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Study on the Crystallization Process of Labeled GL-7-ACA Acylase CA130 Complex 7β-bromoacetyl amino cephalosporanic acid (BA-7-ACA), an analog of glutaryl-7-amino cephalosporanic acid (GL-7-ACA), can inhibit and specifically alkylate GL-7-ACA acylase (CA130) from Pseudomonas sp. 130, forming a carbon-carbon bond between BA-7-ACA and the C-2 on indole ring of Trp-β4 residue of CA130.Here we reported that BA-7-ACA labeled CA130 (BA-C130) could self-catalyze the hydrolysis of BA-7-ACA during crystallization process. The hydrolysis was confirmed to be a reaction analogous to the one of GL-7-ACA by comparative MALDI-TOF (matrix-assisted laser desorption/ionization-time of flight) spectrometry analysis.

二、GL-7-AcA酰化酶CA130标记复合物的结晶过程研究溴乙酰氨基头孢烷酸(7β-bromoacetyl amino cephalosporanic acid,BA-7-ACA)作为戊二酰-7-氨基头孢烷酸(GL-7-ACA)的类似物,不仅能够抑制GL-7-ACA酰化酶CA130的活力,而且能通过在BA-7-ACA和CA130的β亚基第四位色氨酸吲哚环二位碳原子之间形成碳-碳共价键而将CA130特异的烷基化。

An interconnect routing for a card or interposer or the like, including splines of traces on a first layer and traces on a second layer, with vias connecting between the layers.

用于一种卡或插入物或类似物的互连路由,它包括在第一层上的迹线样条(66、69、70)以及在第二层上的迹线(58、60),层之间用通道连接。

Methoxychlor is a DDT substitute and one of endocrine-disrupting chemicals which heavily pollutes the environment.

甲氧滴滴涕是滴滴涕的结构类似物和替代物,是农药内分泌干扰物的一种。

It is similar in structure to αandβ-Asarone that are genetoxic to rat hepatocytes. Carpacin''s isomer, myristicin is not genetoxic to rat hepatocytes and can induce glutathion S-transferase activity that is reported to have effect in rat hepatocytes.

类似物α与β-Asarone对鼠肝细胞具有基因毒性及其异构物myristicin对鼠肝细胞并无基因毒性,且可诱发出glutathion S-transferase等解毒酵素的活性。

This information supports a reasonable probability that all monogastric species eliminate the originally ingested substance, melamine, or its analogues, and not a metabolite.

此信息支持一个合理的概率,所有单胃物种消除原先摄取物质,三聚氰胺,或其类似物,而不是一个代谢物。

Methods: One hundred and twenty patients were divided into two groups at random: control group and observation group. Patients in the control group were only given to nucleoside analog. Patients in the observation group were given to nucleoside analog and the method of strengthening spleen and tonify kidney.

将120例患者随机分为对照组和观察组,每组60例,对照组予核苷类似物治疗,观察组予核苷类似物加健脾补肾方药治疗,疗程均为52周。

DISCUSSION: In obese individuals, somatostatin analog significantly reduced postprandial sensations after a satiating meal without altering maximum tolerated meal volume or postnutrient gastric volume, suggesting an effect on upper gut sensation.

讨论:对于肥胖的个体,生长抑素类似物明显减少饱食后进餐后的感觉,但并没有改变最大进餐耐受容积或营养后的胃容积,提示生长抑素类似物影响上消化道的感觉。

We've taken all the best stuff from similar games, so now you've got a unique game that has no analogues.

我们已经采取了所有最好的东西从类似的比赛,所以现在您有一个独特的游戏,没有类似物

We've taken all the best stuff from similar games, so now you've got a unique game that has no analogues.

我们已经采取了所有最好的东西从类似的游戏,所以,现在你有一个独特的游戏,没有类似物

As a nucleotide analog, synthesization of entecavir not only guides synthesizing other analog, but also is propitious to impolder new nucleotide analog.

做为核苷类似物,恩替卡韦的合成不但可以指导其它该类药物的合成工艺,还有利于开发核苷类似物的新型药物。

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推荐网络例句

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了

The enrich the peopling of Deng Xiaoping of century great person thought, it is the main component in system of theory of Deng Xiaoping economy, it is a when our country economy builds basic task important facet.

世纪伟人邓小平的富民思想,是邓小平经济理论体系中的重要组成部分,是我国经济建设根本任务的一个重要方面。