等周的

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

And straightway comes over the water from some distant cove the same password repeated, where the next in seniority and girth has gulped down to his mark; and when this observance has made the circuit of the shores, then ejaculates the master of ceremonies, with satisfaction,tr-r-r-oonk! and each in his turn repeats the same down to the least distended, leakiest, and flabbiest paunched, that there be no mistake; and then the howl goes round again and again, until the sun disperses the morning mist, and only the patriarch is not under the pond, but vainly bellowing troonk from time to time, and pausing for a reply.

的声音，立刻，从远处的水上，这口令被重复了，这是另一只青蛙，官阶稍低，凸起肚子，喝下了它那一口酒后发出来的，而当酒令沿湖巡行了一周，司酒令的青蛙满意地喊了一声托尔——尔——尔——龙克，每一只都依次传递给最没喝饱的、漏水最多的和肚子最瘪的青蛙，一切都没有错；于是酒杯又一遍遍地传递，直到太阳把朝雾驱散，这时就只有可敬的老青蛙还没有跳到湖底下去，它还不时地徒然喊出托尔龙克来，停歇着等口音。

Parlour games (dominos, halma, tiddledywinks, spilikins, cup and ball, nap, spoil five, bezique, twentyfive, beggar my neighbour, draughts, chess or backgammon): embroidery, darning or knitting for the policeaided clothing society: musical duets, mandoline and guitar, piano and flute, guitar and piano: legal scrivenery or envelope addressing: biweekly visits to variety entertainments: commercial activity as pleasantly commanding and pleasingly obeyed mistress proprietress in a cool dairy shop or warm cigar divan: the clandestine satisfaction of erotic irritation in masculine brothels, state inspected and medically controlled: social visits, at regular infrequent prevented intervals and with regular frequent preventive superintendence, to and from female acquaintances of recognised respectability in the vicinity: courses of evening instruction specially designed to render liberal instruction agreeable.

191室内游戏（多米诺骨牌，希腊跳棋，挑圆片），抽杆游戏，杯球，纳普，抢五墩牌，比齐克，二十五墩，&抢光我的邻居&，跳棋，国际象棋或十五子棋戏）；为警察署资助的服装协会做刺绣、缝补或编织等活计；音乐二重奏：曼陀林和吉他，钢琴和长笛，吉他和钢琴；法律文件的抄写或代填信封上的地址；每隔一周去看一次杂耍演出；从事一些商业活动：一位老板娘在凉爽的牛奶房或暖和的香烟店里愉快地使唤着，愉快地被服从着；在由国家监督、并加以医药管理的男妓院里，暗自从淫欲刺激中得到的满足；与住在附近的一些被公认为品行端正的女友们进行社交活动，需要有不频繁的定期预防性间隔以及频繁的定期预防性监督；为了讲授合适的交往礼仪而专门举办一套夜间讲座。

The second part was to test the appearance, ingredient analysis, surface potential, thermal conduction properties, and magnetism of the nano composite fluid prepared from the parameters. The experiment found that unoxidized particles, Ag, Cu, Fe, and Ni appeared round. If combined with oxygen in water as oxides, the nano particles would grow toward certain directions. In copper/iron nano composite fluid, FeO appeared cubic, Cu2O appeared coniferous. In silver/iron nano composite fluid, FeO was polygonal. In dielectric potential detection, the nano composite fluid was likely to aggregate and deposit, except for silver/iron set. In other sets, the pH of silver/cobalt nano composite fluid was 7, surface potential was 21.21mV; the pH for silver/nickel nano composite fluid was 6.5, surface potential was 21.04mV; the pH for copper/iron nano composite fluid was 7, surface potential was -30mV. The fluid particles of the three sets could all maintain suspension of 2 weeks or more. For thermal conduction, the silver/nickel, nano composite fluid showed the best thermal conduction. Under temperature of 30℃ fluid weight conduction of 0.4%, the thermal conduction increase was 26%. For magnetic detection, except for silver/iron nano composite fluid, the nano particles of other three sets were paramagnetic, and all four sets were soft magnetic nano composite materials.

