类固醇

BACKGROUND: There is a need for more effective therapeutic methods associated with less side effects for the treatment of inner ear diseases such as idiopathic sudden deafness. Intratympanic steroid injection cause local infiltration and lower systemic side effect, however, the efficacy of treatment was not available.

背景：传统上以类固醇治疗突发性耳聋的投予方式不外乎口服、肌肉或静脉注射，但皆有发生全身性副作用的危险性存在；鼓室内注射类固醇只造成局部的吸收，可降低全身性副作用，但其是否有效则尚待研究。

The efficacy of empiric uses of inhaled bronchodilator and corticosteroids may be due to the period effect, withdrawal of such therapy and and re-evaluation may be needed for the confirmation of diagnosis, to avoid the overdiagnosis and overtreatment of bronchial asthma using long-term corticosteroids.

试用性使用吸入型扩张剂或类固醇的效果可能是「时间性效果」。此等病人应在停药后，再作评估以减少误诊及过度长期使用类固醇。

Glucocorticoid induced glaucoma is an open-angle glaucoma which is resulted from periocular or physical glucocorticoid, and Glucocorticoid administration can lead to increased intraocular pressure in greater than 90% of patients with primary open-angle glaucoma.

皮质类固醇激素性青光眼(glucocorticoid induced glaucoma，GIG)是由于眼局部或全身使用皮质类固醇激素(glucocorticoid，GC)而诱发的一种开角型青光眼，文献报道GC可导致90％以上原发开角型青光眼患者眼压升高。

With the pose of aquaporin and the detection of ocular different tissue specificity aquaporin, some researchers believe the expression of AQP1 in trabecular meshwork cells maybe the major factor to GIG, some also suggest that periocular or physical

近年来随着水通道蛋白概念的提出和眼内不同组织特异性水通道蛋白(aquaporin，AQPs)的检出，有学者认为，小梁细胞AQP1的表达可能为皮质类固醇激素引起眼压升高机制的研究带来新的突破，也有学者推测，眼局部或全身使用皮质类固醇激素可能使小梁细胞出现AQP1的异常表达和结构改变，致使房水转导功能下降，眼压升高。

The metabolic and endocrine sequelae of intrafacetal depot steroids have not been studied, but extrapolating from epidural steroid injections, one would expect suppression of the hypothalamic–pituitary–adrenal axis lasting up to 4 weeks depending on the depot steroid used, and impaired insulin sensitivity manifesting as elevated glucose levels for less than a week.251,252 Although rare, a host of infections have been reported after intraarticular injections including septic arthritis, epidural abscess, and meningitis.253–255 Case reports of spinal anesthesia and postdural puncture headache have also been published.256,257

小关节间隙类固醇滞留所产生的代谢和内分泌作用也未见研究，但是从硬膜外类固醇注射可以推知，依据使用量的不同，其抑制下丘脑-垂体-肾上腺轴的时间可以持续4周。很多报道显示关节内注射后可以发生感染，但发生率较少，包括脓毒性关节炎，硬膜外脓肿及脑膜炎。也可见关于脊髓麻痹及穿刺后疼痛的报道。

Since swines were a breed with high reproductivity, we have studied mechanism of acute regulation of piglet testosterone synthesis.

大量的研究表明，类固醇合成快速调节蛋白是调节类固醇合成的限速因子，因此，我们首先研究了StAR蛋白在仔猪睾丸中的表达。

Meanwhile, Jimmytakes steroids to stay competitive and beats the shit out of hisgirlfriend with his crutches in a 'roid rage fit.

同时，Jimmy为了提高竞争力，服用类固醇，结果由于&固醇狂怒&（这是一种服用类固醇后的副作用，人会无法控制自己的情绪，易于暴怒。

The three most common treatments are emollients, topical steroids and oral steroids.

三种最常见的治疗emollients ，局部类固醇和口服类固醇。

To determine the effect of intra-arterial injection of the steroids commonly used for transforaminal epidurals on the central nervous system.

目的：明确常规经椎间孔硬膜外皮质类固醇动脉内注射对中枢神经系统的影响，进一步明确是否所有皮质类固醇均有此作用。

You don't take steroids, do you, because I've heard steroids...

你肯定没有服用类固醇对不对，因为我听说类固醇。。。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。