinic acid, a novel glycogen phosphorylase inhibitor, on cerebral ischemia in mice.

目的:研究糖原磷酸化酶抑制剂-山楂酸对缺血性脑损伤的保护作用,初步探讨糖原磷酸化酶抑制剂的脑缺血保护机制。

Most Americans today have a lifestyle that causes them to live in a constantly anaerobic state, inundated with stress and demands, compounding it with the way they choose to exercise. As a result, they train their metabolism to continuously be anaerobic, i.e. burn glycogen as a primary source of energy. When levels of glycogen become excessively low, the anaerobically trained metabolism turns to blood sugar as its secondly source of fuel.

今天的大多数美国人都有着一种使他们不停地生活在无氧状态下的一种生活方式,他们有着不胜负荷的压力及要求,加上他们所选择的运动方式,他们已经把他们的新陈代谢训化到连续地成为无氧型,比如,以糖原质作为首要的能源消耗,当糖原质变得异常低时,训练成的无氧型新陈代谢系统就开始使用血糖作为第二能耗。

Esults When MSCs were cultured with HGF, FGF-4 and OSM, cuboidal morphology, which was a characteristic of hepatocytes, was observed, and the differentiated cells also expressed marker genes specific to liver cells in a time-dependent manner.α-fetoprotein was expressed on day 10, and CK18, ALB and TAT were detected on day 20, which was in consistent with the immunofluoresence results.

T-PCR和免疫荧光检测结果显示,AFP在诱导初期表达,在诱导后期表达下降;CK18、ALB和TAT的表达与诱导时间呈线性关系,第20天达到表达高峰;诱导20 d后免疫荧光检测,AFP、CK18、ALB和TAT均为阳性;诱导20 d细胞的PAS糖原合成反应呈阳性,即具备糖原合成和储存的肝细胞特有功能。

GSK-3βis now recognized as not only a key rate-limiting enzyme of glycogen metabolic process, which phosphorylats hepatic glycogen synthase and makes it devitalize by insuline regulation, but also plays an important role in at least three signal transductory systems, namely, the Wnt/wingless, PI3'-kinase and Hedgehog pathways,which influence cellular processes, such as protein synthesis, cell proliferation, cell differentiation, cell motility and apoptosis.

GSK-3β是糖原代谢过程中的重要限速酶,除了可以在胰岛素调控下磷酸化肝糖原合成酶并使之失活外,GSK-3β还在多个重要信号通路中扮演了关键角色,例如Wnt/β-catenin pathway,PI3K/AKT pathway,Hedgehog pathway,在蛋白合成、细胞增殖、细胞分化、细胞运动、细胞凋亡以及肿瘤发生等方面都扮演了重要角色。

Following PAS staining, glycogen in hepatoma carcinoma cells mainly expressed near to unilateral cytoplasm surrounding nuclei, showing strong positive expression in the positive control group. Big karyoplasmic ratio and weak expression of glycogen in cytoplasm were visible in the embryonic hepatic progenitor cell group.

PAS染色后阳性对照组肝癌细胞的糖原主要表达在靠近一侧的核周边胞质内,呈强阳性;而胚胎肝前体细胞诱导组,核浆比例大,部分细胞胞质内可见较弱的糖原表达,充满胞质。

The branched nature of glycogen makes it more accessible to glycogen phosphorylase during degradation, since this enzyme degrades the molecule by sequential removal of glucose residues from the nonreducing ends.

糖原的支链性质使它在降解时更易接近到糖原磷酸化酶,因为这种酶降解分子是从非还原端依次去除葡萄糖残基。

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