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精神治疗

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The purpose of this study was to investigate the relationship between immune variables and psychopathology in patients with chronic schizophrenia before and after neuroleptic treatment, to evaluate the effect of neuroleptic on the immune parameters and the correlation between changes of immune variables and therapeutic effectiveness.

为探讨精神分裂症精神病理与免疫指标的相关性、评估抗精神病药对免疫指标的影响及其与疗效的关系,用固定剂量氟哌啶醇治疗50例慢性精神分裂症患者12周,在治疗前后测查T细胞亚群和白细胞介素2(IL-2)分泌细胞,并采用简明精神病评定量表、阳性症状评定量表和阴性症状评定量表进行评定。

Methods Total of 164 patients with first-episode schizophrenia were evaluated before treatment, at the end of 12 weeks treatment and then annually till 5 years on 10 cognitive function tests, including Weschler adult intelligence scale, Weschler memory scale, grooved pegboard test, finger tapping test, motor function test, hand coordination test, trail making test A and B, Wisconsin card sort test, and verbal fluency test, together with BPRS, SANS and GAF. Results The scores on all cognitive function tests were not significantly related to total scores of BPRS, SANS and GAF before treatment.

对164例首发精神分裂症患者进行随访观察,于治疗前、治疗12周末、治疗1年末、2年末、3年末、4年末、5年末各做1次韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击试验、动作功能测验、手功能协调测验、连线测验A和B、威斯康星卡片分类测验及言语流利性测验等10项神经心理测查及简明精神症状评定量表、阴性症状评定量表、功能总体评定量表评定。

Objective:To compare efficacy and adverse effects of Aripiprazole and Risperidone in the treatment of first episode Schizophrenia Methods:60 cases of Schizophrenia as per CCMD-3 criteria were enrolled and treated. Blood protraction and tasting blood glucose were tested at baseline and 8 weeks after treatment.

目的:以利培酮对照,探讨阿立哌唑治疗首发精神分裂症疗效和不良反应方法:将符合CCMD-3精神分裂症诊断标准的60例患者随机分为阿立哌唑组和利培酮组进行治疗,分别在治疗0、2、4、8周末评定PANSS和TESS量表,在0、4、8周末检查心、脑电图和肝、肾功能。

In spite of the recent remarkable advance in biological psychiatry, including psychopharmacology, improving tremendously the psychiatric care of patients, particularly for those suffering from major psychiatric disorders, there is still a great need to promote psychotherapy for caring of patients suffering from minor psychiatric disorders or emotional problems.

虽然近年来生物精神医学,包括精神药物学,有显著的发展,对精神医疗有明显的改进,特别是对严重性的精神疾病,可是仍然很有需要推展心理治疗,特别是对轻度性的精神疾病或患一般心理问题的病人。

The T; LH and FSH level of serum of male schizophrenia were lower than that of normal control, but the PRL level of serum of male were significant higher than that of normal control, f There wsa a significant relationship between psychiatric symptoms and sex hormones level. There was a positive correlation between extreme and pugnacity factor of PANSS and T level of serum in male schizophrenic patients, There was a negative correlation between psychopathological scores and 〓level of serum in female schizophrenic patients, g There was a significant correlation between neuropsychological tests scores and sex hormones level of serum. There was a significant positive correlation between cognitive function and T level of serum in male schizophrenic patients. There was a significant positive correlation between cognitive function and 〓 in female schizophrenic patients.

治疗后病人的PRL较治疗前有显著提高;6)精神分裂症病人的精神症状与其性激素水平的相关有统计学意义,其中男性病人的T与PANSS中的偏激/好斗呈正相关,女性病人的〓与PANSS中的一般精神病理量表分呈负相关;7)精神分裂症病人的认知功能与其性激素水平的相关有统计学意义,男性病人的神经心理测验成绩与T呈正相关,女性病人的神经心理测验成绩与〓呈正相关。

Sum up: Treatment with electro-acupuncture select Baihui and Shenting points belong to DUmeridian can be of benefit and disbenefit on schizophrene. It is helpful to cognitive function ofschizophrene, increasing memory, attention and perform function, but low efficacy to stability ofAbstract Vattention. It is better that Baihui and Shenting points cooperate with the point on Yin meridians orextremities in treating cognitive impairment of schizophrene with electro-acupuncture.