第二部分。将由较佳制备参数所产出的奈米复合流体，进行形貌外观、成分分析、表面电位及热传导性质实验与磁性检测；在奈米颗粒的形貌部分，经实验发现Ag、Cu、Fe、Ni等未氧化的颗粒皆呈现近似圆形，而若与水中的氧结合形成氧化物，奈米颗粒则会朝特定方向成长，在铜/铁奈米复合流体中FeO为四方体结构、Cu2O的颗粒是针叶状，在银/铁奈米复合流体中FeO则为多边形结构；而介面电位检测方面，结果显示经本制程所产出的奈米复合流体除银/铁奈米复合流体这一组较容易聚集沉淀外，其他三组中银/钴奈米复合流体的pH值为7，表面电位为21.21mV，银/镍奈米复合流体的pH值6.5表面电位为21.04mV而铜/铁奈米复合流体的pH值为7时表面电位约在-30mV，且此三组流体颗粒皆能维持悬浮性2周以上，悬浮性较佳；热传导实验部分，四组奈米复合流体中以银/镍奈米复合流体在增进热传上效果最佳，在温度30℃及流体重量浓度0.4﹪条件下热传导系数增进达26﹪；磁检测方面，除了银/铁奈米复合流体外，其他三组奈米颗粒皆属顺磁性，且这四组奈米复合材料都是属软磁性。

Features of AAD and inflammation were compared between uninfected or unsensitized controls.

结果显示，在感染后的10～15天，我们观察到，衣原体诱导的中等程度的肺部病变，通过增加细菌的数量、肺的组织病理学改变和体重的降低等而得到证实。6周后，感染情况和组织病理的改变得到缓解，体重增加的比率得到恢复。

Great amount of materials about legal history came in sight such as the Codes of the Qin Dynasty excavated in Shuihudi,the Codes of the Han Dynasty in Zhangjiashan,13 Pieces about Observing Laws and Rules etc.in Yinque Mount,the silk book Huang Di Si Jing and Zhou Yi in Mawangdui,and Confucian and Tao literature in Guodian,and other ancient lost books.The reemerging of the codes and literature concerning legal thoughts provides a reliable basis and broad space for rewriting the legal history of China.

出土文献中大量的法律史料，如：睡虎地出土的《秦律》、张家山出土的《汉律》、银雀山出土的《守法守令等十三篇》、马王堆出土的帛书《黄帝四经》与《周易》、郭店出土的儒家与道家文献以及其它古佚书，等等，使久已失传的律典及法律思想方面的文献得以重现，为改写中国法律史提供了可靠的依据和广阔的空间。

A research team at the Johns Hopkins University School of Medicine trained baboons and squirrel monkeys to orally self-administer an Adderall-like drug for two to four weeks, and the team found evidence of amphetamine-induced brain damage, specifically, lower levels of dopamine and fewer dopamine transporters on nerve endings in amphetamine-treated primates than in untreated animals.

一个研究小组在约翰霍普金斯大学医学院的训练狒狒和松鼠猴口头自我管理的Adderall等类药物的2到4周，而且该研究小组发现的证据苯丙胺诱导的脑损伤，特别是较低层次的多巴胺多巴胺转运体和减少对神经末梢的安非他明的待遇比未经处理的灵长类动物。

Results （1） Clinical characteristics included abdominal pain,diarrhea,abdominal distension,nausea,vomiting,low heat and weight,etc.Clinical characteristic symptom relieved with rectification of ketosis and ideally controlling of blood sugar;（2）The counts of acidophil leukocyte in blood and marrow dropped with the relief of symptom ;（3） Endoscopic features concluded mucosal erosion and hydrops,involved the whole stomach,lack of specificity,gastric antrum and ileocecum were more invaded,lots of acidophil leukocytes were seen in biopsy;（4）Hormone,insulin were the first choice to treat eosinophilic gastroenteritis,which could relieve symptom rapidly and reduce acidophil leukocyte to normal;（5）If the diseases recur again and again,the patients should adopt more treatment time,use insulin long time or use immuno-suppressive agent.

