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糖化

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Constituting dicycle; 2. region selectively reducing six-membered ring ketocarbonyl radical; 3. introducing 7alpha-hydroxy group; 4. Aldol reaction to introduce side chain and obtain 8alpha-hydroxy group; 5. oxidizing the position 7 hydroxy group into ketone; 6. turning the configuration of the position 7 hydroxy group; 7. glycosidating the position 7 hydroxy group; and 8. eliminating protecting group to obtain the target compound.

该方法包括如下步骤:(1)双环的构建;(2)区域选择性还原六元环酮羰基;(3)7α-羟基的引入;(4)Aldol反应引入侧链,同时得到8α-羟基;(5)7位羟基氧化为酮;(6)7位羟基构型的翻转;(7)7位羟基的糖苷化;(8)脱除保护基得到目标化合物。

For instance, ROS is involved in the hypersensitive responses, the lignification of the cell wall, the linkage of proteins and the inducible expression of many genes.

在植物抵御病原微生物的侵染过程中,ROS发挥了重要的作用,如参与超敏反应、细胞壁的木质化、富含经脯氨酸糖蛋白的交联、诱导表达抗病基因及 POD等病程相关蛋白。

The batch-fermentation and fed-batch fermentation of dilute-acid lignocellulose hydrolysates to ethanol using different mixed immobilized cells have been studied.

利用不同菌种的固定化细胞对木质纤维素稀酸水解液进行乙醇发酵,对2#菌进行了以木糖为底物7个批次的驯化培养。

Functional properties of proteins can be improved by mallard reaction.

糖基化反应可以改善蛋白质的某些功能特性。

SIBLINGs, or Small Integrin-Binding Ligand N-linked Glycoproteins, are a family of five proteins that help mineralize bone but can also spread cancer.

SIBLINGs,或称为小整合素结合配体N-连锁糖蛋白,是一种由5个蛋白组成的家族,这些蛋白可帮助骨骼矿化,但也能促使癌症扩散。

The correlation between BMD and age, medical history, menopause duration, BMI, FBG, HbAlc, was analysed student's t test, analysis of variance and coefficient of multiple correlation were used. Results\ BMD decreased in all 80 patients with type 2 DM, of whom 36 (45%) were diagnosed as having OP.

本研究对 80例糖尿病患者骨密度进行了检测,并对其与年龄、病程、体重指数、绝经年限、空腹血糖、糖基化血红蛋白及部分钙磷调节激素的相关性进行了分析,结果报道如下。

The milk-white, instant, harmonious flavor, no off-flavor and palatefull microcapsule of geniposide was developed with geniposide as core material, with βcyclodextrine and malt dextrine as wall material after spray drying under the coditions of 176~180 ℃inlet wind, 106~110℃ outlet wind.

以废液中的栀子甙为芯材、β-环糊精和麦芽糊精为壁材,采用微胶囊化技术,经适当的糖酸调整,进风温度保持176~180℃、出口温度保持106~110℃、于室温下进料,喷雾干燥即可得到乳白、速溶、风味协调、无异味、适口性较好的栀子护肝冲剂。

Rats with CHF were divided randomly into two groups, one group was injected dexamethasone(1mg /kg) intramuscularly at the first and forth day respectively,the other group was injected equi-volume saline likewise, and observing the changes of symptoms of rats with CHF; measuring rats hemodynamics index including blood pressure, heart rate and left ventricular end-diastolic pressure 4 days later. Part 2: To measure every group rats myocardialα1、β1、β2、β3-AR density by immunohistochemical method ,and to understand the AR density changes .Taking the first part rats'myocardium tissues for testing myocardialα1、β1、β2、β3-AR density and 5 normal rats for normo-contrast group and taking gray scale of slice as AR density. Part 3: The study enrolled 35 patients with DCHF. Patients were included if they had orthopnea and refractory edema due to acute DCHF that was severe and had taken more 1 week hospitalization and intravenous therapy in addition to diuretics.

观察心衰大鼠的症状,4天后对两组大鼠进行血流动力学检测,检测指标包括血压、心率和左室舒张末压;第二部分:取第一部分实验动物大鼠的心肌组织,并取5只正常大鼠的心肌组织作为正常对照,用免疫组化法检测大鼠心衰前后及糖皮质激素治疗前后大鼠心肌组织肾上腺素能受体α1、β1、β2、β3受体的变化,取镜下切片的灰度值反应受体的密度;第三部分:研究对象为临床难治性心衰病人35例,病人的选择标准包括由于急性失代偿的心力衰竭出现的端坐呼吸,难治性水肿,患者病情严重,住院超过1周,包括利尿剂之外药物的静脉治疗。

Methods The viral particles of recombinant adeno-associated viral vector 2-IRES-EGFP/MnSOD(rAAV2-IRES-EGFP/MnSOD) were injected into the perilymph through the round window membrane on the 6th week.To observe the feasibility of MnSOD gene therapy for protecting the cochlear function with the methods of Westernblot, ApopTag peroxidase apoptosis detection, MnSOD activity detection and effect on hearing.

方法在半乳糖注射的第6周(注射氨基糖甙类抗生素之前2周)将rAAV2-IRES- EGFP/MnSOD病毒液经圆窗膜注入拟老化大鼠的耳蜗外淋巴,通过免疫组化(ApopTag过氧化物酶凋亡检测)、Westernblot及MnSOD活性检测的方法观察MnSOD基因在对抗内耳氧化应激损伤中的干预性保护作用。

While, the periodate oxidation test showed that the epitopes recognized by Mabs except C1C5 were glycosylated.

高碘酸氧化实验显示,除了C1C5外的其它单抗都是糖基化的。

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