类化

Meanwhile, several physicochemical descriptors of xanthone molecules were calculated by using quantum chemistry method.

同时，运用量子化学计算了山酮分子的物化参数，并选择相互作用能、疏水常数(log P；其中P为正辛醇-水分配系数)和山酮分子总能量作为分析结构-电泳迁移定量关系的物化参数，用以研究分离机制及在毛细管区带电泳分离中山酮类化合物与β-CD 和磺酸化β-CD间的分子识别过程。

Meanwhile, several physicochemical descriptors of xanthone molecules were calculated by using quantum chemistry method. Among the physicochemical parameters, interaction energy, the logarithms of octanol-water partition coefficient and total energy of xanthone molecules were selected to investigate the separation mechanism and describe molecular recognition process between the xanthones and the CDs in CZE by means of quantitative structure-electromigration relationships.

同时，运用量子化学计算了山酮分子的物化参数，并选择相互作用能、疏水常数(log P；其中P为正辛醇-水分配系数)和山酮分子总能量作为分析结构-电泳迁移定量关系的物化参数，用以研究分离机制及在毛细管区带电泳分离中山酮类化合物与β-CD 和磺酸化β-CD间的分子识别过程。

A series of p-toluene sulfonylamido acetacylhydrazone derivatives were synthesized from p-toluenesulfonyl chloride which reacted with glycine to get the intermediate p-toluene sulfonylamido glycine, then through the esterification, hydrazinolysis to afford another intermediate p-toluene sulfonylamido acethydrazide, which condensed with different aldehydes to obtain the target compounds that were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis.

魏太保 ；冷艳丽；王永成；张建辉；张有明*摘要：以对甲苯磺酰氯为原料，通过与氨基乙酸反应得到中间体对甲苯磺酰氨基乙酸，再经酯化、肼解得到对甲苯磺酰氨基乙酰肼，然后与相应的醛缩合得一系列对甲苯磺酰胺基乙酰腙类化合物。其结构经元素分析， IR， 1H NMR和13C NMR确证。

However, there is no difference for NAT2 rapid and slow acetylator between two groups.

吃红烧鱼因素在NAT2的快速酶中，特别是在野生纯合型中直肠腺瘤复发的相对危险度有增高趋势，提示了NAT2〓4等位基因编码快酶型NAT，可能在红烧鱼产生的杂环胺类化合物中代谢中加速其N-乙酰基化代谢过程，从而加速其代谢为终致癌物而与肠粘膜上皮细胞的DNA产生加成物，损伤其遗传物质。

Nevertheless, Smoking could interact with wild type of NAT2 and increase the relative risk of rectal adenoma recurrence significantly. It is suggested that NAT2 might involve the metabolism of pre-carcinogen generating from tobacco and alter the susceptibility of cancer. Meanwhile, the NAT2〓4 alleles encode rapid acetylator of NAT2 would increase the risk of adenoma recurrence among those high-risk people with habit of fried fish intake.

吃红烧鱼因素在NAT2的快速酶中，特别是在野生纯合型中直肠腺瘤复发的相对危险度有增高趋势，提示了NAT2〓4等位基因编码快酶型NAT，可能在红烧鱼产生的杂环胺类化合物中代谢中加速其N-乙酰基化代谢过程，从而加速其代谢为终致癌物而与肠粘膜上皮细胞的DNA产生加成物，损伤其遗传物质。

AIM: To study the inhibitory effect of IGF binding protein-4 (IGFBP-4), especially in corporation with heparin on the pathopoiesis of insulin-like growth factor-1 (IGF-1) in alveolitis and fibrosis.

目的：探讨类胰岛素生长因子(IGF-1)及其结合蛋白－4(IGFBP-4)、肝素在肺纤维化形成过程中的相互关系。

Emphasis: Aminolysis method of hydroxyl on alcohol, addition amination of epoxy alkyl, aminolysis of aliphatics haloid.

重点：醇羟基的氨解、环氧烷类的加成胺化、脂族卤素衍生物的氨解。

2-Substituted-3,4-dihydro-1(2H)-isoquinolinones were synthesized from methyl 3-hydroxy-ben- zoates via allyl etherification, Claisen rearrangement, oxidation, reductive amination and aminolysis for the first time.

以3-羟基-4-甲氧基苯甲酸甲酯等为原料，通过烯丙基醚化、Claisen重排、氧化、与伯胺反应、还原、分子内酯的胺解六步反应合成了一系列2-取代-3，4-二氢-1-异喹啉酮类化合物。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

SO〓 injury caused a reduction of water, chlorophyll and anthocyanidin, and pH values of the grapes injured by SO〓 were decreased and the intracellular acidification of flesh could be found. SO〓 injury also inhibited activities of SOD, POD and CAT, and deceased ASA contents. Hence the membrane lipid per oxidation was accelerated and the content of MDA and relative electrical conductivity were increased. Treatment of toxic dose of SO〓 increased respiratory rate, lowered activities of PAL and PPO.

与不耐SO〓的品种&红地球&相比，耐SO〓品种&巨峰&具有较高的pH值和较大的缓冲容量，较高的超氧化物歧化酶和苯丙氨酸解氨酶活性；受SO〓刺激后，耐SO〓品种&巨峰&的超氧化物歧化酶及苯丙氨酸解氨酶活性和酚类物质含量上升幅度大于不耐SO〓的品种&红地球&；长期处于SO〓伤害环境时，耐SO〓品种&巨峰&的过氧化氢化酶活性下降幅度低于不耐SO〓的品种&红地球&。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。