结果 （1）患者的临床表现样，包括腹痛、腹泻、腹胀、恶心、呕吐、低热及体重下降等糖尿病酮症的表现；临床症状的缓解随酮症的纠正和血糖控制理想而缓解；（2）外周血和骨髓中嗜酸细胞计随着症状的缓解而下降；（3）内镜下表现多黏膜糜烂和水肿，累及全胃，缺乏特异性，以胃窦和回盲部最常受累，活检可见量嗜酸细胞浸润；（4）激素、胰岛素应用为治疗的线药物，可迅速缓解症状，并使嗜酸细胞恢复正常；（5）病情反复复发的患者可考虑延长激素的治疗时间、长期应用胰岛素或免疫抑制剂。

Results （1） Clinical characteristics included abdominal pain,diarrhea,abdominal distension,nausea,vomiting,low heat and weight,etc.Clinical characteristic symptom relieved with rectification of ketosis and ideally controlling of blood sugar;（2）The counts of acidophil leukocyte in blood and marrow dropped with the relief of symptom ;（3） Endoscopic features concluded mucosal erosion and hydrops,involved the whole stomach,lack of specificity,gastric antrum and ileocecum were more invaded,lots of acidophil leukocytes were seen in biopsy;（4）Hormone,insulin were the first choice to treat eosinophilic gastroenteritis,which could relieve symptom rapidly and reduce acidophil leukocyte to normal;（5）If the diseases recur again and again,the patients should adopt more treatment time,use insulin long time or use immuno-suppressive agent.

结果 （1）患者的临床表现多样，包括腹痛、腹泻、腹胀、恶心、呕吐、低热及体重下降等糖尿病酮症的表现；临床症状的缓解随酮症的纠正和血糖控制理想而缓解；（2）外周血和骨髓中嗜酸细胞计数随着症状的缓解而下降；（3）内镜下表现多为黏膜糜烂和水肿，累及全胃，缺乏特异性，以胃窦和回盲部最常受累，活检可见大量嗜酸细胞浸润；（4）激素、胰岛素应用为治疗的一线药物，可迅速缓解症状，并使嗜酸细胞恢复正常；（5）病情反复复发的患者可考虑延长激素的治疗时间、长期应用胰岛素或免疫抑制剂。

Clinical characteristic symptom relieved with rectification of ketosis and ideally controlling of blood sugar;（2）The counts of acidophil leukocyte in blood and marrow dropped with the relief of symptom ;（3） Endoscopic features concluded mucosal erosion and hydrops,involved the whole stomach,lack of specificity,gastric antrum and ileocecum were more invaded,lots of acidophil leukocytes were seen in biopsy;（4）Hormone,insulin were the first choice to treat eosinophilic gastroenteritis,which could relieve symptom rapidly and reduce acidophil leukocyte to normal;（5）If the diseases recur again and again,the patients should adopt more treatment time,use insulin long time or use immuno-suppressive agent.

结果 （1）患者的临床表现多样，包括腹痛、腹泻、腹胀、恶心、呕吐、低热及体重下降等糖尿病酮症的表现；临床症状的缓解随酮症的纠正和血糖控制理想而缓解；（2）外周血和骨髓中嗜酸细胞计数随着症状的缓解而下降；（3）内镜下表现多为黏膜糜烂和水肿，累及全胃，缺乏特异性，以胃窦和回盲部最常受累，活检可见大量嗜酸细胞浸润；（4）激素、胰岛素应用为治疗的一线药物，可迅速缓解症状，并使嗜酸细胞恢复正常；（5）病情反复复发的患者可考虑延长激素的治疗时间、长期应用胰岛素或免疫抑制剂。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。