糖代谢

Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的：为了研究金雀异黄素对DN环境下大鼠MC肥大表型转换标志物SMemb和ECM分泌及降解的影响，我们拟在细胞水平以不同浓度的金雀异黄素作用于高糖培养下大鼠MC，在动物水平以同一浓度的金雀异黄素作用于DM大鼠不同时间，观察细胞表型转换标志物SMemb、ECM主要成分Fn、ECM降解酶系统基质金属蛋白酶—2(MMP-2)／基质金属蛋白酶抑制剂—1(TIMP-1)表达的变化，同时观察金雀异黄素对DM大鼠肾脏病理及影响肾脏病进展的糖脂代谢紊乱的影响，并进一步探讨金雀异黄素发挥作用的可能机制；为明确金雀异黄素在DN治疗中的地位及意义提供实验依据。

ConclusionA highiron animal model can be established by intraperitoneal injection of iron dextran. The changes of various parameters result in damage to the organs, it is possible that the ferri ions were released through metabolism of iron dextran and freeion mediates lipid peroxidation to cause the damage.

给小鼠腹腔注射右旋糖酐铁，可以成功建立高铁动物模型，其各项指标有明显变化并对各脏器造成损害，其机制可能与右旋糖酐铁在体内代谢释放出铁离子，游离的铁离子介导脂质过氧化而造成的损害等有关。

ConclusionA highiron animal model can be established by intraperitoneal injection of iron dextran. The changes of various parameters result in damage to the organs, it is possible that the ferri ions were released through metabolism of iron dextran and freeion mediates lipid peroxidation to cause the damage.［KEY WORDS］IronDextran complex; Models, animal; Lipid peroxidation

给小鼠腹腔注射右旋糖酐铁，可以成功建立高铁动物模型，其各项指标有明显变化并对各脏器造成损害，其机制可能与右旋糖酐铁在体内代谢释放出铁离子，游离的铁离子介导脂质过氧化而造成的损害等有关。

Accelerated uptake of glucose and glycolysis was one of the biochemical characteristics of hypoxia cancer cells.

糖的摄取和糖酵解处于增高状态是其生物学特征，葡萄糖转运和代谢对肿瘤细胞至关重要，且导致不良的预后。

18F-FDG is taken up by cells phosphorylated by hexokinase (whose mitochondrial form is greatly elevated in rapidly-growing malignant tumours) and retained by tissues with high metabolic activity such as most types of malignant tumours.

在被细胞摄取之后，18F-FDG将由己糖激酶（在快速生长型恶性肿瘤之中，线粒体型己糖激酶显著升高）加以磷酸化，并为代谢活跃的组织所滞留，如大多数类型的恶性肿瘤。

The induction of xylanase activity is dependent on inducer concentration and is not fully repressible by glucose and starch.

木糖在低浓度下具有诱导WL-11木聚糖酶生物合成的作用，但高浓度木糖则表现出一定的代谢终产物抑制效应。

Key words apple; key enzymes involved in malic acid metabolism; accumulations of malic acid and the soluble sugars

还从苹果酸向可溶性糖转化的角度探讨了苹果酸代谢关键酶对可溶性糖积累的影响。

Objective:To research the influence of Tongluo Tangtai to nerve electrophysiology and sorbitol of rats with diabetic peripheral neuropathy.

目的：研究临床治疗糖尿病性周围神经病变的有效复方通络糖泰对实验性DPN大鼠坐骨神经电生理及糖醇代谢的影响。

Thesynthesized chemical messengers include phospholipid-derived leukotriene B 〓, sphingolipid-derived sphingosine, ceramide, phytosphingosine, and new sphingosine derivativetetrahydroxyl long chain bases.

在核酸和蛋白质继续占据着生命科学中心的同时，脂质及其代谢物、糖及糖缀合物在生命过程中的作用，特别是它们的化学信息物质作用，正被不断揭示，引起了广泛重视。

Sugar is your brain's preferred fuel source -- not table sugar, but glucose, which your body metabolizes from the sugars and carbohydrates you eat.

糖是大脑的最佳能量来源，不过并不是蔗糖，而是葡萄糖，身体通过代谢摄入的糖和碳水化合物产生葡萄糖。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。