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A series of pyridazino[3,2-c]1,2,4-triazoles were synthesized from hydrazides and 3-aryl-6- chloro pyridazine s (3a～3d), which were obtained from substituted benzene and succinic anhydride by Friedel-Crafts reaction, cyclization with hydrazine hydrate, dehydrogenation and chloro-substitution.

以取代苯和丁二酸酐为起始原料，经Friedel-Crafts反应，肼合环，Br2/HOAc氧化脱氢后得到一系列1，6-二氢-3-芳基-6-哒嗪酮(2a～2d)。然后将2a～2d与PCl5在POCl3中回流，得到相应的氯代产物3a～3d，将其与酰肼作用，合环后得到一系列未见报道的哒嗪并[3，2-c]1，2，4-三唑类化合物。所有化合物结构均经元素分析，IR，1HNMR和MS谱得以证实，并对其波谱性质进行了讨论

These results indiacated that tranferring macrophages combinedwith cytokines could be a new adoptive immunotherapy protocol foradvanced cancer,and rTNF used in vivo locally could induce andactivate macrophages to kill tumor cells.Monocytes when activatedunderwent a series of phenotypic and functional changes includingthe expression of IL-2R which may provide an important immunoregu-latory pathway.The presence of lectin-like molecules on thesurface of monocytes and tumor cells may bring theeffector/target cells together,thus facilitating the inductionof apoptosis in target cells by triggering the production ofcytolytic factors and the modification of target of targer cell surface anti-gens.(such as HLA-DR).

综合以上结果可以得出以下结论：转输巨噬细胞并结合细胞因子的联合应用是肿瘤继承性免疫中的又一新的、有潜力的方法；抗肿瘤细胞因子rTNF可通过激活巨噬细胞在体内抑制对其不敏感的肿瘤细胞的生长；人单核细胞在一定条件下激活后，可表达IL-2R，进而一方面增强其自身对IL-2的敏感性，另一方面在体内也具有调节T细胞功能的作用；单核细胞和肿瘤细胞上存在的凝集素类受体可促使两种细胞之间在凝集素介导下相互接近，并诱发单核细胞产生细胞毒因子，以及通过调节靶细胞上表面抗原的表达，促进诱导靶细胞的细胞凋亡。

Due to the complexity of the cell jitter, the NonSynchronous Tining Recovery methods are currently not mature With the emphasis being given to the Class A CBR traffic, this paper analyzes the performance of the queueing delay and cell jitter at the source node and intermediate nodes, and discusses the Source Timing Recovery at the destination node in ATM networks Firstly, this paper presents a description of the cell jitter of CBR traffic, and gives the definitions of two kinds of cell jitter regarding the Source Timing Recovery for CBR traffic Then, by using exact mathematical models and analysis methods, this paper analyzes the impact of the factors, such as the capacity of the queueing buffer, the randomness, the deterministic nature and the correlation in cell arrivals of the background traffic sources, on the queueing delay and cell jitter performance of the CBR traffic through Statistical Multiplexitng To obtain an insight into the power spectral distribution and look for better schemes for the depression and filtering of the cell jitter, within the analyses we succeed deriving the power spectrum of the cell jitter for CBR traffic Hence, not only the power spectral distribution of the cell jitter can in the frequency domain be qualitatively understood, but also can the rms (root-meansquare) value of the cell jitter be quantitatively obtained so as to more accurately measure the amplitude of the jitter In the end-to-end performance analysis of the queueing delay and cell jitter, we propose a kind of quasi-periodic cell stream model to characterize the jittered CBR traffic, and present an initial queueing analysis of the CBR traffic following such a model at a generic intermediate node Additionally, we briefly discuss the buildout/playout and Source Timing Recovery functions of the destination node Finally, regarding the Source Timing Recovery of CBR traffic, this paper systematically discusses several important principles of the cell jitter filtering and depression reported in the literature, introduces several implementation schemes of the Source Timing Recovery e.

