等位基因的

The result showed that the I/D polymorphism in intron 16 of the ACE gene was categorized into three genotypes: two dele...

飞行员组II基因型(4 4.0 7%)和I等位基因频率(0 。6 5 )显著高于健康对照组(分别为 31.2 5 %和 0 。5 2 )。结果表明ACEI基因有可能在飞行员的飞行耐力中起重要作用。

MAIN OUTCOME MEASURES: The comparison of the distribution of ACE alleles and genotype in both groups of patients.

主要观察指标：两组患者ACE基因的等位基因和基因型分布比较。

Results There were significant diferences in the distribution of HSP70-1 genotypes and allele frequency between case group and control group.

结果：HSP70-1基因各基因型及等位基因频率在两组中的分布差异有统计学意义。

The result implied that genotype BG of MCW0294 and genotype JL of MCW0258 may be regarded as candidate locus for early assistant selection markers in egg shape index and haugh unit traits of silkies.At the same time, we found some alleles associated with egg quality traits:(1) Means of shell strength for genotype AG and BG of MCW0258 were significantly higher than those of HO and JO.

在多重比较过程中，发现了几个与蛋品质性状显著相关的等位基因：①标记MCWO258中，AG基因型的蛋壳强度均值最高，HO基因型的蛋壳强度均值最低，二者差异显著；BG基因型的蛋壳强度均值较高，JO基因型的蛋壳强度均值较低，二者差异显著。

The power of detecting major gene is related with major gene heritability, allele frequency and sample size.

主基因检测功效的大小和主基因遗传力、等位基因频率、样本大小有关。

ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for hypertension complicated with intracerebral hemorrhage.

ACE基因DD基因型和D等位基因携带者可能是高血压合并脑出血的易感因素。

The present study was designed to elucidate the role of apoE polymorphism in the lithogenesis of cholecystolithiasis and to explore the hereditary pathogenesis of the disease. Polymerase Chain Reaction was used as researching apoE phenotypes and allele frequencies in patients with gallstones (n=87) and in controls (n=50), and the fasting serum lipids of subjects were also measured.

为从分子遗传学水平探讨胆囊结石病的发病机理，采用聚合酶链反应等方法研究了87例胆囊结石患者和50例非结石者的apoE基因表型及等位基因频率，并分析了不同apoE基因表型的胆囊结石患者的血脂质代谢特征。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Methods The method of PCR- RFLP was conducted to examine the genotype of 3 cPLA2 genes ( PLA2G4A, PLA2G4B and PLA2G4C genes) in 263 subjects, including 121 cases of T2DM and 142 controls. The conditional test was used to test the combined effect of distinct loci on the T2DM by conditioning on allele or by conditioning on genotype with UNPHASED analysis platform. Results The genotypic frequencies of the 3 genes did not deviate from Hardy-weinberg equilibrium in both case and control groups.

采用聚合酶链反应-限制性内切酶片段长度多态性方法检测T2DM患者（病例组121例）和健康对照（对照组142例）3个cPLA2基因（PLA2G4A、PLA2G4B和PLA2G4C基因）的基因型；借助UNPHASED分析平台，利用等位基因条件分析和基因型条件分析方法分析基因的联合作用与T2DM的遗传相关性。

The genetic study suggested that the carbendazim-resistance in these mutants could be steadily inherited by asexual and selfed reproduction, and the resistance was controlled by the same single major gene both in laboratory mutants and field resistant isolates, the different levels of resistance or the same resistant level in different strains maybe conferred by mutations at different sites or one site with different allelic mutations. The gene compensates for the sensitivity to MDPC was allelic to that governs the carbendazim resistance, but the mutation for increasing sensitivity to MDPC in this gene could get the pathogen highly resistant to carbendazim.

抗药性遗传研究表明，在所研究的抗药突变体中，抗药性在自交和无性繁殖后代中能稳定遗传；室內抗药突变体和田间抗药菌株对多菌灵的抗药性由同一个主效基因控制，但它们发生突变的位点不同或者同一碱基位点发生了不同的突变；对MDPC的敏感性也是由单个基因控制的，该基因与控制多菌灵抗性的基因是等位基因，当该基因发生对MDPC的敏感性增加的突变时会使病菌对多菌灵产生高水平抗性。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。