综上所述,电针百会,神庭穴对精神分裂症患者的治疗有正面和负面的影响,电针可以改善认知功能,提高患者的记忆,注意和执行功能,但对患者的注意的稳定性还缺乏疗效在治疗精神分裂症患者认知功能障碍的过程中,电针百会,神庭穴的同时最好能配合阴经穴位或远端穴位,因研究方法的不同及针对精神分裂症患者的试验难度较大等因素。

Methods:plasmatic neuropeptid y concentration was determined with radioimmunoassay in 38 schizophrenia patients and 20 normal controls.results: compared with normal controls, plasmatic neuropeptid y concentration in schizophrenia patients was significant decreased (t=9.49,p.01).there were significant difference in plasmatic neuropeptid y of patients before and after clozapine treatment (t=2.20,p.05).conclusions: the results suggest that there are abnormal metabolism in plasmatic neuropeptid y of schizophrenia patients .

采用放射免疫法测定38例精神分裂症患者及20例正常对照者的血浆神经肽y含量。结果:精神分裂症患者血浆神经肽y含量较对照组低,差异非常显著(t=9.49,p.01)。精神分裂症患者经氯氮平治疗4周,患者症状好转后,其血浆神经肽 y含量较治疗前显著升高(t=2.20,p.05)。

Objective:To investigate the effectivity and survivability of Olanzapine in the treatment of psychogeny associated with brain disease. Methods:276 patients of psychogeny associated with brain disease were treated with Olanzapine for 12 weeks. All subjects were evaluated with BPRS and TESS. And patients were checked blood and urine routine, liver and renal function, blood sugar, blood fat, CM enzyme, EKG, EEG, chest fluoroscopic examination.

目的:探讨奥氮平治疗脑器质性精神障碍的有效性和耐受性方法:对276例脑器质性精神障碍患者进行12周的奥氮平治疗,使用BPRS、TESS评定治疗效果,治疗后查血常规、尿常规、肝功能、肾功能、血糖、血脂、心肌酶、心电图、脑电图、胸透检查。

Results For single treatment groups,serum drug concentration of chlorpromazine and clozapine were related to age of patients (P<0 05),concentration of clozapine was related to dosage (P=0 01).For combination group,concentration of chlorpromazine was related to dosage (P<0 01),also related to scores of PANSS and general psychopathological symptoms (P=0 01),concentration of clozapine was related to scores of PANSS,negative and general psychopathological symptoms (P<0 05).Multiple linear regression analysis showed that forms and methods of treatment affected concentration of chlorpromazine,age of patients and methods of treatment affected concentration of clozapine.

结果 单用氯丙嗪和采用氯氮平组的血药浓度均与年龄相关(P<0 05),氯氮平血药浓度与剂量线性正相关(P=0 01);在双氯组中的氯丙嗪血药浓度与剂量线性正相关(P<0 01),与PANSS总分及一般精神病理分相关(P=0 01),而氯氮平血药浓度与PANSS总分、阴性量表分及一般精神病理分明显相关(P<0 05);多元回归分析显示,治疗形式和治疗方法影响氯丙嗪血药浓度,年龄和治疗方法影响氯氮平血药浓度。

By realizing the onset、course、pathology、therapy and prognosis of NMO, we draw conclusions as follows after consulting the advances of therapeutic mechanisms and methods on myelitis、optic neuritis、multiple sclerosis、spinal cord injury etc, and combined with the typical case analysis of NMO diagnosed and treated mainly by XNKQ Acupuncture Therapy by stages:1 XNKQ Acupuncture Therapy grasps the soul of Canon of medicine, that is "Be the monarch normal, the followers are safe; while the monarch be abnormal, the twelves followers are dangerous and the channels are obstructed", believes that the main pathological mechanism of NMO be "The vitality can"t direct the qi which making the medulla injuried and the optical passage closed.

通过对NMO发病、病因、病理、治疗、预后的认识,参阅针灸治疗脊髓炎、视神经炎、多发性硬化、脊髓损伤等疾病的治法及作用机制研究进展,结合以醒法为主分期诊治NMO的临床典型病例分析,得出以下结论:1 醒法领会《内经》&主明则下安,主不明则十二官危,使道闭塞不通&的精神,认为本病总病机是&神不导气,髓损目暗&,汲取&凡刺之法,必先本于神&的精髓,确立了&调神导气,益髓明目&总则,分期辨证诊治,具有渊远流长的理论根基和标新立异的创新精神。2 与传统针法相比,醒法治疗NMO具有四大优势,即病机认识的深刻性、选穴处方的独创性、施术操作的规范性和临床疗效的显著性。

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