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The chemical constituents of Huperzia serrata Trev. are mainly flavonoids, triterpenoids and alkaloids. In order to get further comprehension of lycopodium alkaloids, we studied the low-polar section of the alkaloids extraction of Huperzia serrata and 19 alkaloids were isolated by ways of silica gel, RP-18 and Sephadex LH-20 etc. All of their structures, including five new compounds and two known ones that were firstly found from this genus, were elucidated with the help of Mass, IR, NMR spectra and so on. The five new alkaloids (HS-07, HS-08, HS-09, HS-10 and HS-11) are belonged to lycopodine class. The other two ones that were new to this genus (HS-18 and HS-19) are belonged to miscellaneous group.

蛇足石杉的主要化学成分为黄酮,三萜和生物碱,为进一步了解该植物的生物碱成分,我们研究了蛇足石杉氯仿总碱低极性部位的生物碱成分,运用正相硅胶、反相RP-18、凝胶LH-20等方法分得了19个生物碱,并通过质谱、红外、核磁共振等波谱鉴定了它们的结构,其中5个为新化合物,2个为首次从该属植物中分离得到的化合物,所分得的新化合物:HS-07、HS-08、HS-09、HS-10和HS-11均为lycopodine类石松生物碱,首次从该属植物中分得的化合物为miscellaneous类:HS-18和HS-19。

DFerric Perchloric acid method was used to determine the content of ester-series alkaloid, and acid dye colorimetry was used to determine the content of total alkaloid in Complex Prescription Monkshood plaster.

方法分别采用改良异羟肟酸铁-高氯酸铁法及酸性染料比色法测定制剂中的酯型生物碱及乌头类总生物碱的含量。

MethodsFerric Hydroxamic acid―Ferric Perchloric acid method was used to determine the content of ester-series alkaloid, and acid dye colorimetry was used to determine the content of total alkaloid in Complex Prescription Monkshood plaster.

方法分别采用改良异羟肟酸铁-高氯酸铁法及酸性染料比色法测定制剂中的酯型生物碱及乌头类总生物碱的含量。

The sugar chains are usually trisaccharide or tetrasaccharide, and the aglycones are classified into three groups, i.e., solanidane, spirosolane, and other steroidal derivatives.

糖苷生物碱是主要分布于茄科和百合科植物中的糖苷类次级代谢产物,糖链通常由3或4个单糖组成,苷元通常为三类甾体生物碱:茄次碱烷、螺旋甾碱烷和其他甾体衍生物。

Forty-nine compounds including hydrazines, derivatives of aminoacid and guanidine, and alkaloids of Amaryllidaceae have been examined in vitro and in vivo.

并讨论了非肼类和肼类化合物(包括吲哚类、氨基酸类、胍类、石蒜生物碱、及酰肼类)等49种药物的初筛结果。

Objective: To develop an RP-HPLC method for the determination of synephrine in Pericarpium citri reticulatae viride.

目的:建立青皮药材中生物碱类成分辛弗林的含量测定方法。

Objective To determine simultaneously the contents of ephedrine and pseudoephedrine in ephedra herb and its compound preparations by high performance liquid chromatography.

目的 用反相高效液相色谱梯度洗脱法测定麻黄及其复方制剂中麻黄类生物碱的含量。

The invention relates to a new strain producing taxol and a taxol preparation method. The taxol is a diterpenoid alkaloid drug which is extracted from taxaceae plants and has a plurality of anti-tumor effects. Taxus, also known as yew, is a prehistoric plant with a history of 0.2 billion years and is a rare plant species with low growing speed; the biological characteristics of the taxus have high demand on the ecological environment; the natural renewal ability is poor, so the amount of the species is very limited, belonging to an endangered protection plant with limited resource, thus, scientists at home and abroad actively research and develop new taxol sources. The new strain for producing the taxol of the invention is the strain which is first separated from the bark of T.cuspidate Sieb.

产紫杉醇的新菌种及其选育和制备紫杉醇的方法,紫杉醇是从红豆杉属植物中提取出来的具有多种抗肿瘤疗效的二萜生物碱类药物,由于红豆杉,又名紫杉,是两亿年前的史前植物,是珍稀树种,生长速度缓慢,并且其生物学特性对生态环境要求较高,天然更新能力差,所以种群数量极为有限,属濒危保护植物,资源十分有限,因此,国内外学者都在积极地研究开发紫杉醇的新药源,本发明产紫杉醇的新菌种,所述的新菌种为从东北红豆杉T.cuspidate Sieb。

Background:Matrine is an active ingredient extracted from the traditional Chinese medicine called foxtail-like sophora herb and seed or sophorae radix which contains 98%of oxymatrine.Matrine is a kind of alkaloid which belongs to tetranuclear quinolizidine,and the active component is oxymatrine for it could be deoxidized easily into matrine to produce its effect at the condition of the human intestinal tract where there are bacterium,water,hot and so on.

苦参碱是从中药苦豆子或苦参根中提取的有效成分,含氧化苦参碱约98%,属四环的喹诺里西啶类生物碱,其中苦参碱为活性成分,主要是氧化苦参碱在人体肠道内菌、水、热等成分的共同影响下易被还原为苦参碱而发挥作用。

In the first chapter of the thesis we prepared the desired β-amino aicd ester at first,then throughstereoselective aldol condensation and lactamization we finished the synthesis of Plakoridine A lactam.

本论文中我们从β氨基酸衍生物出发,发展了一些构建多取代吡咯环和吡啶环的方法,并利用这些方法合成了一些具有重要生理活性的生物碱类天然产物。

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