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A high-performance liquid chromatographic method for the simultaneous separation and determination of aryltetralin lignans and flavonoids in Podophyllum emodi Wall.var. chinesis Sprague was developed. The separation was performed on a Kromasil-C 18 column by gradient elution with phosphate buffer-methanol (0-13min, 50∶50, 33min, 30∶70) as mobile phase at a flow-rate of 0.8 ml/min, with detection 270nm.

首次建立了桃儿七中苦鬼臼葡萄糖甙、4-去甲基鬼臼脂素、表鬼臼脂素、苦鬼臼脂素、苦鬼臼酯酮、鬼臼脂素、鬼臼酯酮、去氧鬼臼脂素、去氢鬼臼脂素等9种木脂素以及山柰酚、槲皮素等2种黄酮类组分同时分离测定的高效液相方法。

The thesis concerning about the total synthesis of some natural occurringlignans and neolignans consists of following five parts:I. Progress in the synthesis of some natural occurring neolignans A view of the synthesis of some natural occurring neolignans, especiallybenzofuraniod and bicyclo[3, 2, 1]octanoid neolignans was given. The syntheticmethods for this two kind of neolignans have been classified and discussed.Ⅱ.

本论文研究了一些木脂素和新木脂素类天然产物的全合成，共包括五部分内容：一、一些新木脂素类天然产物的合成进展对一些新木脂素类天然产物尤其是苯骈呋喃类和双环[3，2，1]辛烷类新木脂素的合成工作进行了较为全面的介绍，并对此类化合物的合成方法进行了分类和讨论。

III. Studies on the total synthesis of macrophllin type of bicyclo[3, 2, 1] octanoid neolignans ( C-4': endo ) The first total synthetic route of macrophllin type of bicyclo[3, 2, 1]octanoidneolignans ( C-4': endo ) was established based on the rearrangement ofbenzofuranoid and bicyclo[3, 2, 1]octanoid neolignans.

三、Macrophllin型双环[3，2，1]辛烷类新木脂素(C-4'桥环为endo)的全合成研究利用氢化苯骈呋喃类新木脂素和双环[3，2，1]辛烷类新木脂素的重排关系，首次建立了macrophllin型双环[3，2，1]辛烷类新木脂素(C-4'桥环为endo)的全合成路线。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

The present doctoral dissertation was carried out to study the chemical constituents isolated from stems of two medicinal schisandraceous plants.34 compounds were isolated from the ethanol extracts of the stems S.henryi collected in the Jiangxi province by various column chromatographies.27 of them were identified on the basis of spectral analysis.There are 18 lignans,(including 5 dibenzocyclooctadienes,6 aryltetralins,2 tetrahydrofurans,3 diarylbutanes,2 other lignans),3 flavanols,2 glyceroesters,1 naphthoquinone,1 xanthine and 2 steroids,of which 6 compounds were new compounds,and 7 compounds were isolated from this family for the first time.

采用多种色谱技术进行分离纯化，从翼梗五味子藤茎的乙醇提取物中分离到34个化合物，综合运用现代波谱学技术鉴定了27个化合物，包括木脂素类化合物18个(其中联苯环辛烯类木脂素5个，芳基四氢萘类木脂素6个，四氢呋喃类木脂素2个，二芳基丁烷类3个，其他类型木脂素2个)，黄烷醇类化合物3个，甘油酯类化合物2个，萘醌类化合物1个，黄嘌呤类化合物1个，甾体类化合物2个，其中，5个为新化合物，7个为本科首次报道。

In terms of paving materials and erecting methods, the steel deck pavement systems adopted in the world can be generalized into four types:The first one is the Gussasphalt. Then is the Mastic Asphalt. Another one is the Stone Mastic Asphalt. And the last one is the Epoxy Asphalt.SMA has been widely applied in western countries such as European countries, Japan and America for its strong anti-track capability and well durability. It is still under experimental stage yet in China.

从铺装材料和施工方法来分类，目前世界上所采用的钢桥面铺装体系，概括起来大致有四类：第一类为高温拌和浇注式沥青混凝土，第二类为沥青玛蹄脂混合料(实际上也是浇注式沥青混凝土，只是拌和、摊铺工艺有所不同)，第三类为沥青玛蹄脂碎石混合料(Stone Mastic Asphalt，简称SMA)，第四类为环氧树脂沥青混合料。

Phytochemical investigation on the acetone extract of the stems of K.oblongifolia led to the isolation of 49 compounds and 31 of them were identified.They were 20 lignans,(including 11 dibenzocyclooctadienes,8 spirobenzofuranoid dibenzocycloocta -dienes,1 other lignan),9 flavones,and 1 nortriterpenoid.Among them,4 were new compounds,1 was new natural products,and 8 compounds were isolated from this family for the first time.

通过对冷饭藤的藤茎化学成分的研究，从丙酮提取物中分离得到49个化合物，鉴定了31个化合物，包括木脂素类化合物20个(联苯环辛烯类木脂素11个，螺苯骈联苯环辛烯类木脂素8个，其他类型木脂素1个)，黄酮类化合物9个，降三萜类化合物1个，其中。4个为新化合物，1个新的天然产物，8个为本科首次报道。

Ecial margarines are prepared in re o e to medical research, which implies a po ible superiority for these types of margarines, e ecially for perso prone to atherosclerotic conditio .

增加多不饱和脂的用量可制成专用的人造奶油。这类专用的人造奶油已经根据医学研究的要求生产出来了。医学研究表明，这种特殊形式的人造奶油可能有好处，尤其对于动脉粥样硬化病倾向的人更有益。

Dr Unger and Dr Scherer suggest that this failure of the leptin mechanism, particularly its role in oxidising lipids, is crucial to the development of metabolic syndrome, and that it is a pathology of adipose tissue that has become overloaded.

昂格尔博士和谢勒博士指出，leptin机制的失效，尤其是在氧化脂类方面的失效对代谢综合症的发展有着关键性的影响，而且这也是过度负载的脂肪组织的一种病状。

Dr Unger and Dr Scherer suggest that thellos failure of the leptin mechanism, particularly its role in oxidising lipids, is crucial to the development of metabolic syndrome, and that it is a pathology of adipose tissue that has become overloaded.

昂格尔博士和谢勒博士指出，leptin机制的掉效，尤其是在氧化脂类方面的掉效对于代谢综合症的成长有着关键性的影响，并且这也是过度负载的脂肪社团的一种病状。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。