由于信元抖动的复杂性，非同步定时恢复方法目前还很不成熟。本文针对A类CBR业务流在ATM网络源节点和中间节点的排队时延和信元抖动性能，以及在目的节点的源定时恢复问题作了较为全面的研究。首先，文中描述了CBR业务流的信元抖动，并具体地给出了两种与CBR业务源定时恢复有关的信元抖动的定义。然后，采用了精确的数学模型和分析方法，有针对性地分析了业务背景中信元到达的纯随机性、确定性和相关性以及排队缓存器容量等因素对CBR业务流经过统计复用后的排队时延和信元抖动性能的影响。为了了解信元抖动的功率频谱分布和寻求更好的抑制和滤除抖动的方法，在性能分析中，我们成功地完成了CBR业务流信元抖动的功率谱分析，使得不但可以从频域定性地认识信元抖动的能量分布特性，而且还可以定量地求出信元抖动的均方根值(rms：root-mean-square)，以更为准确地衡量抖动的大小。在CBR业务流的多节点端-端排队时延和信元抖动性能分析中，我们提出了一种准周期性(quasi-periodic)信元流模型来描述感染了信元抖动的CBR业务流，并基于这一模型进行了CBR业务流中间节点的初步排队分析。

Considering the difference of the use of clustering algorithms caused by the diffference of data distribution, on the base of the analysis of Kmeans algorithm, fuzzy Cmeans algorithm and genetic algorithm, a new algorithm was brought forward based on the genetic algorithm and the improved neighbor function criterion. In view of the intrinsic connection of the special and the advantage of genetic algorithms wholesearch strategy, to a certian extent, this new algorithm solve the problem about the uncompact and irregular data distribution.

考虑到空间数据分布特性差异造成聚类算法采用的不同，在比较分析K均值算法、模糊均值算法和遗传算法的基础上，提出了改进的近邻函数准则，并有机整合形成遗传算法与改进近邻函数准则的新算法，综合了遗传算法的全局性概率搜索的优点，并考虑到空间数据内在的连接方式，在一定程度上较好地解决了数据的非致密非规则分布问题。

In chapter two we have extended the Mie theory to handle the scattering properties of 4 kinds of dielectric sphere with anisotropy (magnetically gyotropic anisotropy, electrically gyrotropic anisotropy, uniaxially dielectric anisotropy, biaxially dielectric anisotropy), the scattering matrices are obtained.

在第二章，我们推广了Mie散射理论并将其用于研究4类各向异性(旋磁各向异性、旋电各向异性、单轴及双轴各向异性)介质球的散射特性，并最终得出散射矩阵。

The geology research of carbonate reservoirs in Ordovician of Tahe oilfield showed that many large dissolved vugs and fractures were developed. The spread of the reservoir take on a very heterogeneous state. And the typical fractured-vuggy reservoirs was formed. According to the combination of the various spaces, the formation was divided into vuggy formation, fractured-vuggy formation and fractured formation. The research showed that development of the vug is relevant to the its position on the structure, the fractures, the water surface and the weathering surface. Multi-phase charge and recharge of the oil in the reservoirs resulted in the complexity of the fluid distribution. So the"Bottle Model"was brought forward to explain the movement of the water-oil contact. The special storage space and the complex fluid distribution lead to the unstability of the production and the complexity of the water cut. In order to explain the characteristic of the fracture-vug unit was brought forward and the basic principle and method of the partition of the fracture-vug unit was formed. The classification and evaluation of the units were performed according the reserve and energy. Based on the research of geology characteristic and the fluid flow in the reservoir the comprehensive numerical simulation plan of the fractured-vuggy reservoirs were established. Through the selection of the simulation unit, fluid flow type and parameter equivalent the triple media reservoir simulation model was established. Considering the practical application the model was resolved by the DKR decomposition conjugate grads method. Based on the fine reservoir description of Dsitrict IV of the Tahe oilfield the various space type were classified and combined together. The geology model of Unit S48 was constructed. Two typical single well model was established according to the geology and the dynamic phenomena. Finally the single well model and the Unit S48 were simulated by the triple media reservoir simulator. Via the local grid refinement and coarsening in the simulation good matchs were gained. Based on the results of the simulation the reserve distribution, percent of reserve produced in various space and the natural energy were analyzed. The fluid was storaged in the fractures and vugs mostly and more than 90% the produced oil came from the systems. The energy belonged to the active one. The results of simulation accorded with the fact and showed the validity and practicability the research and the simulator.

塔河油田奥陶系碳酸盐岩油藏的地质研究表明，其储层中发育着很多大型的溶蚀洞、缝，储层的平面展布呈现出极度的非均质性，形成了典型的缝洞型碳酸盐岩油藏，根据各种孔隙介质在储层中的组合，将储层分为了溶洞型、裂缝-溶洞型和裂缝型三类；研究表明溶洞储层的发育和构造位置、裂缝的发育、潜水面和风化面的位置等因素有关；多期充注的油气成藏模式导致了流体复杂的赋存状态，由此提出了所谓的&瓶子模型&，解释生产过程中油水界面的变化；特殊的储集空间类型和流体分布特征导致油田在开发过程中表现出很大的不确定性和含水变化的复杂性，为了合理的解释油气田开发过程中的动态特征，提出了&缝洞单元&的概念，并制定了&缝洞单元&纵横向划分的基本原则和依据及划分方法，并对&缝洞单元&进行了分类和评价；基于地质特征和流体在其中流动规律的研究，提出了缝洞型碳酸盐岩油藏的数值模拟综合解决方案，通过模拟单元的选择、流动类型和参数的等效，建立了三重介质油藏三维三相数值模拟模型，采用不完全LU分解预处理共轭梯度法进行了求解；在塔河油田4区精细油藏描述的基础上，将各种类型的孔隙空间进行了归类组合，建立了S48单元的地质模型；通过对油井生产动态进行分析研究，建立了两类和油井地质、生产动态相对应的单井模型；最后应用三重介质油藏数值模拟软件对单井模型和S48单元进行了数值模拟，通过局部加密和粗化等技术模拟流体流动规律，取得了很好的拟合效果；结合数值模拟结果，分析了各种介质中的储量分布、储量产出的百分比以及地层的能量，认为塔河油田缝洞型油藏中流体绝大多数储集于缝洞系统之中，所产出流体90%以上也来自于缝洞系统，其底水能量属于较充足的类型；模拟结果和油田实际情况符合较好，说明了地质研究和油藏数值模拟研究的正确性。

Model GFM-1B dry powder filler is a new product developed by our factory after absorbing the advantages of powder fillers at home and abroad. It can quickly suck dry powder into the cylinder and be directly filled in the cylinder of the extinguisher to be filled by vacuum fluidics; the dry powder can also be directly sucked into the cylinder of the extinguisher to be filled through the filling and cover. It can directly recover the dry powder in the cylinder of the old extinguisher.

GFM16-1B型干粉灌装机是我厂参照国内外粉类灌装机的优点，设计开发的新产品，本机采用真空射流技术，将干粉快速吸入贮粉筒并直接灌入被装灭火器筒体内；也可将干粉通过灌装端盖直接吸入被装灭火器筒体内，并能把旧灭火器筒体内的干粉直接回收。

In addition,the thesis takes into full consideration both different functions and different powers of the factors.It also demarcates the power coefficient by integrating the two and improves the accuracy and differentiating rate of assessment.

其中灰色聚类法和综合模糊评判法均注意到了环境系统的模糊性和不确定性，并通过隶属函数来反映这个属性并加以量化，应用最为广泛，但也存在着一些不足。

Then by cluster analysis on 5 public factors of competitive capacity of 17 cities, classifies all these cities into 7 types and devaluates them respectively.

计算出各城市的竞争力得分，并对6个主成分进行聚类分析，并相应地作出评价。

The crostini may be drizzled with olive oil and salt and served plain, or they may be dressed with an assortment of toppings and used as appetizers or garnishes on foods like soups.

该crostini可drizzled用橄榄油和盐，并平原，或者也可以穿着有各种各样的配料，并用作开胃菜或像汤类食品。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。